|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism显示文摘肿瘤坏死因素(TNF ) 联系了导致 apoptosis ligand (TRAIL/APO2L ) 是在血缘的死亡受体的约会之上导致 apoptosis 的 TNF 基因总科的一个成员。当小道对正常房间相对无毒时,它有选择地在许多转变房间导致 apoptosis。不过,胸肿瘤房间对小道的效果特别地抵抗。这里,我们报导在有 cyclin 依赖的 kinase 禁止者 roscovitine 的联合,落后于的暴露在检验的小道抵抗的乳癌房间线的多数导致了显著 apoptosis。Roscovitine 便于小道导致死亡的发信号的复杂形成和 caspase-8 的激活。FLICE 禁止的蛋白质是的 cFLIP (L) 和 cFLIP 显著地下面调整的列在后面暴露到 roscovitine 并且,确实由 siRNA 的 cFLIP isoforms 击倒敏化的胸肿瘤房间到导致小道的 apoptosis。另外,我们证明 roscovitine 强烈在胸肿瘤房间压制了 Mcl-1 表示和起来调整的 E2F1 蛋白质层次。显著地,由 siRNA 的 Mcl-1 的 silencing 敏化胸肿瘤房间到导致小道的 apoptosis。而且,由减少的 siRNA 的 E2F1 蛋白质击倒在导致小道的 apoptosis 的 roscovitine 的敏化的效果。在摘要,我们的结果为 roscovitine 的 pro-apoptotic 影响揭示 pleitropic 机制,加亮它象在在有小道的联合的乳癌的一个反肿瘤代理人的潜力。 | Gustavo Ortiz-Ferrón Rosario Yerbes Adriana Eramo Ana I López-Pérez Ruggero De Maria Abelardo Lápez-Rivas | 2008 | Cell Research2008，18，6： | 5 |
| 2 | Histone deacetylases,microRNA and leptin crosstalk in pancreatic cancer显示文摘Because pancreatic cancer(PC) historically has had poor prognosis and five year survival rates,it has been intensely investigated.Analysis of PC incidence and biology has shown a link between different risk factors such as smoking,alcoholism,and obesity and disease progression.Important factors affecting PC include the epigenomic changes driven by DNA methylation and histone acetylation,and actions of microRNA inducing oncogenic or tumor suppressor effects.Studies have identified markers whose dysregulation seem to play important roles in PC progression.PC markers involve classical histone deacetylases(HDAC),PC stem cell(PCSC),and leptin.In this review,we discuss the role of several PC biomarkers,and the potential crosstalk between HDAC,microRNA,and leptin in PC progression.Dysregulated expression of these molecules can increase proliferation,survival,PCSC,resistance to chemotherapy and tumor angiogenesis.The potential relationships between these molecules are further analyzed using data from The Cancer Genome Atlas and crosstalk pathways generated by the Pathway Studio Platform(Ariadne Genomics,Inc.).Oncogenic miRNA21 and tumor suppressor miRNA200 have been previously linked to leptin signaling.Preliminary analysis of PC biopsies and signaling crosstalk suggests that the main adipokine leptin could affect the expression of microRNA and HDAC in PC.Data analysis suggests that HDAC-microRNA-leptin signaling crosstalk may be a new target for PC therapy. | Cynthia I Tchio Mantho Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，3： | 2 |
| 3 | Model for end-stage liver disease-Na score or Maddrey discrimination function index, which score is best?