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| 1 | Brain injury and neural stem cells显示文摘Many therapies with potential for treatment of brain injury have been investigated. Few types of cells have spurred as much interest and excitement as stem cells over the past few decades. The multipotentiality and self-renewing characteristics of stem cells confer upon them the capability to regenerate lost tissue in ischemic or degenerative conditions as well as trauma. While stem cells have not yet proven to be clinically effective in many such conditions as was once hoped, they have demonstrated some effects that could be manipulated for clinical benefit. The various types of stem cells have similar characteristics, and largely differ in terms of origin; those that have differentiated to some extent may exhibit limited capability in differentiation potential. Stem cells can aid in decreasing lesion size and improving function following brain injury. | Parker E.Ludwig Finosh G.Thankam Arun A.Patil Andrea J.Chamczuk Devendra K.Agrawal | 2018 | Neural Regeneration Research2018，13，1： | 7 |
| 2 | Spark plasma sintering of a high-energy ball milled Mg-10 wt% Al alloy显示文摘The influence of spark plasma sintering(SPS)temperature on microstructure,hardness and corrosion behavior of a high-energy ball milled Mg-10wt%Al alloy was investigated in this work.The holding time and sintering pressure for SPS were kept constant while varying the sintering temperature from 200 to 350℃.The grain size and microstructure were studied using X-ray diffraction analysis,scanning electron microscopy,energy dispersive X-ray spectroscopy,and Archimedes'based density measurement.Corrosion behavior was investigated using potentiodynamic polarization tests.The nanocrystalline regime(grain size<100nm)was maintained even after SPS up to 350℃.The density of the alloy increased with increasing the SPS temperature.Vickers'hardness and corrosion performance improved up to 300℃ followed by a decrease after SPS at 350℃.Possible reasons for densification,strengthening,and corrosion behavior have been discussed in the light of reduced porosity and microstructural changes. | M.U.F.Khan A.Patil J.Christudasjustus T.Borkar R.K.Gupta | 2020 | Journal of Magnesium and Alloys2020，8，2： | 3 |
| 3 | Efficient and recyclable palladium enriched magnetic nanocatalyst for reduction of toxic environmental pollutants显示文摘In this paper,highly stable,powerful,and recyclable magnetic nanoparticles tethered Nheterocyclic carbene-palladium(Ⅱ)((CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4))as magnetic nanocatalyst was successfully synthesized from a simplistic multistep synthesis under aerobic conditions through easily available low-cost chemicals.Newly synthesized(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst was characterized from various analytical tools and catalytic potential of the(CH_(3))_(3)-NHC-Pd@Fe_3 O_4 magnetic nanocatalyst was studied for the catalytic reduction of toxic 4-nitrophenol(4-NP),hexavalent chromium(Cr(Ⅵ)),Methylene Blue(MB)and Methyl Orange(MO)at room temperature in aqueous media.UV-Visible spectroscopy was employed to monitor the reduction reactions.New(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst exhibited excellent catalytic activity for the reduction of toxic environmental pollutants.Moreover,(CH_(3))_(3)-NHC-Pd@Fe_(3)O_(4) magnetic nanocatalyst could be easily and rapidly separated from the reaction mixture with the help of an external magnet and recycled minimum five times in reduction of 4-NP,MB,MO and four times in Cr(Ⅵ)without significant loss of catalytic potential and remains stable even after reuse. | Manjunatha Kempasiddaiah Vishal Kandathil Ramesh B.Dateer Mahiuddin Baidya Shivaputra A.Patil Siddappa A.Patil | 2021 | Journal of Environmental Sciences2021，33，3： | 1 |
