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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | The ef- fect of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs 显示文摘 | DUGAN M E R AAI HUS J L SCttAEFER A L | 1997 | Can J Anim Sci1997，77，： | 1 |
| 3 | In vivo induction of necrosis in mice fibrosareoma via intravenous injection of type B staphylococcal enterotoxin 显示文摘 | Fooladi AAI Sattari M Hassan ZM | 2008 | Biotechnol Lett2008，30，12： | 1 |
| 4 | Optimal linear cooperation for spectrum sensing in cognitive radio networks 显示文摘 | Quan Zhi Cui Shuguang and Aayed A H | 2008 | IEEE Journal of Selected Topics in Signal Processing2008，2，1： | 1 |
| 5 | Recurrent lacrimal gland plBeomorphic adenoma: clinical and computed tomography features 显示文摘 | McNab AAI Satchi K | 2011 | Ophthalmology2011，18，10： | 1 |
| 6 | Outbreak of pneumocystis pneumonia in renal and liver transplant patients caused by genotypically distinct strains of Pneumocystis jirovecii显示文摘 | Rostved AAI Sassi M Kurtzhals JA | 2013 | Transplantation2013，96，9： | 1 |
| 7 | Cooling ofwateflowing through a night sky radiator显示文摘 | Hamza A Aai H Taha IM S | 1995 | Solar Energy1995，55，4： | 1 |
| 8 | Breast Cancer Subtypes Based on ER/PR and Her2 Expression: Comparison of Clinicopathologic Features and Survival 显示文摘 | Onitilo AAI Engel JM Greenlee RT | 2009 | Clin Med Res2009，7，12： | 1 |
| 9 | Dermoscopy for the family physician显示文摘 | Marghoob AAI Usatine RP Jaimes N | 2013 | Am Fam Physician2013，88，87： | 1 |
| 10 | Catalytic synthesis of (R) and (S) citronellol by homogeneous hydrogenation over amidophosphine phosphinite and diaminodiphosphine rhodium complexes 显示文摘 | Allaoud S Karim A | 1995 | Tetrahedron: Asymmetry1995，6，： | 1 |
| 11 | Is This Patient Having a Myocardial Infarction 显示文摘 | | 1998 | JAMA1998，280，4： | 1 |
| 12 | Laparoscopic-assisted repair of Morgagni hernia in children显示文摘 | Mohammad Saquib Mallick Aayed Alqahtani | 2009 | Journal of Pediatric Surgery2009，44，： | 1 |
| 13 | Molecularchar-acterizationofShigatoxin-producingisolatedfromtheenvironmentofadairyfarm 显示文摘 | PolifroniR EtcheverríaAI SanzM E etal | 2012 | Curr Microbiol2012，65，3： | 1 |
| 14 | Dictionary-Based Cross-Langiage Information Retrieval: Problems, Methods, and Research Findings显示文摘 | Aai Pirkola Turid Hedlund&Heikki Keskustalo | 2001 | Information Retrieval2001，，4： | 1 |
| 15 | Cooling of water flowing through a night sky radiator 显示文摘 | Hamza A Aai H Taha I M S | 1995 | Solar Energy1995，55，4： | 1 |
| 16 | Dispersion of filler and the electrical conductivity of polymor blends filled with carbon black显示文摘 | Sumita M Sakata K Aai S | 1991 | Polymer Bulletin1991，25，2： | 1 |
| 17 | IFN-γ at the site of infection determines rate of clearance of infection in cryptococcal meningitis显示文摘 | Siddiqui AAI Brouwer AE Wuthiekanun V | 2005 | J Immuno12005，174，3： | 1 |
| 18 | Reductive leaching of ilmenite ore in hydrochloric acid for preparation of synthetic ru-tile显示文摘 | Mahmoud MHH Afifi AAI Ibrahim I A | 2004 | Hydrometallurgy2004，73，1： | 1 |
| 19 | Inhibitory effect of curcuminiods on MCF-7 cell proliferation and structure-activity rclatiohship显示文摘 | Simon A Aais DP Duroux JL | 1998 | Cancer Lctt1998，129，： | 1 |
| 20 | Adipose-derivedaduh stromal cells heal critical-size mouse calvarial defects 显示文摘 | COWAN C M SHI Y Y AAI AMI O O | 2004 | Nat Biotechnol2004，22，5： | 1 |
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