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| 1 | 黄芪总黄酮对扑热息痛所致小鼠肝损伤防护作用的研究显示文摘目的 :研究黄芪总黄酮 (TFA)对扑热息痛所致肝损伤的防护作用。方法 :用 1%羧甲基纤维素钠 10ml·kg-1,TFA10 0mg·kg-1或维生素C (Ascorbicacid ,VC) 10 0 0mg·kg-1给小鼠灌胃 1h后 ,灌扑热息痛 10 0 0mg·kg-1,观察小鼠死亡率的变化 ;提前 1h用不同剂量的TFA或VC处理后 ,再灌 40 0mg·kg-1的扑热息痛 ,检测血清酶学和肝脏组织学的改变。结果 :给小鼠扑热息痛 10 0 0mg·kg-1灌胃组 ,2 4h后可致 80 %小鼠死亡 ;提前 1h用TFA10 0mg·kg-1或VC灌胃其死亡率可分别下降至 2 0 %和 0 %。血清转氨酶 (ALT)和病理切片显示当给 40 0mg·kg-1扑热息痛灌胃 2 4h后即可引起严重肝损伤 (ALT升高和肝组织大面积坏死 ,P <0 .0 0 1)。TFA或VC预防组 (提前 1h给药 )的肝损伤程度与对照组比较明显减轻 ,其作用强度与药物浓度成正比。结论 :TFA对扑热息痛所致肝损伤有保护作用。 | 汪德清 丁保国 马艳青 赵海潞 Thomas G Neil Tomlinson Brian 田亚平 王成彬 Critchley Julian AJH | 2001 | 中国中药杂志2001，26，7： | 31 |
| 2 | 黄芪总黄酮对扑热息痛所致肝损伤的防护机理探讨显示文摘目的 :研究黄芪总黄酮对扑热息痛所致肝损伤的防护机理。方法 :用高压液相测定扑热息痛及代谢产物和苯巴比妥诱导睡眠模型研究黄芪总黄酮 (TFA)对扑热息痛的代谢及TFA抗扑热息痛所致损伤的机理。结果 :TFA可明显降低尿中硫醚胺酸的浓度 ,其变化与TFA浓度成反比 ;但对其它代谢产物的影响无明显统计学差异。苯巴比妥诱导小鼠睡眠实验结果显示 ,TFA (10 0mg·kg-1)本身对苯巴比妥代谢无明显影响 (P >0 .0 5 ) ,扑热息痛 (40 0mg·kg-1)可显著延长小鼠的睡眠时间 (P <0 .0 0 1) ;但TFA (10 0mg·kg-1)明显缩短扑热息痛所延长的苯巴比妥诱导的睡眠时间 (P <0 .0 0 5 )。结论 | 汪德清 Critchley Julian AJH 丁保国 马艳青 赵海潞 Thomas G Neil 田亚平 Tomlinson B rian Critchley Lester AH James Anthony Edward | 2001 | 中国中药杂志2001，26，9： | 13 |
| 3 | 阿托伐他汀对高脂血症患者血小板聚集反应的影响显示文摘观察降血脂药阿托伐他汀作用于高脂血症患者的血小板聚集反应。测试全血血小板聚集对各种诱导剂的反应性及实验的重复性 ,并选择胶原作为诱导剂进行全血血小板聚集反应检测。 30个高脂血症患者接受为期16周的治疗 ,用药剂量递增 ,从每日用药 10、2 0、40mg ,到 80mg ,均分别用药 4周 ,直至患者血脂水平达到靶水平以下。分别在最大剂量用药期及停药后 4周检测患者的血小板聚集反应、血小板计数、平均血小板体积、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇及甘油三酯水平。总胆固醇、低密度脂蛋白胆固醇及甘油三酯水平在停药后显著回升 (5 .0± 1.1、3.0± 1.0、2 .2± 3.3mmol/L比 9.0± 3.1、6 .8± 1.5、5 .0± 12 .4mmol/L ,P <0 .0 0 1)。与停药后 4周相比 ,在最大剂量用药期 ,患者全血血小板聚集反应显著降低 (自 19.0± 3.1Ω降至 17.1± 4.6Ω ,P <0 .0 5 ) ,而高密度脂蛋白胆固醇、血小板计数及平均血小板体积不受影响。表明阿托伐他汀能有效降低高脂血症患者的血脂水平及改善血小板聚集功能。 | 范伯丽 程颖 房家智 蒋宝琦 GNeil Thomas Julian AJH Critchley Brian Tomlinson | 2003 | 中国动脉硬化杂志2003，11，5： | 12 |
| 4 | Relationship between obesity and cardiovascular risk factors in elderly Chinese subjects显示文摘Objective To investigate the relative effects of degree and distribution of body fat with several cardiovascular disease (CVD) risk factors in elderly Chinese subjects.Methods One-hundred and thirty-five elderly Chinese individuals (age range, 60-65 y) without any history of significant renal, hepatic or cardiac disease were recruited. Seated blood pressure, anthropometric and fasting plasma biochemical parameters were measured. Student’s t-test was used to compare the differences in biochemical and anthropometric markers between cohorts.Results Males were heavier (64.6±8.6, 57.2±8.2?kg, P<0.001), taller (1.65±0.06, 1.51± 0.05 m, P<0.001) and their greater body fat was predominantly deposited centrally (Waist-to-hip ratio, 0.91±0.06, 0.88±0.07, P<0.05). Females were more generally obese with increased body mass index (BMI, 23.8±4.6, 25.0±3.5 kg/m 2, P<0.05) and percentage body fat [26.3% (24.5%-28.1%) vs 37.2% (36.0%-38.9%), P<0.001] than the males. However, despite an 11% higher proportion of body fat in females, no significant differences were identified in blood pressure, lipid profile, indices of insulin resistance or albumin-to-creatinine ratios.Conclusion It is likely that central adiposity contributes disproportionately to these metabolic disorders in males even though they are much leaner than elderly Chinese females. | G Neil THOMAS 赵海潞 马艳青 Wilson YS LEUNG Juliana CN CHAN Brian TOMLINSON Julian AJH CRITCHLEY 梁润成 陈重娥 汤宁信 郭志良 | 2002 | Chinese Medical Journal2002，，6： | 11 |
