|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Interferon-γ inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism显示文摘AIM:To investigate if and how the proinflammatory cytokine interferon γ(IFNγ) affects ghrelin expression in mice.METHODS:The plasma concentration of ghrelin,andgastric ghrelin and somatostatin expression,were examined in wild-type mice and mice infected with Helicobacter pylori(H.pylori).Furthermore,ghrelin expression was examined in two achlorhydric mouse models with varying degrees of gastritis due to bacterial overgrowth.To study the effect of IFNγ alone,mice were given a subcutaneous infusion of IFNγ for 7 d.Finally,the influence of IFNγ and somatostatin on the ghrelin promoter was characterized.RESULTS:H.pylori infection was associated with a 50% reduction in ghrelin expression and plasma concentration.Suppression of ghrelin expression was inversely correlated with gastric inflammation in achlorhdyric mouse models.Subcutaneous infusion of IFNγ suppressed fundic ghrelin mRNA expression and plasma ghrelin concentrations.Finally,we showed that the ghrelin promoter operates under the control of somatostatin but not under that of IFNγ.CONCLUSION:Gastric infection and inflammation is associated with increased IFNγ expression and reduced ghrelin expression.IFNγ does not directly control ghrelin expression but inhibits it indirectly via somatostatin. | Jesper AB Strickertsson Kristina BV DΦssing Anna JM Aabakke Hans-Olof Nilsson Thomas VO Hansen Ulrich Knigge Andreas Kjr Torkel Wadstrm Lennart Friis-Hansen | 2011 | World Journal of Gastroenterology2011，17，26： | 2 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Retrospective evaluation of the clinical and ra-diographic risk factors associated with severe pulmonary hemorrhage in first-line advanced,unresectable non-small cell lung cancer treated with Carboplatin and Paclitaxel plus bevacizumab显示文摘 | Sandler AB Schiller JH Gray R Dimery I Brahmer J Samant M Wang LI Johnson DH | 2009 | J Clin Onco2009，27，9： | 1 |
| 4 | Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy显示文摘 | García-Escudero R Martínez-Cruz AB Santos M etc | 2010 | Mol Cancer2010，9，： | 1 |
| 5 | A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties显示文摘 | Olsen D B Eldrup AB Bartholomew L Bhat B Bosserman M R Ceccacci A Colwell L F Fay J F Flores O A Getty K L Grobler J A LaFemina R L Markel E J Migliaccio G Prhavc M Stahlhut M W Tomassini J E MacCoss M Hazuda D J Carroll S S | | 0，，10： | 1 |
| 6 | Causes of creslal bone resorption in the dental implant patient显示文摘 | Al-Juboori M J Ab R S | 2012 | Dental lmplantology Update2012，11，1： | 1 |
| 7 | Geographic localization of knowledge spillovers as evidenced by patent citations 显示文摘 | Jaffe AB Trajtengerg M Henderson R | 1993 | Quarterly Journal of Economics1993，108，3： | 1 |
| 8 | Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells显示文摘 | Kodali R Hajjou M Berman AB | | 0，，03： | 1 |
| 9 | Improvement of thermal stability via outer-loop ion pair interaction of mutated T1 lipase from Geobacillus zalihae strain T1 显示文摘 | Ruslan R Rahman RNZRA Leow TC Ali MSM Basri M Salleh AB | 2012 | Intern J Mol Sci2012，13，： | 1 |
| 10 | Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithe- lial iNOS显示文摘 | Roos AB Mori M Gronneberg R | 2014 | PLoS One2014，9，90： | 1 |
| 11 | Papillary carcinoma of the thyroid with fibromatosislike stroma: case report and review of literature 显示文摘 | Khalil AB Trudel M Creel R | 2010 | Endocr Pract2010，16，4： | 1 |
| 12 | Chemokines induce matrix metalloproteinase-2 through activation of epidermal growth factor receptor in arterial smooth muscle cells 显示文摘 | Kodali R Hajjou M Berman AB | 2006 | Cardiovasc Res2006，69，3： | 1 |
| 13 | Case report:MRI appearance of isolated fallopian tube torsion in an adolescent with a congenital Mullerian duct anomaly and ispilateral renal agenesis显示文摘 | Kopec M Rosenkrantz AB Rivera R | | 0，，01： | 1 |
| 14 | Comparative analyses of multi-species sequences from targeted genomic regions显示文摘 | Thomas JW Touchman JW Blakesley RW Bouffard GG Beckstrom-Sternberg SM Margulies EH Blanchette M Siepel AC Thomas PJ McDowell JC Maskeri B Hansen NF Schwartz MS Weber RJ Kent WJ Karolchik D Bruen TC Bevan R Cutler DJ Schwartz S Elnitski L Idol JR Prasad AB | | 0，，6950： | 1 |
| 15 | Elevated exhaled nitric oxide in allergen-provoked asthma is associated with airway epithelial i NOS显示文摘 | Roos AB Mori M Grnneberg R | 2014 | PLo S One2014，9，90： | 1 |
| 16 | Hyponatremie encephalopathy mimicking hypoxic-ischemie encephalopathy 显示文摘 | Nardone R McCoy M Kunz AB | 2010 | Clin Neuroradiol2010，20，4： | 1 |
| 17 | Sphincterotomy-associated biliary strictures:features and endoscopic management 显示文摘 | Bourke M J Elfant AB Alhalel R | 2000 | Gastroint est Endosc2000，52，4： | 1 |
| 18 | The adolescent varicocele II:the incidence of hydrocele and delayed recurrent varicocele after varicocelectomy in a long-term follow-up显示文摘 | Misseri R Gershbein AB Horowitz M | 2001 | BJU Int2001，87，6： | 1 |
| 19 | Nitric oxide releasing nanoma-terials for cancer treatment: current status and perspectives显示文摘 | Seabra AB De Lima R Calder6n M | 2015 | Curr Top Med Chem2015，15，4： | 1 |
| 20 | Immunochemistry and?lung cancer: application in diagnosis, prognosis and targeted therapy显示文摘 | NANGUZGAMBO AB RAZACK R LOUW M | 2011 | Oncology2011，80，34： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员