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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Ki - ras Mutation and Io53 overexpression predict the clinical behavior of colorectal canc- er: A southwest oncology group study显示文摘 | AHNEN D J FEIGL P QUAN G | 1998 | Cancer Res1998，58，6： | 1 |
| 3 | The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum 显示文摘 | Wallace K Grau MV Ahnen D | 2009 | Cancer Epidemiol Biomarkers Prev2009，18，8： | 1 |
| 4 | Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease: follow-up of a randomized controlled trial显示文摘 | Spechler S J Lee E Ahnen D | 2001 | JAMA2001，285，： | 1 |
| 5 | Benign recurrent intrahepatic eholestasis : treatment with S-adenosyl- methionine 显示文摘 | Everson GT Ahnen D Harper PC | 1989 | Gastroenterology1989，96，51： | 1 |
| 6 | A randomized trial of aspirin to prevent colorectal adenomas显示文摘 | Baron JA Cole BF Sandler RS Haile RW Ahnen D Bresalier R McKeown-Eyssen G Summers RW Rothstein R Burke CA Snover DC Church TR Allen JI Beach M Beck GJ Bond JH Byers T Greenberg ER Mandel JS Marcon N Mott LA Pearson L Saibil F van Stolk RU | 2003 | N Engl J Med2003，348，10： | 1 |
| 7 | The association of lifestyle and dietary factors with the risk for serrated polyps of the colorectum 显示文摘 | WALLACE K GRAU M V AHNEN D | 2009 | Cancer Epidemiol Biomarkers Prey2009，18，8： | 1 |
| 8 | Review article: potential gastrointestinal effects of long - term acid suppression with proton pump inhibitors显示文摘 | Laine L Ahnen D McClain C | 2000 | Aliment Pharmacol Ther2000，14，6： | 1 |
| 9 | Review article: potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors显示文摘 | Laine L Ahnen D McClain C | 2000 | Aliment Pharmacol Ther2000，14，6： | 1 |
| 10 | Helicobacer pylori in peptic ulcer disease显示文摘 | Yamada T Ahnen D Alpers DH | 1994 | JAMA1994，272，： | 1 |
| 11 | Long-term outcome ofmedical and surgical therapies for gastroesophageal reflux dis- ease: follow-up of a randomized controlled trial 显示文摘 | Spechler S J Lee E Ahnen D | 2001 | JAMA2001，285，： | 1 |
| 12 | Adenomatous polyps of the colon显示文摘 | Levine J S Ahnen D J Clinical P | | 0，，： | 1 |
| 13 | Review article: potential gastrointestinal effects of long-term acid suppression with proton pump inhibitors显示文摘 | LAINE L AHNEN D McCLAIN C | 2000 | Aliment Pharmacol Ther2000，14，6： | 1 |
| 14 | Long term outcome of medical and surgical therapies for gastroesophageal reflux disease:follow up of a randomized controlled trial显示文摘 | Spechler ST Lee E Ahnen D | 2001 | JAMA2001，285，： | 1 |
| 15 | Serrated lesions of the colorectum: re-view and recommendations from an expert panel 显示文摘 | Rex D K Ahnen D J Baron J A Batts K P Burke C A Burt R W | 2012 | Am J Gastroenterol?2012，107，： | 1 |
| 16 | Benign recurrent intrahepatic cholestasis: treatment with S-adenosylmethionine显示文摘 | Everson GT Ahnen D Harper PC | 1989 | Gastroenterology1989，96，51： | 1 |
| 17 | Benign recurrent intrahepatic cholestasis: treatment with S-adenosylmethionine 显示文摘 | Everson GT Ahnen D Harper PC | 1989 | Gastroenterology1989，96，51： | 1 |
| 18 | Long-term outcome of medical and surgical therapies for gastroesophageal reflux disease显示文摘 | Spechler SJ Lee E Ahnen D | 2001 | LAMA2001，，285： | 1 |
| 19 | One-time screening for colorectal cancer with combined fecal occult blood testing and examination of the distal colon显示文摘 | LIEBERMAN D A HARFORD W V AHNEN D J | 2001 | N Engl J Med2001，345，8： | 1 |
| 20 | Benign recurrent intrahepatic cholestasis: treatment with S-adenosylmethionine 显示文摘 | Everson GT Ahnen D Harper PC | 1989 | Gastroenterology1989，96，51： | 1 |
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