显示文摘AIM: To compare the ability of model for end-stage liver disease(MELD)-Na and Maddrey discrimination function index(DFI) to predict mortality at 30 and 90 d in patients with alcoholic hepatitis(AH).METHODS: We prospectively assessed 52 patients with AH. Demographic, clinical and laboratory parameters were obtained. MELD-Na and Maddrey DFI were calculated on admission. Short-term mortality was assessed at 30 and 90 d. Receiver operating characteristic curve analysis was performed. RESULTS: Thirty-day and 90-d mortality was 44% and 58%, respectively. In the univariate analysis, sodium levels was associated with mortality at 30 and 90 d(P = 0.001 and P = 0.03). Child stage, encephalopathy, ascites, or types of treatment were not associated with mortality. MELD-Na was the only predictive factor for mortality at 90 d. For 30-d mortality area under the curve(AUC) was 0.763(95%CI: 0.63-0.89) for Maddrey DFI and 0.784 for MELD-Na(95%CI: 0.65-0.91, P = 0.82). For 90-d mortality AUC was 0.685(95%CI: 0.54-0.83) for Maddrey DFI and 0.8710 for MELD-Na(95%CI: 0.76-0.97, P = 0.041). CONCLUSION: AH is associated with high shortterm mortality. Our results show that MELD-Na is a more valuable model than DFI to predict short-term mortality. | Mercedes Amieva-Balmori Scherezada María Isabel Mejia-Loza Roberto Ramos-González Felipe Zamarripa-Dorsey Eli García-Ruiz Nuria Pérez y López Eumir I Juárez-Valdés Adriana López-Luria José María Remes-Troche | 2015 | World Journal of Hepatology2015，7，17： | 2 |
| 4 | 设计工程:软性基础设施——以墨西哥城的Texcoco公园为例显示文摘在当代的新形势下,城市地区必须探索新的实践和工程模式。Texcoco生态公园是一个关于城市如何重新构想和协调土地和生态复杂性的案例。该项目位于墨西哥城的生态区内,它揭示和探究了传统的建筑学方法如何无法应对大都市区所面临的复杂问题。Texcoco生态公园意在成为世界上最大的城市公园,同时设法解决当下墨西哥峡谷所面临的水危机。认识到水作为主要的组织元素,该项目提出两大主要策略来解决最具挑战性的问题。这两大策略是:'平衡'和'多任务'。这个公园同时作为一个软性基础设施,一种更加复杂的结构,而不是单一功能的支持系统。最后,该项目提出为区域未来发展所需的四个系统:栖息地系统、社会发展项目系统、交通系统和能源系统。 | I?aki Echeverria Adriana Chávez 陈雨虹 刘雅琦 | 2015 | 南方建筑2015，，4： | 1 |
| 5 | Hypoxia inducible factor-1:oxygen regulation of trophoblast differentiation in normal and preeclamptic pregnancies a review显示文摘 | Aniggia I Winter JL Adriana | 2002 | Placenta2002，23，： | 1 |
| 6 | Synthesis of mixed alkylphosphites and alkylphos- phates显示文摘 | GHEORGHE I ADRIANA P SMARAANDA I | 2003 | Phosphorus Sulfur and Silicon and the Related Elements2003，178，7： | 1 |
| 7 | Optimization of the operating parameters using RSM for the Fenton oxidation process and adsorption on vegetal carbon of MO solutions显示文摘 | Adriana S R Ricardo G S Manuel I M R | 2014 | Journal of Industrial and Engineering Chemistry2014，20，3： | 1 |
| 8 | On fully decentralized resource discovery in grid environments显示文摘 | Ian F Adriana I | 2001 | Lecture Notes In Computer Science2001，2242，： | 1 |
| 9 | Assessment of ven- tricular dissynchrony in right ventricular single chamber pacing using echocardiografic parameters显示文摘 | Vita I Adriana Mitre Dobreanu D | 2014 | Acta Medica Marisiensis2014，60，2： | 1 |
| 10 | Mapping the Gnutella network: properties of large-scale peer-to-peer systems and implications for system design显示文摘 | MATEI R IAN F ADRIANA I | 2002 | IEEE Internet Computing2002，6，1： | 1 |
| 11 | Development of a method to determine Ni and CA in biodiesel by graphite furnace atomic absorption spectrometry 显示文摘 | Fabiana A L I)anielle G Adriana P O | | Fuel0，90，1： | 1 |