| 5 | Circulating adhesion molecules in disease显示文摘 | Gearing AJH Newman W | 1993 | Immunology Today1993，14，10： | 2 |
| 6 | Circulating adhesion molecules in disease显示文摘 | GEARING AJH NEWMAN W | 1993 | Immunol Today1993，1，： | 1 |
| 7 | Selectivity of 3 - deoxy- 3 fluorothymidine and 2 - fluoro 7 2 - deoxy- D- glucos for tumor versus inflammation in a rodent model显示文摘 | Van Waarde A Cobben DCP Suurmeijer AJH | 2004 | J NUCL MED2004，45，： | 1 |
| 8 | Circulating adhesion molecules in disease显示文摘 | Gearing AJH Newman W | 1993 | Immunol Today1993，1，： | 1 |
| 9 | Effect of EMG feed back on paretic muscles and abnormal cocon traction in the hemiplegic arm,compared with conventional physical therapy显示文摘 | Prevo AJH | 1982 | Scand J Rehabil Med1982，14，： | 1 |
| 10 | A review of microwaves tor Ibod processing显示文摘 | AJH Sale | | 0，，04： | 1 |
| 11 | Energy balance of eight volunteers fed on diet supplemented with either lactitol or saccharose 显示文摘 | Van Es AJH De Groot L Vogt JE | 1986 | Br J Nutr1986，56，： | 1 |
| 12 | Metabolic imaging of patients with intracranial tumors; H-1MR spectroscopic imaging and PET显示文摘 | Luyten PR Macien AJH Heirdel W | 1990 | Radiology1990，176，3： | 1 |
| 13 | Development and evaluation of rapid urinary antigen detection tests for diagnosis of Penicilliosis Marneffei显示文摘 | Desakorn V Simpson AJH Wuthiekanun V | 2002 | Journal of Clinical Microbiology2002，40，9： | 1 |
| 14 | Circulating adhesion molecules in disease显示文摘 | Gearing AJH Newman W | 1993 | Immunology Today1993，14，10： | 1 |
| 15 | Solvent suppressed spatially resolved spectroscopy:an approach to high resolution NMR on a whole body MR system显示文摘 | Luyten PR Marien AJH Systma B | 1989 | J Magn Reson1989，9，1： | 1 |
| 16 | The expression of the adhension molecule-1 ICAM-1 VCAM-1 PECAM and E-selectin in human arteriosclerosis 显示文摘 | Davies MJ Gordon JL Gearing AJH | 1993 | J Pathol1993，17，3： | 1 |
| 17 | Circulating adhesion molecules in disease显示文摘 | Gearing AJH Newman W | 1993 | Immunology Today1993，14，： | 1 |
| 18 | Acute re-nal failure in patients with sepsis in a surgical ICU:predictive factors,incidence,co morbidity,and outcome显示文摘 | Eric AJH Norbert HL Raymond CV | 2003 | J Am Soc Nephrol2003，14，4： | 1 |
| 19 | Acute renal failure in patients with sepsis in a surgical ICU: predictive factors, incidence, comorbidity,and outcome显示文摘 | Eric AJH Norbert HL Raymond CV | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 20 | Circulating adhesion molecules indisease显示文摘 | Gearing AJH Newman W | 1993 | Immunol Today1993，14，10： | 1 |
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