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| 1 | Relationship between HER-2 overexpression and brain metastasis in esophageal cancer patients显示文摘AIM:To study if HER-2 overexpression by locally advanced esophageal cancers increase the chance of brain metastasis following esophagectomy.METHODS:We retrospectively reviewed the medical records of esophageal cancer patients who underwent esophagectomy at University of Iowa Hospitals and Clinics between 2000 and 2010.Data analyzed consisted of demographic and clinical variables.The brain metastasis tissue was assayed for HER-2 overexpression utilizing the FDA approved DAKO Hercept Test.RESULTS:One hundred and forty two patients were reviewed.Median age was 64 years(36-86 years).Eighty eight patients(62%) received neoadjuvant chemoradiotherapy.Pathological complete and partial responses were achieved in 17(19%) and 71(81%) patients.Cancer relapsed in 43/142(30%) patients.The brain was the first site of relapse in 9/43 patients(21%,95% CI:10%-36%).HER-2 immunohistochemistry testing of the brain metastasis tissue showed that 5/9(56%) cases overexpressed HER-2(3+ staining).CONCLUSION:HER-2 overexpression might be associated with increased risk of brain metastasis in esophageal cancer patients following esophagectomy.Further studies will be required to validate this observation. | Taher Abu Hejleh Barry R DeYoung Eric Engelman Jeremy M Deutsch Bridget Zimmerman Thorvardur R Halfdanarson Daniel J Berg Kalpaj R Parekh William R Lynch Mark D Iannettoni Sudershan Bhatia Gerald Clamon | 2012 | World Journal of Gastrointestinal Oncology2012，4，5： | 5 |
| 2 | Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients显示文摘AIM: To investigate the protein expression profi le of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations. METHODS: Immunohistochemical analysis of tumor samples was performed to determine the protein expression profile of MMR protein. Germline mutation screening was carried out on peripheral blood samples. The entire exon regions of MLH1 and MSH2 geneswere amplifi ed by polymerase chain reaction, screened by denaturing high performance liquid chromatography (dHPLC) and analyzed by DNA sequencing to characterize the germline mutations. RESULTS: Three out of 34 tissue samples (8.8%) and four out of 34 tissue samples (11.8%) showed loss of nuclear staining by immunohistochemistry, indicating the absence of MLH1 and MSH2 protein expression in carcinoma cells, respectively. dHPLC analysis followed by DNA sequencing showed these samples to have germline mutations of MSH2 gene. However, no deleterious mutations were identifi ed in any of the 19 exons or coding regions of MLH1 gene, but we were able to identify MLH1 promoter polymorphism, -93G > A (rs1800734), in 21 out of 34 patients (61.8%). We identified one novel mutation, transversion mutation c.2005G > C, which resulted in a missense mutation (Gly669Arg), a transversion mutation in exon 1, c.142G > T, which resulted in a nonsense mutation (Glu48Stop) and splice-site mutation, c.2006-6T > C, which was adjacent to exon 13 of MSH2 gene. CONCLUSION: Germline mutations were identified in four Malaysian Lynch syndrome patients. Immunohistochemical analysis of tumor tissue proved to be a good pre-screening test before proceeding to germline mutation analysis of DNA MMR genes. | Mohd Nizam Zahary Ravindran Ankathi Human Genome Centre Gurjeet Kaur Muhammad Radzi Abu Hassan Harjinder Singh Venkatesh R Naik | 2012 | World Journal of Gastroenterology2012，18，8： | 3 |