| 12 | Use of sequential extraction to assess the influence of sewage sludge amendment on metal mobility in Chilean soils显示文摘 | Ahumada I Escudero P Adriana C | 2004 | Journal of Environmental Monitoring2004，6，4： | 1 |
| 13 | Determination of the fractal dimension of the lysozyme backbone of three different organisms显示文摘 | Adriana I Licz A Laura U | 2001 | Chaos Solitons and Fractals2001，，12： | 1 |
| 14 | Sistema glutamatergico Ⅱ : alteraciones en isquemia, alzheimer y esquizofrenia 显示文摘 | Hemdn J Pimienta Jimenez Adriana M Medina Marin Martha I Betancourth | 2003 | Revista Colombiana de Psiquiatria2003，32，1： | 1 |
| 15 | Detennlnation of the fractal dimension of the lysozyme backbone of three different or ganisms 显示文摘 | Adriana I I icaz A Laura U | 2001 | Chaos Solitons and Fractals2001，12，： | 1 |
| 16 | Determination of the fractal dimension of the lysozyme backbone of three different organisms显示文摘 | Adriana I Licz A Laura U etal | 2001 | Chaos Solitons and Fractals2001，12，： | 1 |
| 17 | Determination of the fractal dimen- sion of the lysozyme backbone of three different organisms 显示文摘 | Adriana I Licz A Laura U | 2001 | Chaos Solitons and Fractals2001，12，4： | 1 |
| 18 | Grey-box identification of air-handling unit elements 显示文摘 | Christian G Adriana C Christian I | 2007 | Control Engineering Practice2007，15，： | 1 |
| 19 | An integrated and cooperative architecture for multi-intersection traffic signal control显示文摘Traffic signal control(TSC)systems are one essential component in intelligent transport systems.However,relevant studies are usually independent of the urban traffic simulation environment,collaborative TSC algorithms and traffic signal communication.In this paper,we propose(1)an integrated and cooperative Internet-of-Things architecture,namely General City Traffic Computing System(GCTCS),which simultaneously leverages an urban traffic simulation environment,TSC algorithms,and traffic signal communication;and(2)a general multi-agent reinforcement learning algorithm,namely General-MARL,considering cooperation and communication between traffic lights for multi-intersection TSC.In experiments,we demonstrate that the integrated and cooperative architecture of GCTCS is much closer to the real-life traffic environment.The General-MARL increases the average movement speed of vehicles in traffic by 23.2%while decreases the network latency by 11.7%. | Qiang Wu Jianqing Wu Bojian Kang Bo Du Jun Shen Adriana Simona Mihăiţă | 2023 | Digital Transportation and Safety2023，2，2： | 0 |
| 20 | 制革工业产生的毛废弃物与脱墨污泥及城市污水处理系统污泥的共堆肥显示文摘由于采用保毛脱毛技术,制革工业产生的毛废弃物量是逐年增加的,这使得制革人员还要处理另一种固体废弃物。对于毛的利用已经提出了多种潜在的方案,其中,由于毛含氮量高,因此,将毛废弃物转变为农用肥料将是最有前景的应用方法之一。可通过堆肥进一步提高毛的农用价值。本文研究了牛皮加工中脱毛工序产生毛废弃物的堆肥。研究结果表明:毛废弃物不能单独堆肥,也不可与脱墨污泥这种作为化学补充的共同基质进行堆肥。当毛废弃物与城市污水处理系统原污泥以1:1、1:2和1:4质量比在实验室和试难工厂进行共堆肥时,能得到好的结果。在这些情况中,堆肥工艺结束时,均能得到更稳定的产品。试验工厂堆肥可通过测定取样时工艺温度(SRIT)和37℃(SRI37)时的静志呼吸指数而有效监控。特别指出,SRIT值对生物活性的变化更敏感。相对而言,呼吸商数(RQ)值并不是与工艺过程的进行同步的。 | Raquel Barrena Estel.la Pagans Adriana Artola Fel i citas V a zquez Antoni S a nchez 龚英(译) | 2010 | 北京皮革(中外鞋讯)(下)2010，，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员