| 4 | Evaluation of Various Factors Affecting Bioconversion of L-Tyrosine to L-DOPA by Yeast Yarrowia lipolytica-NCIM 3450 Using Response Surface Methodology显示文摘3,4-Dihydroxy L-phenylalanine(L-DOPA)is considered a potent drug for the treatment of Parkinson disease.Physical and nutritional parameters where optimized by using Yarrowia lipolytica-NCIM 3450 to accomplished the highest production of L-DOPA.Screenings of critical components were completed by using a Plackett–Burman design,while further optimization was carried out using the Box–Behnken design.The optimized factor levels predicted by the model were pH 6.1,1.659 g L^(-1)yeast extract,1.491 g L^(-1)L-tyrosine and 0.0290 g L^(-1)CuSO4.The predicted yield of L-DOPA with these levels was 1.319 g L^(-1),while actual yield obtained was 1.273 g L^(-1).The statistical analysis revealed that model is significant with F value 19.55 and R2 value 0.9514.This process resulted in a 3.594-fold increase in the yield of LDOPA.L-DOPA was confirmed by HPTLC and HPLC analysis.Thus,Yarrowia lipolytica-NCIM 3450 has potential to be a new source for the production of L-DOPA. | Swati T.Gurme Shripad N.Surwase Sushama A.Patil Jyoti P.Jadhav | 2014 | Natural Products and Bioprospecting2014，4，3： | 0 |
| 5 | Pd/Fe_(3)O_(4) supported on bio-waste derived cellulosic-carbon as a nanocatalyst for C-C coupling and electrocatalytic application显示文摘The current work describes the synthesis of a new bio-waste derived cellulosic-carbon supportedpalladium nanoparticles enriched magnetic nanocatalyst(Pd/Fe_(3)O_(4)@C)using a simple multi-step process under aerobic conditions.Under mild reaction conditions,the Pd/Fe_(3)O_(4)@C magnetic nanocatalyst demonstrated excellent catalytic activity in the Hiyama cross-coupling reaction for a variety of substrates.Also,the Pd/Fe_(3)O_(4)@C magnetic nanocatalyst exhibited excellent catalytic activity up to five recycles without significant catalytic activity loss in the Hiyama cross-coupling reaction.Also,we explored the use of Pd/Fe_(3)O_(4)@C magnetic nanocatalyst as an electrocatalyst for hydrogen evolution reaction.Interestingly,the Pd/Fe_(3)O_(4)@C magnetic nanocatalyst exhibited better electrochemical activity compared to bare carbon and magnetite(Fe_(3)O_(4)nanoparticles)with an overpotential of 293 mV at a current density of 10 mA·cm^(–2). | Vishal Kandathil Akshay Moolakkil Pranav Kulkarni Alaap Kumizhi Veetil Manjunatha Kempasiddaiah Sasidhar Balappa Somappa R.Geetha Balakrishna Siddappa A.Patil | 2022 | Frontiers of Chemical Science and Engineering2022，16，10： | 0 |
| 6 | 气压对空气包覆纱的影响显示文摘空气包覆是一个运用新的组合特点将两种或更多的纱线组合成均匀纱线的过程。这种纱线制织的织物穿着舒适,并可通过改变纱线弹性满足不同的成品要求。空气包覆纱可用以生产不同风格、手感及功能的织物,可根据其性能设计机织物及针织物。研究了气压对聚酯和氨纶空气包覆纱不同性能的影响。分别使用392、588、785 k Pa的气压生产纱线。结果表明:纱线线密度、线圈密度、线圈稳定性及聚酯纱含量随气压的增大而增加。 | T.Patil A.Patil A.Hulle 王日转 颜雪 | 2015 | 国际纺织导报2015，43，6： | 0 |
| 7 | Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera显示文摘Objective:To identify the safe and effective natural inhibitors of spike glycoprotein and main protease 3CLpro using potential natural antiviral compounds which are studied under various animal models and viral cell lines.Methods:First,compounds were retrieved from the Pub Chem database and predicted for their druggability using the Mol Soft web server,and compounds having drug-like property were predicted for major adverse drug reactions like cardiotoxicity,hepatotoxicity,arrhythmia,myocardial infarction,and nephrotoxicity using ADVERpred.Docking of nontoxic antiviral compounds with spike glycoprotein and main protease 3CLpro was performed using Auto Dock vina by PyRx 0.8 version.The stability of compoundprotein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond software.Results:Based on the druggable and nontoxic profile,nine compounds were selected.Among them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of spike glycoprotein(glycosylation site)and main protease 3CLpro via interacting with active site amino acid residues before and after MD simulation at 50 ns.Withanone,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral replication.Conclusion:The current study reports Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a potential lead hit for further experimental validation. | Vishal Shivalingappa Patil Vrushabh B.Hupparage Ajay P.Malgi Sanjay H.Deshpande Sathgowda A.Patil Shamanand P.Mallapur | 2021 | Chinese Herbal Medicines2021，13，3： | 0 |
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