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| 1 | Serum MiRNA as Predictive and Prognosis Biomarker in Advanced Stage Non-small Cell Lung Cancer in Indonesia显示文摘Background and objective Lung cancer is the most common cause of death in men in the world and in Indonesia where nonsmall cell carcinoma lung cancer(NSCLC) constitutes 85% of all lung cancer cases. The high mortality rate is due to a poor prognosis and is often diagnosed as having advanced stages. If it is known at the initial stage, the prognosis of lung cancer will be better. Prognosis can be predicted with a marker of prognostic biology, one of which is micro RNA(mi RNA). This study aims to prove that serum mi RNA can be predictive biological marker and prognosis in NSCLC patients in Indonesia.Methods This study was cohort retrospective among 52 subjects in 'Dharmais' Hospital National Cancer Center. Sample was obtained from patients’ serum. Mi R-34, mi R-148, mi R-155 and mi R-222 serum are measured through Real-Time PCR(q PCR). Data were analyzed and interpreted with descriptive analysis, bivariate analysis(Mann Whitney-U for two type of variables or Kruskal-Wallis for more than two type of variables. Kaplan-Meier analysis was used to know association between characteristic which are sociodemographic, performance status, clinico-pathology, and survival rate in mi RNA expression. Results From this study, mi RNA expression: mi R-34(46.15%), mi R-148(23.08%), mi R-155(40.38%) and mi R-222(32.69%). Performance status score was statistically significant correlation with mi R-148(P=0.049) and mi R-222(P=0.018). High mi R-34 is associated with multiple M1 b metastatic type(P=0.020), cancer cell type(adenocarcinoma, P=0.009) and adenocarcinoma epidermal growth factor receptor(EGFR) mutation(negative, P=0.031). There was a significant correlation between the high mi R-222 as a poor prognosis in advanced stage NSCLC with M1 b metastasis(Median Survival/MS: 27 d, P=0.049) and positive EGFR mutations(MS: 74 d, P=0.049) and correlation of mi R-155 with adenocarcinoma(MS: 69 d, P=0.034) and positive EGFR gene mutations(MS: 58 d, P=0.023).Conclusion High mi R-34 expression in advanced stage NSCLC is the predictive factor for multiple metastatic, adenocarcinoma cell type and adenocarcinoma negative EGFR mutation. High expression of mi R-155 and mi R-222 are poor prognoses, especially high mi R-222 found in metastasis M1 b and positive EGFR mutation and mi R-155 found in adenocarcinoma and positive EGFR gene mutations. Further studies regarding correlation between mi RNA and survival rate are needed. | Arif R HANAFI Achmad M JAYUSMAN Serafim ALFASUNU Ahmad H SADEWA Dibyo PRAMONO Didik S HERIYANTO Sofia M HARYANA | 2020 | 中国肺癌杂志2020，23，5： | 6 |
| 2 | Structural studies of three sesquiterpenes from Litsea spp (Lauraceae) 显示文摘 | Hakim E H Achmad S A Effend E L | 1993 | AustJChem1993，46，9： | 1 |
| 3 | Overview on the application of direct methanol fuel cell(DMFC) for portable electronic devices 显示文摘 | Kamarudin S K Achmad F Daud W R W | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 4 | Ovelwiew on the application of direct methanol fuel cell (DMFC) for portable electronic devices显示文摘 | KAMARUDIN S K ACHMAD F DAUD W R W | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 5 | Overview on the application of direct methanol fuel cell (DMFC) for portable electronic devices 显示文摘 | Kamarudin S K Achmad F Daud W R W | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 6 | Artoindonesi- anin L,a new prenylated flavone with cytotoxic activ- ity from Artocarpus rotund显示文摘 | Suhartati S A Achmad N Aimi | 2001 | Fitoterapia2001，72，8： | 1 |
| 7 | Overview on the application of direct methanol fuel cell (DMFC) for portable elec- tronic devices显示文摘 | KAMARUDIN S K ACHMAD F DAUD W R W | 2009 | International Journal of Hydrogen Energy2009，34，16： | 1 |
| 8 | Overview on the application of direct methanol fuel cell (DMFC) for portable electronic devices显示文摘 | Kamamdin S K Achmad F Daud W R W | 2009 | International Joumal of Hydrogen Energy2009，34，16： | 1 |
| 9 | Artoindonesianin L: A new prenylated flavone with cytotoxic activity from Artocarpus rotunda 显示文摘 | Suhartati T Achmad S A Aimi N | 2001 | Fitoterapia2001，72，8： | 1 |
| 10 | Stability of lutein and its myristate esters显示文摘 | ACHMAD S HIROKO W NAOFUMIM | | 0，，10： | 1 |
| 11 | Optimising feedback using the Mini-CEX during the final semester programme显示文摘 | Dewi S Achmad TH | 2010 | Meal Educ2010，44，1： | 1 |
| 12 | Application of nonlinear feature extraction and support vector machines for fault diagnosis of induction motors显示文摘 | ACHMAD W YANG B S | 2007 | Expert Systems with Applications2007，33，1： | 1 |
| 13 | Combination of independent component analysis and support vector machines for intelligent faults diagnosis of induction motors显示文摘 | ACHMAD W YANG B S TIAN H | 2007 | Expert Systems with Applications2007，32，： | 1 |
| 14 | Application of nonlinear feature extraction and support vector machines for fault diagnosis of induction motors显示文摘 | ACHMAD W YANG B S | 2007 | Expert Systems with Applications2007，33，： | 1 |
| 15 | Application of relevance vector machine and logistic regression for machine degradation assessment显示文摘 | WAHYU C ACHMAD W Y B S | 2010 | Mechanical Systems and Signal Processing2010，，： | 1 |
| 16 | Fault diagnosis of low speed bearing based on relevance vector machine and support vector machine 显示文摘 | ACHMAD W ERIC Y J-D S | 2009 | Expert Systems with Applications2009，，： | 1 |
| 17 | Application of nonlin- ear feature extraction and support vector machines foe fault diagnosis of induction motors 显示文摘 | W Achmad B S Yang | 2007 | Expert System with Applications2007，33，01： | 1 |
| 18 | Fault diagnosis of low speed bearing based on relevance vector machine and support vector machine显示文摘 | ACHMAD W ERIC Y K JONG-DUK S | 2008 | Expert Systems with Applications2008，36，3： | 1 |
| 19 | Overview onthe application of direct methanol fuel cell (DMFC)forportable electronic devices显示文摘 | Kamarudin S K Achmad F Daud W R W | 2009 | Int J Hydrog Energy2009，34，69： | 1 |
| 20 | Influence of stiff-stemmed grass hedge systems on infiltration显示文摘 | Achmad Rachman Anderson S H Gantzer C J | 2004 | Soil Science Society of America Journal2004，68，6： | 1 |
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