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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | The environmental fate of phthalate esters: a literature review显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 5 | Measurements of acute cerebral infarction: a clinical examination scale 显示文摘 | Brott T Adams H P Jr Olinger C P | 1989 | Stroke1989，20，7： | 1 |
| 6 | Nucleotide sequence, polymorphism, and evolution of ovine MHC class Ⅱ DQA genes 显示文摘 | Scott P C Gogolin-Ewens K J Adams T E | 1991 | Immunogenetics1991，34，2： | 1 |
| 7 | The environmental fate of phthalate esters: a literature review 显示文摘 | Stales C A Peterson D R Parkerton T F Adams W J | 1997 | Chemosphere1997，35，4： | 1 |
| 8 | Ca Cu3Ti4O12:One-step internal barrier layer capacitor显示文摘 | Sinclair D C Adams T B Morrison F D | 2002 | Applied Physics Letters2002，80，12： | 1 |
| 9 | Comparison of several sulfluramid bait formulations for control of the red imported fire ant (Hymenoptera:Fotmicidae)显示文摘 | Banks W A Las A S Adams C T | 1992 | Journal of Entomological Science1992，27，： | 1 |
| 10 | R1 region of P97 mediates adherence of Mycoplasma hyopneumoniae to swine cilia 显示文摘 | Minion FC Adams C Hsu T | 2002 | Infect Immun2002，68，5： | 1 |
| 11 | Transposon derived Brucella abortus rough mutants are attenuated and exhibit reduced intracellular survival显示文摘 | Allen C A Adams L G Ficht T A | 1998 | Infect Immun1998，66，： | 1 |
| 12 | A close to universal negative ion source显示文摘 | Middleton R Adams C T | 1974 | Nuclear Instruments and Methods1974，118，2： | 1 |
| 13 | Use of preoperative three-dimensional computed tomography to quantify glenoid bone loss in shoulder instability显示文摘 | Chuang T Y Adams C R Burkhart S S | | 0，，04： | 1 |
| 14 | Boron in holocene illites of the Dovey estuary, wales, and its rel-ationship to palaeosa- Hnity in cyclothems显示文摘 | Adams T D Haynes J R Walker C T | 2006 | Sedimentology2006，4，3： | 1 |
| 15 | The effects of Fenton's reagent pretreatment on the biodegradability of nonionic surfactants 显示文摘 | Kitis M Adams C D Daigger G T | 1999 | Water Research1999，33，11： | 1 |
| 16 | A fiber-opticDNA biosensor microarrary for the analysis of gene expression显示文摘 | Boles T C Adams C P | 1996 | Nat Biochnol1996，14，13： | 1 |
| 17 | Host immune response deter- mines visceral hypeialgesia in a rat model of post-inflammatory irrt- able bowel syndrome 显示文摘 | Adam B Tsopelas C Liebregts T | 2013 | J Gastroenterol2013，11，6： | 1 |
| 18 | Relations between the photoluminescence efficiency of CdTe nanocrystals and their surface properties revealed by synchrotron XPS显示文摘 | BORCHERT H TALAPIN D V GAPONIK N MCGINLEY C ADAM S LOBO A MOLLER T WELLER H | 2003 | J Phys Chem B2003，107，36： | 1 |
| 19 | Bayesian estimation of follower and leader vehicle poses with a virtual trailer link model显示文摘 | Ng T C Adams M Ibanez-Guzman J | 2008 | International Journal of Robotics Research2008，27，1： | 1 |
| 20 | Aggressive be-havior is reduced in bulls actively immunized against gonadotropin releasing hormone显示文摘 | PRICE E O ADAMS T E HUXSOLL C C | 2003 | Anita Sci2003，81，2： | 1 |
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