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| 1 | Taste masking of ciprofloxacin by ion-exchange resin and sustain release at gastric-intestinal through interpenetrating polymer network显示文摘The aim of the study was to taste mask ciprofloxacin(CP)by using ion-exchange resins(IERs)followed by sustain release of CP by forming interpenetrating polymer network(IPN).IERs based on the copolymerization of acrylic acid with different cross linking agents were synthesised.Drug-resin complexes(DRCs)with three different ratios of drug to IERs(1:1,1:2,1:4)were prepared&evaluated for taste masking by following in vivo and in vitro methods.Human volunteers graded ADC 1:4,acrylic acid-divinyl benzene(ADC-3)resin as tasteless.Characterization studies such as FTIR,SEM,DSC,P-XRD differentiated ADC 1:4,from physical mixture(PM 1:4)and confirmed the formation of complex.In vitro drug release of ADC 1:4 showed complete release of CP within 60 min at simulated gastric fluid(SGF)i.e.pH 1.2.IPN beads were prepared with ADC 1:4 by using sodium alginate(AL)and sodium alginate-chitosan(AL-CS)for sustain release of CP at SGF pH and followed by simulated intestinal fluid(SIF i.e.pH 7.4).FTIR spectra confirmed the formation of IPN beads.The release of CP was sustain at SGF pH(<20%)whereas in SIF media it was more(>75%).The kinetic model of IPN beads showed the release of CP was non-Fickian diffusion type. | A.Michael Rajesh Shreya A.Bhatt Harshad Brahmbhatt Pritpal Singh Anand Kiritkumar Mangaldas Popat | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 2 |
| 2 | Mortality and risk stratification in patients with Clostridium difficile‐associated diarrhoea显示文摘 | S.Bhangu A.Bhangu P.Nightingale A.Michael | 2010 | Colorectal Disease2010，，3： | 1 |
| 3 | Consumer Misperception,Product Failure and Product Liability显示文摘 | Spence A.Michael | | 0，，： | 1 |
| 4 | Consumer Misperceptions,Product Failure and Producer Liability显示文摘 | Spence A.Michael | | 0，，03： | 1 |
| 5 | Clinical outcomes after detection of elevated cardiac enzymes in patients undergoing percutaneous intervention显示文摘 | Barbara E Tardiff Robert M Califf James E Tcheng A.Michael Lincoff Kristina N Sigmon Robert A Harrington Kenneth W Mahaffey E.Magnus Ohman Paul S Teirstein James C Blankenship Michael M Kitt Eric J Topol | 1998 | Journal of the American College of Cardiology1998，，1： | 1 |
| 6 | Clinical correlates and course of thrombocytopenia during percutaneous coronary intervention in the era of abciximab platelet glycoprotein IIb/IIIa blockade显示文摘 | Dean J. Kereiakes Scott D. Berkowitz A.Michael Lincoff James E. Tcheng Kathy Wolski Rob Achenbach Richard Melsheimer Keaven Anderson Robert M. Califf Eric J. Topol | 2000 | American Heart Journal2000，，1： | 1 |
| 7 | The role of spironolactone in the treatment of patients with refractory hypertension显示文摘 | James Ouzan Catherine Pérault A.Michael Lincoff Evelyne Carré Michel Mertes | 2002 | American Journal of Hypertension2002，，4： | 1 |
| 8 | 地震预报——正变得有可能显示文摘地球科学家们已经在加利福尼亚开始预报破坏性地震。虽然地震预报仍不成熟, 但现在做出可信的官方地震警报是可能的。这些警报帮助政府。 | A.Michael P.Reasenberg P.H.Stauffer J.W.HendleyⅡ 杨一飞 | 2002 | 世界地震译丛2002，，5： | 0 |
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