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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 3 | Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project显示文摘AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated children.METHODS:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to < 10,10 to < 15 and ≥ 15 years respectively compared to those < 5 years and 1.1 among girls compared to boys with P < 0.01. HBs Ag was positive in 0.11% and breakthrough infection was 0.36% and 0.39% depending on positivity of anti-HBc and DNA detection respectively. The prevalence of HBV infection was significantly higher among children aged ≥ 7 years(0.59%) compared to 0.07% among younger children with odds ratio equal to 8.4(95%CI:1.1-64.2) and P < 0.01.The prevalence was higher among girls(0.48%) than boys(0.29%) with P > 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory. | Iman I Salama Samia M Sami Zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally | 2015 | World Journal of Hepatology2015，7，22： | 2 |
| 4 | Ab initio hydrogen transfer of glycine tau QM/MM-MC study on tomerlzatlon solution:helmholtz energy changes along water-mediated and direct processes显示文摘 | Miyamoto H Aida M | 2013 | Chem Lett2013，42，6： | 1 |
| 5 | Isolation ofcDNA encoding a putative chitinase precursor in thekuruma prawn Penaeus japonicus 显示文摘 | Watanabe T Kono M Aida K | 1996 | MolecularMarine Biology and Biotechnology1996，5，4： | 1 |
| 6 | Genes involved in organ separation in Arobidopsis: an analysis of the cup-shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | The Plant cell1997，9，6： | 1 |
| 7 | Genes involved in organ separation in Arabidopsis: an analysis of the cup - shaped cotyledon mutant 显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，6： | 1 |
| 8 | Analysis of raw meats and fats of pigs using polymerase chain reaction for Halal authentication 显示文摘 | Aida A A Che Man Y B Wong C M V L | 2005 | Meat Science2005，69，： | 1 |
| 9 | Isoliquiritigenin:a new aldose reductase inhibitor from Glycyrrhizae radix显示文摘 | Aida K Tawata M Shindo H | 1990 | Planta Med1990，56，3： | 1 |
| 10 | Improving the superplastic properties of a two-phase Mg-8 % Li alloy through processing by ECAP显示文摘 | FURUI M XU C AIDA T | 2005 | Materials Science and Engineering2005，，： | 1 |
| 11 | Ab initio molecular orbital study on the pai- ring and stacking interactions between nucleic acid bases in rela- tion to the biological activities 显示文摘 | Nagata C Aida M | 1988 | J Mol Struct1988，179，1： | 1 |
| 12 | Influence of deposition temperature on structural, optical and electrical properties of sputtered A1 doped ZnO thin films 显示文摘 | Mosbah A Aida M S | 2012 | J Alloy Compd2012，515，： | 1 |
| 13 | Genes involved in organ separation in Arabidopsis, analysis of the cupshaped cotyledon mutant显示文摘 | AIDA M ISHIDA T FUKAKI H FUJISAWA H TASAKA M | 1997 | The Plant Cell1997，9，： | 1 |
| 14 | Substrate temperature influence on ZnS thin films prepared by ultrasonic spray显示文摘 | Daranfed W Aida M S Hafdallah A | 2009 | Thin Solid Films2009，518，4： | 1 |
| 15 | Genes involved in organ separation in Arabidopsis : an analysis of the cup- shaped cotyledon mutant显示文摘 | Aida M Ishida T Fukaki H | 1997 | Plant Cell1997，9，： | 1 |
| 16 | Catalytical Conversion of Fructose and Glucose into 5-Hydroxymethylfurfural in Hot Compressed Water by Microwave Heating显示文摘 | QI X H WATANABE M AIDA T M | 2008 | Catalysis Communications2008，9，13： | 1 |
| 17 | Gonadotropin surge during spawning in male goldfish 显示文摘 | Kobayashi M Aida K Hanyu I | 1986 | General and Comparative Endocrinology1986，62，1： | 1 |
| 18 | Dehydration of d-glucose in high temperature water at pressures up to 80 MPa显示文摘 | Aida T M Sato Y Watanabe M | 2007 | The Journal of Supercritical Flu- ids2007，40，3： | 1 |
| 19 | Anti-platelet action of isoliquiritigenin,an aldose reductase inhibitor in licorice显示文摘 | Tawata M Aida K Noguehi T | 1992 | Eur J Pharmaeol1992，212，1： | 1 |
| 20 | Identification of bovine invariant chain (Ii) gene by nucleotide sequencing 显示文摘 | Niimi M Nakai Y Aida Y | 1996 | Biochem Biophys Res Commun1996，222，1： | 1 |
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