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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 3 | Regulation of Wnt/β-catenin signaling by herpesviruses显示文摘The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda. | Kevin J Zwezdaryk Joseph A Combs Cindy A Morris Deborah E Sullivan | 2016 | World Journal of Virology2016，5，4： | 2 |
| 4 | Immunostimulant activity of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris on undernourished mice 显示文摘 | Morris H J Carrillo O Almarales A | 2007 | Enzyme and Microbial Technology2007，40，3： | 1 |
| 5 | The impact of the bulk modulus of diesel fuels on fuel injection timing显示文摘 | Boehman A L Morris D Szybist J | 2004 | Energy & Fuels2004，18，6： | 1 |
| 6 | The growth of Cu-Sn intermetallics at a pretinned copper-solder interface显示文摘 | Sunwoo A J Morris Jr J W Lucey Jr G K | 1992 | Metal Trans1992，23，： | 1 |
| 7 | Statistical performance monitoring of dynamic multivariate process using state space modeling显示文摘 | Simoglou A Martin E B Morris A J | 2002 | Computers and Chemical Engineering2002，26，6： | 1 |
| 8 | Guidelines on smallbowel enterosco- py and capsule endoscopy in adults显示文摘 | Sidhu R Sanders D S Morris A J | 2008 | Gut2008，57，1： | 1 |
| 9 | Structure of extracellular gelling polysaccharide produced by Pseudomonas elodea显示文摘 | O'Neill M A Selvendran R R Morris V J | | 0，，01： | 1 |
| 10 | Adaptivemultivariate statistical process control for monitoringtime-varying processes 显示文摘 | CHOI S W MARTIN E B MORRIS A J | 2006 | Industrial and EngineeringChemistry Research2006，45，9： | 1 |
| 11 | Improved survival with highlyactive antiretroviral therapy in HIV infected patients with severe pneumocystis carinii pneumonia 显示文摘 | Morris A Waehter RM Luce J | 2003 | AIDS2003，17，1： | 1 |
| 12 | 显示文摘 | Zangmeister R A Morris T A Tarlov M J | 2013 | Langmuir2013，29，27： | 1 |
| 13 | Theoretical analysis of strain-induced shape changes cubic precipitates during coarsening显示文摘 | KHACHATURYAN A G SEMENOVSKAYA S V MORRIS J W | 1988 | Acta Metallurgica1988，36，7： | 1 |
| 14 | Process performance monitoring using multivariate statistical process control 显示文摘 | Martin E B Morris A J Zhang J | 1996 | IEE Proceedings: Control Theory and Applications1996，143，2： | 1 |
| 15 | Elevated CO2 drought andsoil nitrogen effects on wheat grain quality显示文摘 | Kimball B A Morris C F Pinter Jr P J | 2001 | New Phytologist2001，150，2： | 1 |
| 16 | 查看详情显示文摘 | Jasionowski M Krzyminski K Chrisler W Markille L M Morris J Gutowska A | | 0，，： | 1 |
| 17 | 查看详情显示文摘 | Humphry K J Kulkarni P M Weitz D A Morris J F Stone H A | | 0，，： | 1 |
| 18 | Immunostim-ulant activity of an enzymatic protein hydrolysatefromgreen microalga Chlorella vulgaris on undernourishedmice显示文摘 | Morris H J Carrillo O Almarales A | 2007 | Enzyme and Microbial Technology2007，40，3： | 1 |
| 19 | Ethylene interacts with acts with abscisic acid to regulate endosperm rupture during germination: a comparative approach using Lepidiumsativur and Arabidopsis thaliana 显示文摘 | Linkies A Muller K Morris K Tureckova V Wenk M Cadman CS Corbineau F Strnad M Lynn J R Finch-Savage W E Leubner-Metzger G | 2009 | Plant Cell2009，21，12： | 1 |
| 20 | Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene显示文摘 | Hasty P Bradley A Morris J H | 1993 | Nature1993，364，： | 1 |
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