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| 1 | microRNA‐directed cleavage of ATHB15 mRNA regulates vascular development in Arabidopsis inflorescence stems显示文摘 | JoonkiKim Jae‐HoonJung Jose L.Reyes Youn‐SungKim Sun‐YoungKim Kyung‐SookChung Jin A.Kim MinsunLee YoontaeLee V.Narry Kim Nam‐HaiChua Chung‐MoPark | 2005 | The Plant Journal2005，，1： | 1 |
| 2 | Three‐vessel view of the fetal upper mediastinum: an easy means of detecting abnormalities of the ventricular outflow tracts and great arteries during obstetric screening显示文摘 | S. ‐J.Yoo Y.‐H.Lee E. S.Kim H. M.Ryu M. Y.Kim H.‐K.Choi K. S.Cho A.Kim | 2002 | Ultrasound Obstet Gynecol2002，，3： | 1 |
| 3 | Gene editing of authentic Brassica rapa flavonol synthase 1 generates dihydroflavonol-accumulating Chinese cabbage显示文摘Flavonols are the major class of flavonoids of green Chinese cabbage(Brassica rapa subsp.pekinensis).The B.rapa genome harbors seven flavonol synthase genes(BrFLSs),but they have not been functionally characterized.Here,transcriptome analysis showed four BrFLSs mainly expressed in Chinese cabbage.Among them,only BrFLS1 showed major FLS activity and additional flavanone 3β-hydroxylase(F3H)activity,while BrFLS2 and BrFLS3.1 exhibited only marginal F3H activities.We generated BrFLS1-knockout(BrFLS1-KO)Chinese cabbages using CRISPR/Cas9-mediated genome editing and obtained transgene-free homozygous plants without off-target mutation in the T1 generation,which were further advanced to the T2 generation showing normal phenotype.UPLC-ESI-QTOF-MS analysis revealed that flavonol glycosides were dramatically decreased in the T2 plants,while dihydroflavonol glycosides accumulated concomitantly to levels corresponding to the reduced levels of flavonols.Quantitative PCR analysis revealed that the early steps of phenylpropanoid and flavonoid biosynthetic pathway were upregulated in the BrFLS1-KO plants.In accordance,total phenolic contents were slightly enhanced in the BrFLS1-KO plants,which suggests a negative role of flavonols in phenylpropanoid and flavonoid biosynthesis in Chinese cabbage.Phenotypic surveys revealed that the BrFLS1-KO Chinese cabbages showed normal head formation and reproductive phenotypes,but subtle morphological changes in their heads were observed.In addition,their seedlings were susceptible to osmotic stress compared to the controls,suggesting that flavonols play a positive role for osmotic stress tolerance in B.rapa seedling.In this study,we showed that CRISPR/Cas9-mediated BrFLS1-KO successfully generated a valuable breeding resource of Chinese cabbage with distinctive metabolic traits and that CRISPR/Cas9 can be efficiently applied in functional Chinese cabbage breeding. | Sangkyu Park Hyo Lee Jaeeun Song Chan Ju Lim Jinpyo Oh Sang Hoon Lee Saet Buyl Lee Jong-Yeol Lee Sunhyung Lim Jin A.Kim Beom-Gi Kim | 2023 | Horticulture Research2023，10，12： | 0 |
| 4 | An efficient synthetic approach towards new 5,5'-diaryl-2,2'-bipyridine-based fluorophores显示文摘An efficient approach has been developed for the synthesis of 5,5'-diaryl-2,2'-bipyridines via their 1,2,4-triazine analogues.The notable advantages of the present method are:The possibility of varying the aromatic substituents in the positions 5 and 5' of bipyridine core and the possibility for obtaining 2,2'-bipyridines bearing a fused cyclopentene core to increase the solubility in organic solvents.These 5,5'-diaryl-2,2'-bipyridines exhibited an intense emission in a range of ca.422-521 nm in acetonitrile solution;depending on the nature of the aromatic substituents and the presence of annulated cyclopentene fragments.Apart from that,the significant bathochromic shifts of the both absorption and emission maxima were observed in comparison with a number of previously described similar structures.In some cases the significant increasing of the fluorescence quantum yields took place. | Alexey P.Krinochkin Dmitry S.Kopchuk Nikolay V.Chepchugov Grigory A.Kim Igor S.Kovalev Matiur Rahman Grigory V.Zyryanov Adinath Majee Vladimir L.Rusinov Oleg N.Chupakhin | 2017 | Chinese Chemical Letters2017，28，5： | 0 |
| 5 | Adult hippocampal neurogenesis and its impairment in Alzheimer's disease显示文摘Adult neurogenesis is the creation of new neurons which integrate into the existing neural circuit of the adult brain.Recent evidence suggests that adult hippocampal neurogenesis(AHN)persists throughout life in mammals,including humans.These newborn neurons have been implicated to have a crucial role in brain functions such as learning and memory.Importantly,studies have also found that hippocampal neurogenesis is impaired in neurodegenerative and neuropsychiatric diseases.Alzheimer’s disease(AD)is one of the most common forms of dementia affecting millions of people.Cognitive dysfunction is a common symptom of AD patients and progressive memory loss has been attributed to the degeneration of the hippocampus.Therefore,there has been growing interest in identifying how hippocampal neurogenesis is affected in AD.However,the link between cognitive decline and changes in hippocampal neurogenesis in AD is poorly understood.In this review,we summarized the recent literature on AHN and its impairments in AD. | Thomas A.Kim Michelle DSyty Kaitlyn Wu Shaoyu Ge | 2022 | Zoological Research2022，43，3： | 0 |
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