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| 1 | 心电图左心室肥厚电压标准与心血管病死亡率的关系显示文摘目前已提出多种使用心电图来诊断左心室肥厚的方法。它们识别病理性肥厚的灵敏度有限,至少部分是由于它们不能区分病理性和生理性肥厚。为此,Ha等使用心血管病死亡作为病理性肥厚的替代指标,比较主要的心电图左心室肥厚标准的预测能力。 | 刘莉 叶鹏 Ha LD Elbadawi A Froelicher VF | 2017 | 中华高血压杂志2017，25，12： | 3 |
| 2 | Salvage gamma knife stereotactic radiosurgery followed by bevacizumab for recurrent glioblastoma multiforme: a case-control study显示文摘We evaluated the efficacy and safety of gamma knife stereotactic radiosurgery(GKSR)followed by bevacizumab combined withchemotherapy in 11 patients with recurrent glioblastoma multiforme who experienced tumor progression despite aggressive | Park KJ Kano H Iyer A Liu X Niranjan A Flickinger JC Lieberman FS Lunsford LD Kondziolka D | 2012 | 中国神经肿瘤杂志2012，10，4： | 3 |
| 3 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 4 | The clinical impact ofnegative psychological states:expanding the spectrum of risk for coronaryartery disease显示文摘 | Davidson KW Rozanski A | 2005 | Psychosom Med2005，67，1： | 1 |
| 5 | Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist 显示文摘 | Prato LD Borini A Cattoli M | 2002 | Fertil Steril2002，77，5： | 1 |
| 6 | Production of interleukin-6,but not interleukin-8,induced by TNF-alpha or IL-1 beta in human fibroblast-like synoviocyte increases over cell passage显示文摘 | Privat SJ Oo A Waterbury LD | 2001 | Proc West Pharmacol Soc2001，44，： | 1 |
| 7 | National surveillance program on susceptibility patterns of respiratory pathogens in South Africa:moxifloxacin compared with eight other antimicrobial agents显示文摘 | Libebowitz LD Slabbert M Huisamen A | 2003 | J Clin Pathol2003，56，5： | 1 |
| 8 | Myocardial in- farction in young adults: angiographie characterization, risk factors and prognosis ( Coronary Artery Surgery Study Registry) 显示文摘 | Zimmerman FH Cameron A Fisher LD | 1995 | J Am Coll Cardiol1995，26，3： | 1 |
| 9 | Combined anteversion technique for total hip arthroplasty显示文摘 | Dorr LD Malik A Dastane M | 2009 | Clin Orthop Relat Res2009，467，1： | 1 |
| 10 | The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner显示文摘 | Wang LD Wang M Todisco A | | 0，，06： | 1 |
| 11 | miR-124 acts through CoREST to control onset of Sema3A sensitivity in navigat-ing retinal growth cones显示文摘 | Baudet ML Zivraj KH Abreu-Goodger C Muldal A Armisen J Blen-kiron C Goldstein LD Miska EA Holt CE | | 0，，： | 1 |
| 12 | Anti-Mullerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization显示文摘 | Fanchin R Mendez LD Frydman N Gougeon A di Clemente N Frydman R Taieb J | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 13 | Inhaled nitric oxide usage in preterm infants in the NICHD neonatal research network:inter-site variation and propensity evaluation显示文摘 | Truog WE Nelin LD Das A | 2014 | Perinatol2014，34，11： | 1 |
| 14 | Sustained activation of JNK/p38MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells显示文摘 | Mansouri A Ridgway LD Korapati AL | 2003 | J Biol Chem2003，278，19： | 1 |
| 15 | Normalization of auditory physiology by cigarette smoking in schizophrenic patients显示文摘 | Adler LE Hoffer LD Wiser A | 1993 | Am J Psychiatry1993，150，： | 1 |
| 16 | Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-induced angiogenesis显示文摘 | Itin A Soffer D | 1992 | Nature1992，359，： | 1 |
| 17 | Cisplatin resistance in an ovarian carcinoma is associated with a defect in programmed cell death control through XIAP regulation显示文摘 | Mansouri A Zhang Q Ridgway LD | 2003 | Oncol Res2003，13，610： | 1 |
| 18 | Quantitation of breast sensibility following reduction mammaplasty: A comparison of inferior and medial pedicle techniques 显示文摘 | Mehrdad MM A LD John JE | 2002 | Plast Reconstr Surg2002，109，7： | 1 |
| 19 | The safety of nickelcontaining dental alloys显示文摘 | Setcos JC Babaei-Mahani A Silvio LD | 2006 | Dent Mater2006，22，12： | 1 |
| 20 | IgA nephropathy : markers of progression and clues to pathogenesis 显示文摘 | Rifai A Dworkin LD | 2008 | Kidney Int2008，73，12： | 1 |
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