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| 1 | Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation显示文摘BACKGROUND:Endoscopic therapy has been successful in the management of biliary complications after both deceased donor liver transplantation(DDLT) and living donor liver transplantation(LDLT).LDLT is thought to be associated with higher rates of biliary complications,but there are few studies comparing the success of endoscopic management of anastomotic strictures between the two groups.This study aims to compare our experience in the endoscopic management of anastomotic strictures in DDLT versus LDLT.METHODS:This is a retrospective database review of all liver transplant patients undergoing endoscopic retrograde cholangiopancreatography(ERCP) after liver transplantation.The frequency of anastomotic stricture and the time to develop and to resolve anastomotic stricture were compared between DDLT and LDLT.The response of anastomotic stricture to endoscopic therapy was also analyzed.RESULTS:A total of 362 patients underwent liver transplantation between 2003 and 2011,with 125 requiring ERCP to manage biliary complications.Thirty-three(9.9%) cases of DDLT and 8(27.6%) of LDLT(P=0.01) were found to have anastomotic stricture.When comparing DDLT and LDLT,there was no difference in the mean time to the development of anastomotic strictures(98±17 vs 172±65 days,P=0.11),likelihood of response to ERCP [22(66.7%) vs 6(75.0%),P=0.69],mean time to the resolution of anastomotic strictures(268±77 vs 125±37 days,P=0.34),and the number of ERCPs required to achieve resolution(3.9±0.4 vs 4.7±0.9,P=0.38).CONCLUSIONS:Endoscopic therapy is effective in the majority of biliary complications relating to liver transplantation.Anastomotic strictures occur more frequently in LDLT compared with DDLT,with equivalent endoscopic treatment response and outcomes for both groups. | Calvin HY Chan Fergal Donnellan Michael F Byrne Alan Coss Mazhar Haque Holly Wiesenger Charles H Scudamore Urs P Steinbrecher Alan A Weiss Eric M Yoshida | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，5： | 7 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 4 | Longevity of optically activated,high gain GaAs photoconductive semiconductor switches显示文摘 | Loubriel G M Zutavern F J Alan M | | 0，，： | 1 |
| 5 | Haematological manifestations in patients with severe acute respiratory syndrome:retrospective analysis显示文摘 | ALAN W U TO K F | 2003 | BJM2003，326，7403： | 1 |
| 6 | Longevity of optically activated, high gain GaAs photoconductive semiconductor switches显示文摘 | Loubriel G M Zutavern F J Alan M | 1998 | IEEE Trans on Plasma Science1998，26，5： | 1 |
| 7 | Self-assembly of mesoscopicatly ordered chromatic polydiacetylene/silica nanocomposites显示文摘 | Lu Y F Yi Y Alan A Lu M C | 2001 | Nature2001，410，： | 1 |
| 8 | Hydrological processes and chemical characteristics of low--alpine patterned wetlands, south--central New Zealand显示文摘 | Catherne C G Alan F M Katharine J M | 2010 | Journal of Hydrology2010，385，14： | 1 |
| 9 | Feasibility of combined solar thermal and ground source heat pump systems in cold climate, Canada 显示文摘 | FARZIN M R ALAN S F | 2013 | Energy and Buildings2013，61，： | 1 |
| 10 | Phylogeny, mor- phology and pathogenicity of diaporthe and phomopsis spe- cies on almond in Portugal 显示文摘 | Eugenio L F D Jorge M S Alan J L P | 2010 | Fungal Diversity2010，44，： | 1 |
| 11 | Shallow fault segmentation of the Alpine fault zone, New Zealand revealed from 2-D and 3- D GPR surveying显示文摘 | Alastair F M Alan G G Anna K | 2010 | Journal of Applied Geophysics2010，70，： | 1 |
| 12 | An experimental adaptive nulling receiver utilizing the sample matrix inversion algorithm with channel equalization 显示文摘 | Johnson J R Alan J F Aumann H M | 1991 | IEEE Transaction on Microwave theory and techniques1991，39，5： | 1 |
| 13 | IL10 Polymorphisms Are Associated with Airflow Obstruction in Severe ?^sub 1^-Antitrypsin Deficiency显示文摘 | DeMeo Dawn L Campbell Edward J Barker Alan F Brantly Mark L Eden Edward McElvaney N Gerard Rennard Stephen I Sandhaus Robert A Stocks James M Stoller James K Strange Charlie Turino Gerard Silverman Edwin K | 2008 | American Journal of Respiratory Cell and Molecular Biology2008，，1： | 1 |
| 14 | Social phobia and depression:prevalence and comorbidity显示文摘 | Maurice M Alan F | 2010 | J Psychosomatic Res2010，68，： | 1 |
| 15 | Fault zone deformation and displacement partitioning in mechanically layered carbonates:The Hidden Valley fault,central Texas显示文摘 | David A F Alan P M Ronald N Mc | 2011 | AAPG Bulletin2011，95，： | 1 |
| 16 | Longevity of optically activated, high gain GaAs photoconductive semiconductor switches 显示文摘 | Loubriel G M Zutavern F J Alan Mar et al | 1998 | IEEE Transactions on Plasma Science1998，26，5： | 1 |
| 17 | Social phobia and depression:prevalenceand comorbidity显示文摘 | Maurice M Alan F | | 0，，3： | 1 |
| 18 | Correlation of the tei index with invasive measurements of ventricular function in a porcine model显示文摘 | Jared C LaCorte Santos E Cabreriza David G Rabkin Beth F Printz Lindita Coku Alan Weinberg Welton M Gersony Henry M Spotnitz | 2003 | Journal of the American Society of Echocardiography2003，，5： | 1 |
| 19 | Solar photodegradation of dichloroacetic acid and 2,4-dichlorophenol using an enchanced photo- Fenton process 显示文摘 | Plgnatello F G T Alan F M Daniela | 2002 | Chemosphere2002，48，： | 1 |
| 20 | High-er Order s-to-z Mapping Functions and Their Applicationin Digitizing Continuous-Time Filters显示文摘 | ALAN M S KANESHIGE J T GROUTAGE F D | 1991 | Proceedings ofthe IEEE1991，79，11： | 1 |
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