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| 1 | Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis显示文摘The pool of microbes inhabiting our body is known as 'microbiota' and their collective genomes as 'microbiome'. The colon is the most densely populated organ in the human body, although other parts, such as the skin, vaginal mucosa, or respiratory tract, also harbour specific microbiota. This microbial community regulates some important metabolic and physiological functions of the host, and drives the maturation of the immune system in early life, contributing to its homeostasis during life. Alterations of the intestinal microbiota can occur by changes in composition(dysbiosis), function, or microbiota-host interactions and they can be directly correlated with several diseases. The only disease in which a clear causal role of a dysbiotic microbiota has been demonstrated is the case of Clostridium difficile infections. Nonetheless, alterations in composition and function of the microbiota have been associated with several gastrointestinal diseases(inflammatory bowel disease, colorectal cancer, or irritable bowel syndrome), as well as extra-intestinal pathologies, such as those affecting the liver, or the respiratory tract(e.g., allergy, bronchial asthma, and cystic fibrosis), among others. Species of Bifidobacterium genus are the normal inhabitants of a healthy human gut and alterations in number and composition of their populations is one of the most frequent features present in these diseases. The use of probiotics, including bifidobacteria strains, in preventive medicine to maintain a healthy intestinal function is well documented. Probiotics are also proposed as therapeutic agents for gastrointestinal disorders and other pathologies. The World Gastroenterology Organization recently published potential clinical applications for several probiotic formulations, in which species of lactobacilli are predominant. This review is focused on probiotic preparations containing Bifidobacterium strains, alone or in combination with other bacteria, which have been tested in human clinical studies. In spite of extensive literature on and research into this topic, the degree of scientific evidence of the effectiveness of probiotics is still insufficient in most cases. More effort need to be made to design and conduct accurate human studies demonstrating the efficacy of probiotics in the prevention, alleviation, or treatment of different pathologies. | Rafael Tojo Adolfo Suárez Marta G Clemente Clara G de los Reyes-Gavilán Abelardo Margolles Miguel Gueimonde Patricia Ruas-Madiedo | 2014 | World Journal of Gastroenterology2014，20，41： | 33 |
| 2 | Challenging the interoperability between computers in industry with MDA and SOA 显示文摘 | RICARDO J G ANTONIO G ADOLFO S G | 2006 | Computers in Industry2006，57，8： | 1 |
| 3 | Multifractal analysis of soil spatial variability 显示文摘 | Adolfo N D P Daniel G Marco B | 1999 | Agronomy Journal1999，91，6： | 1 |
| 4 | The virus battkes: IFN induction of the antiviral state and mechanisms of viral evasion 显示文摘 | Elevy D Adolfo G S | 2001 | Cytokine and Growth Factor Reviews2001，，12： | 1 |
| 5 | Innate immune evasion strategies of influenza viruses显示文摘 | Hale Benjamin G Albrecht Randy A GarcííA-Sastre Adolfo | 2010 | Future Microbiology2010，，1： | 1 |
| 6 | Operational oceanography system applied to the prestige oil-spillage event显示文摘 | MANUEL G LUIS F ADOLFO U | 2008 | Journal of Marine System2008，72，14： | 1 |
| 7 | Implication of SSAT by gene expression and genetic variation in suicide and major depression显示文摘 | Adolfo S Fuad G J arlath M | 2006 | Arch Gen Psychiatry2006，63，： | 1 |
| 8 | Effect of superoxide dismutase from bovine eryth - rocytes on different activity parameters in adjuvant - induced arthritis 显示文摘 | Adolfo G G Jorge H A Jose L O | 1999 | Archives of Medical Research1999，30，2： | 1 |
| 9 | Challenging the interoperability between computers in industry with MDAand SOA 显示文摘 | RICARDO J G ANTONIO G ADOLFO S G | 2006 | Computers in Industry2006，57，89： | 1 |
| 10 | The best for the guest:high Andean nurse cushions of Azorella madreporica enhance arbuscular mycorrhizal status in associated plant species显示文摘 | Angelica Casanova-Katny M Adolfo Torres-Mellado G A Cavieres L A | 2011 | Mycorrhiza2011，21，7： | 1 |
| 11 | The virus battkes: IFN induction of the antiviral state and mechanisms of viral evasion显示文摘 | Elevy D Adolfo G S | 2001 | Cytokine Growth Factor Rev2001，10，12： | 1 |
| 12 | Characterization of a mitochondrial-targeting signal in the PB2 protein of influenza viruses 显示文摘 | Simon M C Elena C Adolfo G S | 2006 | Virology2006，344，2： | 1 |
| 13 | Enhanced Excitability Compen- sates for High-Pressure-Induced Depression of Cortical Inputs to the Hippocampus显示文摘 | ADOLFO E T YORAM G | 2004 | Journal of Neurophysiology2004，92，6： | 1 |
| 14 | Ontometeric:A method to choose the appropriate ontology显示文摘 | Adolfo Lozano-Tello Asunción Gómez-Pérez | 2004 | Journal of Database Management2004，15，2： | 1 |
| 15 | Multifractal analysis of soil spatial variability 显示文摘 | Adolfo N D P Daniel G Marco B | 1999 | Agronomy Journal1999，91，6： | 1 |
| 16 | Knowledge accumulation through automatic merging of ontology 显示文摘 | ADOLFO G A CUEVAS A D | 2010 | Expert Systems with Applications2010，37，3： | 1 |
| 17 | Comparison of methods for determination of vitamin B12 in microbical material显示文摘 | Adolfo Quesada-Chanto Adriane C Schmid-Meyer Adriana G Schroeder | 1998 | Biotechnology Techniques1998，12，1： | 1 |
| 18 | Effect of superoxide dis- mutase from bovine erythrocytcs on different activity parameters in adjuvant - induced arthritis 显示文摘 | ADOLFO G G JORGE H A JOSE L O | 1999 | Archives of Medical Research1999，30，2： | 1 |
| 19 | Knowledge Accumulation through Automatic Merging of Ontologies显示文摘 | Adolfo G A Cuevas A D | 2010 | Expert Systems with Applications2010，37，3： | 1 |
| 20 | Multiple anti-interferon actions of the influenza a virus NS1 protein显示文摘 | Georg K Adolfo G S Luis M S | 2007 | Journal of Virology2007，81，13： | 1 |
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