| 3 | Prevalence of pu- tative virulence factors and antimicrobial susceptibility of En- terococcus faecalis isolates from patients with dental diseas- es 显示文摘 | Salah R Dar-Odeh N Abu Hammad O | 2008 | BMC Oral Health2008，8，： | 1 |
| 4 | Phase equilibria and thermodynamics of the Mg-Sn-Ca system (Part 2): Experimental investigation of ternary Mg-Sn-Ca phase equilibria and solidification microstructure 显示文摘 | KOZLOV A OHNO M ABU LEIL T HORT N KAINER K U SCHMID-FETZER R | 2008 | Intermetallics2008，16，： | 1 |
| 5 | Effect of surfactants on sorption of atrazine by soil显示文摘 | ABU ZREIG M RUDRA R P DICKINSON W T | 1999 | Journal of Contaminant Hydrology1999，36，34： | 1 |
| 6 | Treatment of severe intradialytic hypotension with the addition of high dialysate calcium concentration to Midodrine and/or cool dialysis显示文摘 | Alappan R Cruz Abu Alfa AK | 2001 | Am J Kidney Dis2001，37，2： | 1 |
| 7 | A physicallybased gradient plasticity theory显示文摘 | ABU AL-RUB R K VOYIADJIS G Z | 2006 | International Journalof Plasticity2006，22，3： | 1 |
| 8 | Structure of a major im- munogenic site on foot and mouth disease virus 显示文摘 | Logan D Abu G R Blakemore W | 1993 | Nature1993，362，6420： | 1 |
| 9 | Management of cervical carcinoma di-agnosed during pregnancy 显示文摘 | Eitan R Abu - Rustum NR | 2003 | Prim Care Update Ob/Gyns2003，10，4： | 1 |
| 10 | Effects of insulin deprivation and treatment on homocysteine metabolism in patients with type I diabetes 显示文摘 | Abu - Lebdeh H S Barazzoni R Meek S E | 2006 | J Clin Endocrinol Metab2006，91，9： | 1 |
| 11 | Treatment of servere intradialytic hypotension with the addition of high dialysate calcium concentration to midodrine and cool dialysate显示文摘 | Alappan R Cruz DN Abu -Alfa Ak | 2001 | Am J kidney Dis2001，37，2： | 1 |
| 12 | The effects of food processing on biogenic amines formation显示文摘 | Chong C Y Abu Bakar F Russly A R | 2011 | Interna- tional Food Research Journal2011，18，3： | 1 |
| 13 | Biodegradation of hydrocarbons in soil by microbial consortium显示文摘 | FARINAZLEEN M G RAJA N Z A R ABU B S | 2004 | International Biodeterioration & Biodegradation2004，54，： | 1 |
| 14 | Biotechnical use of the polymerase chain reaction for microbial analysis of biological samples显示文摘 | LANTZ P G ABU AL-SOUD W KNUTSSON R | 2000 | Biotechnology Annual Review2000，5，： | 1 |
| 15 | Mucosal benign epithelioid nerve sheath tumors显示文摘 | Lewin M R Dilworth H P Abu Alfa A K | 2005 | Am J Surg Pathol2005，29，10： | 1 |
| 16 | Influence of temperature and pH on biomass production and protein biosynthesis in a putative Spirulina sp 显示文摘 | Ogbonda K H Aminigo R E Abu G O | 2007 | Bioresour Technol2007，98，： | 1 |
| 17 | A Micro-damage Healing Model That Improves Prediction of Fatigue Life in Asphalt Mixes显示文摘 | ABU AL-RUB R K DARABI M K LITTLE D N | 2010 | In- ternational Journal of Engineering Science2010，48，11： | 1 |
| 18 | Comparing Finite Element and Constitutive Modeling Techniques for Predicting Rutting of As- phalt Pavements 显示文摘 | ABU AL-RUB R K DARABI M K HUANG C W | 2012 | International Journal of Pave- ment Engineering2012，13，4： | 1 |
| 19 | Biogenie amine changes in barramundi (Lates calcarifer) slices stored at 0 C and 4 C 显示文摘 | Bakar J Yassoralipour A Abu Bakar F Rahman R A | 2010 | Food Chemistry2010，119，2： | 1 |
| 20 | A Thermo viscoelastic-viscoplastic-viscodamage Constitutive Model for Asphaltic Materials显示文摘 | DARABI M K ABU AL-RUB R K MASAD E A | 2011 | Inter- national Journal of Solids and Structures2011，48，1： | 1 |
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