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| 1 | 钴的神经毒性及耳毒性显示文摘钴是参与维生素B12合成和许多生命活动中必不可少的微量元素,然而一旦机体细胞内的钴离子含量因职业暴露或因饮食摄取钴过量或因钴合金人工假体内源性释放超过安全标准,则可导致严重的金属沉着疾病,这种金属沉着病的症状主要包括感音神经性耳聋、神经性耳鸣、视觉缺陷、认知缺陷、心肌病、心衰、甲状腺疾病、皮肤感觉异常等,在上述病症中,感音神经性耳聋和视神经萎缩是最明显的钴中毒症状。钴中毒引起的细胞损害机制主要涉及细胞的氧化应激和缺氧性损害以及线粒体损害引起的细胞凋亡。因此,钴中毒引起的细胞损害模型尤其适用于听觉系统和视觉系统以及神经系统中因细胞内氧化/抗氧化失衡和细胞缺氧以及线粒体凋亡通路等方面的医学实验研究。 | 李鹏 丁大连 曾祥丽 Richard Salvi Jerome A.Roth | 2015 | 中华耳科学杂志2015，13，1： | 13 |
| 2 | Trimethyltin-induced cochlear degeneration in rat显示文摘Trimethyltin(TMT) is an occupational and environmental health hazard behaving as a potent neurotoxin known to affect the central nervous system as well as the peripheral auditory system.However,the mechanisms underlying TMT-induced ototoxicity are poorly understood.To elucidate the effects of TMT on the cochlea,a single injection of 4 or 8 mg/kg TMT was administered intraperitoneally to adult rats.The compound action potential(CAP) threshold was used to assess the functional status of the cochlea and histological techniques were used to assess the condition of the hair cells and auditory nerve fibers.TMT at 4 mg/kg produced a temporary CAP threshold elevation of 25-60 dB that recovered by 28 d post-treatment.Although there was no hair cell loss with the 4 mg/kg dose,there was a noticeable loss of auditory nerve fibers particularly beneath the inner hair cells.TMT at 8 mg/kg produced a large permanent CAP threshold shift that was greatest at the high frequencies.The CAP threshold shift was associated with the loss of outer hair cells and inner hair cells in the basal,high-frequency region of the cochlea,considerable loss of auditory nerve fibers and a significant loss of spiral ganglion neurons in the basal turn.Spiral ganglion neurons showed evidence of soma shrinkage and nuclear condensation and fragmentation,morphological features of apoptotic cell death.TMT-induced damage was greatest in the high-frequency,basal region of the cochlea and the nerve fibers beneath the inner hair cells were the most vulnerable structures. | Jintao Yu Dalian Ding Hong Sun Richard Salvi Jerome A.Roth | 2016 | Journal of Otology2016，11，3： | 3 |
| 3 | SAR polarimetric change detection for flooded vegetation显示文摘Due to spatial and temporal variability an effective monitoring system for water resources must consider the use of remote sensing to provide information.Synthetic Aperture Radar(SAR)is useful due to timely data acquisition and sensitivity to surface water and flooded vegetation.The ability to map flooded vegetation is attributed to the double bounce scattering mechanism,often dominant for this target.Dong Ting Lake in China is an ideal site for evaluating SAR data for this application due to annual flooding caused by mountain snow melt causing extensive changes in flooded vegetation.A curvelet-based approach for change detection in SAR imagery works well as it highlights the change and suppresses the speckle noise.This paper addresses the extension of this change detection technique to polarimetric SAR data for monitoring surface water and flooded vegetation.RADARSAT-2 images of Dong Ting Lake demonstrate this curvelet-based change detection technique applied to wetlands although it is applicable to other land covers and for post disaster impact assessment.These tools are important to Digital Earth for map updating and revision. | B.Brisco A.Schmitt K.Murnaghan S.Kaya A.Roth | 2013 | International Journal of Digital Earth2013，6，2： | 2 |
| 4 | 'Delineation of urban footprints from TerraSAR-X data by analyzing speckle characteristics and intensity information,'显示文摘 | T.Esch M.Thiel A.Schenk A.Roth A.Muller S.Dech | | 0，，02： | 1 |
