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| 1 | 如何设计高质量针刺临床研究:基于证据的专家共识显示文摘本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。 | 张誉清 焦睿珉 Claudia M Witt 劳力行 刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟 刘保延 刘志顺 刘岩 郑晖 吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt | 2022 | 英国医学杂志中文版2022，25，6： | 7 |
| 2 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 3 | Protocol for resolving protein mixtures in CZE显示文摘 | Gordon M J Lee K J Zare R N | 1991 | Anal Chem1991，63，： | 1 |
| 4 | The Glaucoma Symptom Scale:a brief index of glaucoma-specific symptoms显示文摘 | Lee BL Gutierrez P Gordon M | 1998 | Arch Ophthalmol1998，116，7： | 1 |
| 5 | Myeloid progenitor cells lacking p53exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation显示文摘 | Jabbour A M Daunt C P Green B D Vogel S Gordon L Lee R S Silke N Pearson R B Vandenberg C J Kelly P N Nutt S L Strasser A Borner C Ekert P G | 2010 | Blood2010，115，2： | 1 |
| 6 | Large-grained poly-Si films on ZnO:Al coated glass substrates显示文摘 | LEE K Y MUSKE M GORDON I | 2008 | Thin Solid Films2008，516，20： | 1 |
| 7 | Testing the iron hypothesis in ecosystems of the equatorial Pacific Ocean 显示文摘 | Martin J H CoMe K H Johnson K S Fitzwater S E Gordon R M Tanner S J Hunter C N Elrod V A Nowicki J L Coley T L Barber R T Lindley S Watson A J Van Scoy K Law C S Liddicoat M I Ling R Stanton T Stoekel J Collins C Anderson A Bidigare R Ondrusek M Latasa M Millero F J Lee K Yao W Zhang J Z Friederich G Sakamoto C Chavez F Buck K Kolber Z Greene R Falkowski P Chisholm S W Hoge F Swift R Yangel J Turner S Nightingale P Hatton A Liss P Tindale N W | 1994 | Nature1994，371，6493： | 1 |
| 8 | Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 Is required for zinc-induced ras activation显示文摘 | Weidong WU Lee M Graves Gordon N | 2002 | Biol Chem2002，277，24： | 1 |
| 9 | A Resource-based View of Competitive Advantage at the Port of Singapore 显示文摘 | Gordon J R M Lee P M Lucas H C | 2005 | Journal of Strategic Information Systems2005，，14： | 1 |
| 10 | Sevoflurane general anesthesia: an alternative technique in the pediatric oral and maxillofacial surgery patient 显示文摘 | Lee M Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 11 | Sevoflurane General Anesthesia: An alternative technique in the pediatric oral and maxillofacial surgery patient 显示文摘 | Lee M S Bennett H E Gordon N | 2003 | J Oral Maxillofac Surg2003，61，： | 1 |
| 12 | A resource-based view of competitive advantage at the Port of Singapore 显示文摘 | JOHN R M GORDON PUI-MUN LEE HENRY C LUCAS JR | 2005 | Journal of Strategic Information Systems2005，14，1： | 1 |
| 13 | Sevoflurane general anesthesia : An alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | Lee M Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 14 | Laboratory simulation of terrestrial meteorite weathering using the Bensour(LL6)ordinary chondrite显示文摘 | Lee M R Smith C L Gordon S H | 2006 | Meteoritics&Planetary Science2006，41，8： | 1 |
| 15 | Protocol for resolving protein mixtures in capillary zone electrophoresis显示文摘 | Gordon M J Lee K J Arias A A | 1991 | Anal Chem1991，63，： | 1 |
| 16 | Sevoflurane general anesthesia:an alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
| 17 | Highly conserved non-coding elements on either side of SOX9 associated with Pierre Robin sequence显示文摘 | Benko S Fantes JA Amiel J Kleinjan DJ Thomas S Ramsay J Jamshidi N Essafi A Heaney S Gordon CT McBride D Golzio C Fisher M Perry P Abadie V Ayuso C Holder-Espinasse M Kilpatrick N Lees MM Picard A Temple IK Thomas P Vazquez MP Vekemans M Roest Crollius H | | 0，，03： | 1 |
| 18 | Sevoflurane general anesthesia: an alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | LEE M BENNETT HE GORDON N | 2005 | J Oral Maxillofac Surg2005，61，11： | 1 |
| 19 | Overexpression of kallikrein 10 in epithelial ovarian carcinomas显示文摘 | Hyun S Shvartsman Karen H Lu John Lee Jim Lillie Michael T Deavers Stephanie Clifford Judith K Wolf Gordon B Mills Robert C Bast David M Gershenson Rosemarie Schmandt | 2003 | Gynecologic Oncology2003，，1： | 1 |
| 20 | Sevoflurane general anes- thesia:an alternative technique in the pediatric oral and maxillofacial surgery patient显示文摘 | Lee M Bennett HE Gordon N | 2003 | J Oral Maxillofac Surg2003，61，11： | 1 |
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