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| 1 | Apoptosis and DNA damage in human spermatozoa显示文摘DNA 损坏经常在 subfertile 男性的精子被遇到并且包括损害授精与不利临床的结果的一个范围被相关,破坏 preimplantation 胚胎的开发,流产的增加的率和在子孙的疾病的提高的风险。在人的精子的 DNA 破碎的病原学密切与氧化的底的外观被相关使内收并且损害精子形式的证据。我们假设那个氧化压力阻碍精子形式,与糟糕改变的染色质导致精子的产生。这些有缺点的房间有一个趋势默认到线粒体与活动性损失, caspase 激活, phosphatidylserine exteriorization 和免费激进的产生的激活联系的一条 apoptotic 小径。后者导致类脂化合物 peroxidation 和氧化 DNA 损坏,它然后导致 DNA 破碎和房间死亡。精子的物理体系结构阻止从获得存取到原子 DNA 并且导致它的破碎由于这 apoptotic 进程激活的任何核酸酶。是为这个原因在人的精子遇到的 DNA 损坏的一个多数似乎氧化。给氧化应力似乎在 DNA 损坏的病原学有的重要角色,应该为在这个条件的处理的抗氧化剂有一个重要角色。如果在精子的氧化 DNA 损坏正在提供全身的氧化应力的敏感读出,这些调查结果的含意能在我们试着作为一篇序言在精子最小化 DNA 损坏到帮助概念治疗的立即的目标以外拉长。 | R John Aitken Adam J Koppers | 2011 | Asian Journal of Andrology2011，13，1： | 46 |
| 2 | Oxidative stress and male reproductive health显示文摘有缺点的精子功能的主要原因之一是氧化应力,它不仅破坏精子 DNA 的正直而且在精子血浆膜由于蛋白质和类脂化合物的并行的损坏限制这些房间的使肥沃的潜力。如此的氧化压力的起源看起来包含精子线粒体,它有一个趋势作为一篇序言产生 superoxide 阴离子的高水平到进入内在的 apoptotic 串联。不幸地,这些房间有很小的能力因为他们仅仅在基础切除修理(BER ) 拥有第一酶,对如此的攻击作出回应小径, 8-oxoguanine glycosylase 1 (OGG1 ) 。后者成功地创造一个 abasic 地点,而是精子因为他们缺乏下游的蛋白质,不能进一步处理氧化损害(APE1, XRCC1 ) 需要完成修理过程。在第一个有丝分裂的部门的 S 阶段的开始以前继续 BER 小径是卵母细胞的责任。如果一个错误被卵母细胞在开发的这个阶段犯,一个变化将被创造那将在身体在每个房间被代表。如此的机制可以在在作为年龄的后果在他们的细菌线承受了氧化应力的男性的后代观察的童年癌症和另外的疾病解释增加,环境或生活方式因素。在男不孕病人的精子的氧化 DNA 损坏的高流行可以为在 vitro 构思的孩子的健康有含意并且在细菌线为对免费激进的产生的起源的当前的研究担任一位司机。 | Robert J Aitken Tegan B Smith Matthew S Jobling Mark A Baker Geoffry N De Iuliis | 2014 | Asian Journal of Andrology2014，16，1： | 48 |
| 3 | Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?显示文摘这章探索 capacitation 和 apoptosis 是他们的普通依赖在反应的氧种类(ROS ) 的继续的产生上加入的连接过程的可能性。根据这个模型的意见, capacitation 在当细胞内部的 ROS 产生的后果,刺激细胞内部的营地产生,禁止酷氨酸磷酸酶活动并且由白朊从精子表面在他们的移动以前提高 oxysterols 的形成,跟随他们的版本进女繁殖的道的 spematozoa 被开始。由使能够的 ROS 的继续的产生精子的人口最后压到这些房间的有限能力保护自己免受氧化应力的伤害。作为精子的 over-capacitation 导致的结果,老朽的一个状态和截断的内在的 apoptotic 串联的激活由提高的 mitochondrial ROS 产生,类脂化合物 peroxidation,活动性损失, caspase 激活和 phosphatidylserine 外表表现描绘了。后者可能在指示吞噬细胞的白血球衰老的、垂死的精子的移动应该是由 proinflammatory cytokines 的产生无伴侣的一个沉默过程是特别地重要的。这些观察表明中央角色在定义精子的生活和死亡由氧化还原作用化学玩了。这些机制的知识可以帮助我们设计新奇答案专业化房间高度支持并且保存这些的功能。 | Robert J Aitken Mark A Baker Brett Nixon | 2015 | Asian Journal of Andrology2015，17，4： | 7 |
| 4 | Serum vitamin D content is associated with semen|parameters and serum testosterone levels in men显示文摘The present study aimed to evaluate the influence of serum vitamin D levels on semen quality and testosterone levels.This is a crosssectional study conducted at Androscience,Science and Innovation Center in Andrology and High-Complex Clinical and Andrology Laboratory in Sao Paulo,Brazil,with 508 male patients,aged 18-60 years,from 2007 to 2017.Seminal parameters and serum sexual hormones were correlated with serum vitamin D concentrations in 260 men selected by strict selection criteria.Patients were divided into normozoospermic group(NZG,n=124)and a group with seminal abnormalities(SAG,n=136).Evaluation included complete physical examination,past medical history,habits and lifestyle factors,two complete seminal analysis with sperm functional tests,serum levels of 25-hydroxy-vitamin D_(3)(25(OH)VD_(3)),total and free testosterone,luteinizing hormone(LH),follicle-stimulating hormone(FSH),sex hormone-binding globulin(SHBG),total cholesterol,homeostatic model assessment of insulin resistance(HOMA-IR)index,and karyotype.The mean concentration of 25(OH)VD_(3)was significantly lower in the SAG(P<0.001)and positively correlated with all baseline seminal parameters and total testosterone levels.In addition,serum