| 5 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.K(o)nig S.Wiedmann C.Briine A.Roth H.Buhmann L.W.Molenkamp X.-L.Qi and S.-C Zhang | | 0，，5851： | 1 |
| 6 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.K(o)nig S.Wiedmann C.Briine A.Roth H.Buhmann L.W.Molenkamp X.L.Qi and S.C.Zhang | | 0，，5851： | 1 |
| 7 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.KSnig S.Wiedmann C.Briine A.Roth H.Buhmann L.W.Molenkamp X.L.Qi and S.C.Zhang | | 0，，5851： | 1 |
| 8 | 玻纤网碱稳定性的研究显示文摘通过实验对分散剂、薄膜、玻璃纤维网的碱稳定性、失效机理进行分析比较,试图通过混合不同的分散液使稳定性达到最佳。 | M.Hengsberger A.Roth G.Hardtke 郑平 | 2005 | 国际纺织导报2005，33，2： | 1 |
| 9 | Inter‐individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass显示文摘 | A.Roth‐Isigkeit L.Hasselbach E.Ocklitz S.Brückner A.Ros H.Gehring P.Schmucker L.Rink M.Seyfarth | 2001 | Clinical & Experimental Immunology2001，，1： | 1 |
| 10 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.K(o)nig S.Wiedmann C.Brüne A.Roth H.Buhmann L.W.Molenkamp X.L.Qi and S.C.Zhang | | 0，，5851： | 1 |
| 11 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.K(o)nig S.Wiedmann C.Briine A.Roth H.Buhmann L.W.Molenkamp X.L.Qi and S.-C.Zhang | | 0，，5851： | 1 |
| 12 | The New York City High School Match显示文摘 | Abdulkadiroglu A P.Pathak A.Roth | | 0，，02： | 1 |
| 13 | The Boston Public School Match显示文摘 | Abdulkadiroglu A P.Pathak A.Roth T.S?nmez | | 0，，02： | 1 |
| 14 | Quantum Spin Hall Insulator State in HgTe Quantum Wells显示文摘 | M.K(o)nig S.Wiedmann C.Briine A.Roth H.Buhmann L.W.Molenkamp X.L.Qi and S.C.Zhang | | 0，，5851： | 1 |
| 15 | 胰岛素样生长因子——Ⅱ 受体的结构:一个扩大了的“谜”显示文摘胰岛素样生长因子—Ⅱ(IGF-Ⅱ)是和胰岛素及胰岛素样生长因子—Ⅰ(IGF-Ⅰ)有相似结构的一种多肽激素。与其他激素所不同的是,IGF-11在活体内的功能是未知的。IGF-Ⅱ虽可在分离的细胞内对广泛的生物反应有促进作用,但发现它的这些作用通常是受胰岛素和IGF-Ⅰ受体所调解。最近发现IGF-Ⅰ[ | Richard A.Roth 范宗理 | 1989 | 世界科学1989，11，4： | 0 |
| 16 | 肠病毒疫苗的设计及应用策略(二)显示文摘许多生物制品公司致力于开发安全有效的PEDv疫苗来替代返饲诱导免疫。然而,返饲和疫苗两者间没解决的问题是后备母猪和经常母猪间不同的乳源性免疫诱发水平。改策略对配种前的后备猪未必有效,因为肠-乳腺淋巴细胞的转运与妊娠激素有关。 | 张坤 kuldeep s.chattha james a.roth linda j.saif | 2016 | 今日养猪业2016，0，12： | 0 |
| 17 | 新型高速气动染色工艺显示文摘描述了由Then机械公司和Clariant公司合作开发的新型高速气动染色工艺———High-Speed Leveling(HSL)。HSL体现了现代染色机,技术成熟产品和计算机辅助及最优化工艺控制之间的相互关系。除了大量节约时间,色牢度高以外,匀染性和织物外观均非常好。 | R.Adrion A.Roth 张艳 | 2005 | 国际纺织导报2005，33，11： | 0 |
| 18 | Leaching of lanthanide and yttrium from a Central Appalachian coal and the ashes obtained at 550-950℃显示文摘In this work,we investigated leaching of lanthanide and yttrium(REY) from a Central Appalachian coal and its ashes obtained at 550-950℃ with the main purpose of understanding the impact of ashing temperature on REY leachability in water,ammonium sulfate,and hydrochloric acid.It is found that the coal contains a negligible amount of water-soluble REY,less than 1% ion-exchangeable REY,and about 28% of HCl-soluble REY.Ashing leads to dramatic changes in REY leachability in both ammonium sulfate and hydrochloric acid solutions,which is believed to be related to transformation and redistribution of organically-associated REY in coal during the ashing process.Ashing temperature significantly affects REY leaching from coal ashes;higher ashing temperature results in lower REY leachability in both solutions.Clay minerals may play a significant role in changing the leachability of REY after ashing.In addition,the results also suggest that the organic matter in the coal is relatively enriched in heavy REY. | Ronghong Lin Yee Soong Bret H.Howard Murphy J.Keller Elliot A.Roth Ping Wang Evan J.Granite | 2022 | Journal of Rare Earths2022，40，5： | 0 |
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