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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Grading of renal cell carcinoma显示文摘 | Medeiros L J Jones E C Aizawa S | 1997 | Cancer1997，80，5： | 1 |
| 3 | Functional interplay between angiotensin Ⅱ and nitric oxide: cyclic GMP as a key mediator 显示文摘 | Yah C Kim D Aizawa T | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 4 | Direct uptake and degradation of DNA by lysosomes显示文摘 | Fujiwara Y Kikuchi H Aizawa S Furuta A Hatanaka Y Konya C | 2013 | Autophagy2013，9，8： | 1 |
| 5 | Living diatom assemblages from north Pacific and Bering Sea surface waters during summer 1999显示文摘 | AIZAWA C TANIMOTO M Jordan R W | 2005 | Deep-Sea Research: II2005，52，： | 1 |
| 6 | Functional interplay between angiotensin II and nitricoxide: cyclic GMP as a key mediator 显示文摘 | Yan C Kim D Aizawa T | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 7 | PPARgamma mediates high fat diet-induced adipocyte hypertrophy and insulin resistance显示文摘 | Kubota N Terauchi Y Miki H Tamemoto H Yamauchi T Komeda K Satoh S Nakano R I shii C Sugiyama T Eto K Tsubamoto Y Okuno A Murakami K Sekihara H Hasegawa G Naito M Toyoshima Y Tanaka S Shiota K Kitamura T Fujita T Ezaki O Aizawa S Nagai R T obe K Kimura S K | | 0，，： | 1 |
| 8 | Giant sacral schwannoma: a report of six cases显示文摘 | Pongsthorn C Ozawa H Aizawa T | 2010 | Ups J Med Sci2010，115，： | 1 |
| 9 | Neuronal degeneration and glinlcell-responses following trinethyl tin in toxication in the rat显示文摘 | Haga S Haga C Aizawa T | 2002 | Acta Neuropathol2002，103，6： | 1 |
| 10 | Detection and tracking of facial features by using edge pixel counting and deformable circular template matching 显示文摘 | de Silva L C Aizawa K Hatori M | 1995 | IEICE Transactions on Information and Systems1995，78，9： | 1 |
| 11 | Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator 显示文摘 | Yan C Kim D Aizawa T | 2003 | Arterioscler Tilromb Vasc Biol2003，23，1： | 1 |
| 12 | Functional interplay between an-giotensinⅡand nitric oxide:cyclic GMP as a key mediator显示文摘 | Yan C Kin D Aizawa T | 2003 | Arte-rioscler Thromb Vasc Biol2003，23，1： | 1 |
| 13 | Subband image coding with biorthogonal Wavelet显示文摘 | Cheong C K Aizawa k Saito T | 1992 | IEICE Trans on Fundamentals1992，，75： | 1 |
| 14 | Spatially controlled simultane-ous patterning of multiple growth factors in three-dimen-sional hydrogels显示文摘 | Wylie R G Ahsan S Aizawa Y Maxwell K L Mors-head C M Shoichet M S | 2011 | Nature Materials2011，10，10： | 1 |
| 15 | Characterization of the pufferfish Otx2 cisregulators reveals evolutionarily conserved genetic mechanisms for vertebrate head specification显示文摘 | Kimura-Yoshida C Kitajima K Oda-Ishii I Tian E Suzuki M Yamamoto M Suzuki T Kobayashi M Aizawa S Matsuo I | | 0，，01： | 1 |
| 16 | Neuronal degeneration and glial cell-responses following Trimethyltin intoxication in the rat 显示文摘 | Haga S Haga C Aizawa T | 2002 | Acta Neuropathol2002，103，6： | 1 |
| 17 | Functional interplaybetween angiotensin II and nitric oxide: cyclic GMP as akey mediator显示文摘 | Yan C Kim D Aizawa T | 2003 | Arterioscler Thromb Vase Biol2003，23，： | 1 |
| 18 | Giant sacral schwannoma:a report of six cases显示文摘 | Pongsthorn C Ozawa H Aizawa T | 2010 | Ups J Med Sci2010，115，2： | 1 |
| 19 | Functional interplay between angiotensin Ⅱ and nitric oxide: cyclic GMP as a key mediator 显示文摘 | Yan C Kim D Aizawa T | 2003 | Arterioscler Thromb Vasc Biol2003，23，1： | 1 |
| 20 | Detection and tracking of facial features by using edge pixel counting and deformable circular template matching 显示文摘 | De SILVA L C AIZAWA K HATORI M | 1995 | IEICE Transactions on Information and Systems1995，78，9： | 1 |
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