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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 3 | The biology and demographic parameters of Aedes albopictus in northern peninsular Malaysia显示文摘Objective:To generate life table characteristics for the dengue vector Aedes albopictus(A. albopictus) under uncontrolled conditions,incorporating both the aquatic and the adult stages. Methods:Ten females derived from wild pupae were allowed to fully blood-feed on restrained mice.774 eggs were hatched in seasoned water.F1 larvae were followed for development until their F2 counterparts emerged as adults.Some population parameters were monitored(Fl) or estimated(F2).Results:A.albopictus exhibited increased fecundity and egg hatch success. Immature development was quick.Immature survival was high,with lowest rate in the pupal stage.Adult emergence was about 81%and sex ratio was close to 1:1.Generational mortality(K) was about 28%.A high proportion of females completed a reproductive cycle and the obtained parity rate was predicted to lead to higher fecundity in the next generation.Conclusios:It can be concluded that natural A.albopictus populations in Penang seem largely determined by quick development in combination with low immature loss and increased oviposition. | H Nur Aida Hamady Dieng Abu Hassan Ahmad Tomomitsu Satho AT Nurita MR Che Salmah Fumio Miake B Norasmah | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 2 |
| 4 | Serum apolipoprotein B-100concentration predicts the virological response to pegylated interferon plus ribavirin combination therapy in patients infected with chronic hepatitis C virus genotype lb显示文摘 | Yoshizawa K Abe H Aida Y | 2013 | J Med Virol2013，85，7： | 1 |
| 5 | Ab initio hydrogen transfer of glycine tau QM/MM-MC study on tomerlzatlon solution:helmholtz energy changes along water-mediated and direct processes显示文摘 | Miyamoto H Aida M | 2013 | Chem Lett2013，42，6： | 1 |
| 6 | Genes involved in organ separation in Arobidopsis: an analysis of the cup-shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | The Plant cell1997，9，6： | 1 |
| 7 | Genes involved in organ separation in Arabidopsis: an analysis of the cup - shaped cotyledon mutant 显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，6： | 1 |
| 8 | Isoliquiritigenin:a new aldose reductase inhibitor from Glycyrrhizae radix显示文摘 | Aida K Tawata M Shindo H | 1990 | Planta Med1990，56，3： | 1 |
| 9 | Serum immunoreactive collagen IV detected by monoclonal antibodies as a marker of severe fibrosis in patients with non-alcoholic fatty liver disease显示文摘 | Aida Y Abe H Tomita Y | 2015 | J Gastrointestin Liver Dis2015，24，1： | 1 |
| 10 | Contrast-enhanced MRI of an early preosseous lession of fibrodysplasia ossificans progressiva in a 21-month-old boy显示文摘 | Hagiwara H Aida N Machida J | 2003 | Am J Roentgenol2003，181，4： | 1 |
| 11 | Fundamental Research on Gear Noise and Vibration显示文摘 | H Fukuma T Furukawa and T Aida | 1973 | Bulletin of JSME1973，，： | 1 |
| 12 | Genes involved in organ separation in Arabidopsis, analysis of the cupshaped cotyledon mutant显示文摘 | AIDA M ISHIDA T FUKAKI H FUJISAWA H TASAKA M | 1997 | The Plant Cell1997，9，： | 1 |
| 13 | Genes involved in organ separation in Arabidopsis : an analysis of the cup- shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，： | 1 |
| 14 | Renal subcapsular hematoma ofter lumbar plexus block 显示文摘 | Aida S Takahashi H Shimoji K | 1996 | Anesthesiology1996，84，2： | 1 |
| 15 | Catalytical Conversion of Fructose and Glucose into 5-Hydroxymethylfurfural in Hot Compressed Water by Microwave Heating显示文摘 | QI X H WATANABE M AIDA T M | 2008 | Catalysis Communications2008，9，13： | 1 |
| 16 | Performance evaluation model for scheduling in a global computing system显示文摘 | AIDA K TAKEFUSA A NAKADA H | 2000 | The International Journal of High Performance Computing Applications2000，14，3： | 1 |
| 17 | Scaling up data mining algo- rithms: Review and taxonomy显示文摘 | Nicolas G P Aida D H G | 2012 | Process in Artificial In- telligence2012，1，1： | 1 |
| 18 | Anesthetic management with sevoflurane for internal fixation of long bone fracture in a horse 显示文摘 | Ohashi N Aida H | 1996 | J Equine Sci1996，7，： | 1 |
| 19 | Modeling the gain degradation of high concentration erbium-doped fiber amplifiers by introducing inhomogeneous cooperative up-conversion显示文摘 | Masuda H Takada A Aida K | 1992 | IEEE J Lightwave Technol1992，10，12： | 1 |
| 20 | Steroidogenic activities of follicle - stimulating hormone in the ovary of Japanese eel, Anguilla ja- ponica 显示文摘 | Kamei H Kaneko T Aida K | 2006 | General and Comparative Endocrinology2006，146，2： | 1 |
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