vitamin D_(3)concentration was found to be positively correlated with sperm concentration(β=2.103;P<0.001),total number of spermatozoa with progressive motility(β=2.069;P=0.003),total number of motile spermatozoa(β=2.571;P=0.015),and strict morphology(β=0.056;P=0.006),regardless of other variables.This is the first comparative study to address the issue of serum vitamin D_(3)content between normozoospermic patients and those with sperm abnormalities.It clearly demonstrates a direct and positive relationship between serum vitamin D level and overall semen quality,male reproductive potential,and testosterone levels. | Inari M Ciccone Elaine MF Costa Juliana R Pariz Thiago A Teixeira Joel R Drevet Parviz Gharagozloo Robert J Aitken Jorge Hallak | 2021 | Asian Journal of Andrology2021，23，1： | 2 |
| 5 | Evaluation of a speetrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function 显示文摘 | Gomez E Irvine D S Aitken R J | 1998 | Int J Androl1998，21，2： | 1 |
| 6 | Redox regulation of tyro- sine phosphorylation in human spermatozoa and its role in human spermatozoa and its role in human sperm function 显示文摘 | Aitken R J Paterson M Fisher H | 1995 | J Cell Sci1995，108，： | 1 |
| 7 | Hippocrates on necrotising fasciitis显示文摘 | Descamps V Aitken J Lee MG | 1994 | Lance1994，344，8921： | 1 |
| 8 | Analysis of the ability of three probes targetin g the outer acrosomal membrane or acrosomal contents to detect the acrosome reac tion in human spermatozoa显示文摘 | Brindle J P | 1993 | Hum Reprod1993，8，10： | 1 |
| 9 | Mesorectal excision for rectal cancer显示文摘 | Aitken R J | 1996 | Br J Surg1996，83，2： | 1 |
| 10 | Generation of reactive oxygen species, lipid peroxidation and human sperm function 显示文摘 | Aitken R J Clarkson J S Fishel S | 1989 | Biol Re- prod1989，41，： | 1 |
| 11 | Precambrian biota from the Little Dal Group, Mackenzie Mountains, northwestern Canada显示文摘 | Hofmann H J Aitken J D | 1979 | Canadian Journal of Earth Sciences1979，16，1： | 1 |
| 12 | Do Domestic Firms Benefit from Direct Foreign Investment显示文摘 | | 1999 | American Economic Review1999，89，3： | 1 |
| 13 | Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa显示文摘 | Aitken R J Gordon E Harkiss D | 1998 | Biol Reprod1998，59，5： | 1 |
| 14 | Chromosome abnormalities in human embryos after in vitro fertilization 显示文摘 | Angell RR Aitken R J Van Look PF | 1983 | Nature1983，303，： | 1 |
| 15 | Safe handling of nanotechnology 显示文摘 | Maynard A Aitken R J Butz T | 2006 | Nature2006，444，7117： | 1 |
| 16 | A comparative study of oxidative DNA damage in mammalian spermatozoa 显示文摘 | Bennetts L E Aitken R J | 2005 | Mol Reprod Dev2005，71，： | 1 |
| 17 | Susceptibility to myoear- ditis is dependent on the response of alphabeta T lymphocytes to cox- sackieviral infection 显示文摘 | Opavsky MA Penninger J Aitken K | 1999 | Circ Res1999，85，6： | 1 |
| 18 | AFLP analysis of genetic diversity within Saccharum officinarum and comparison with sugarcane cultivars显示文摘 | Aitken K S Li J C Jackson P | 2006 | Australian Journal of Agricultural Research2006，57，11： | 1 |
| 19 | Do domestic firms benefit from direct investment? evidence from verezuela 显示文摘 | AITKEN B J HARRISON A E | 1999 | American Economic Review1999，89，3： | 1 |
| 20 | Swithing maternal dietary intake at the end of the first trimester has profound effects on placenta development and fetal growth in adolescent ewes carrying singleton fetuses显示文摘 | WALLACE J M BOURKE M D A AITKEN R P | 1999 | Biol Reprod1999，61，： | 1 |
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