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1篇 您的检索式：作者名="ALAN M. DIAMOND"

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		题名	作者	年代	出处	被引量
	1	A T-Cell Model for the Biological Role of Selenium-Dependent Glutathione Peroxidase显示文摘The cytosolic form of selenium-dependent glutathione peroxidase detoxifies both hydrogen and lipid peroxides and therefore represents a major component of the cellular anti-oxidant defenses. In order to study the biological role of this enzyme, we generated an expression construct in a retroviral vector, which when introduced into immortalized human T-cells, resulted in significant increases in the activity of this important enzyme. This effect is stable over extended maintenance in culture. The anti-oxidant defenses in these same cells are also shown to be attenuated hy chemically reducing cellular glutathione levels. Collectively, the abllity to both increase and decrease the anti-oxidant defenses in human T cells results in a useful model system for the study of oxidative stress and signaling in this cell	ALAN M. DIAMOND YASUSHI KATAOKA JUDITH MURRAY DUAN CHENGYING THOMAS M. FOLKST,AND PAUL. A. SANDSTROM(Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA Retrovirus Disease Branch, Division of Viral and Rickettsial	1997	Biomedical and Environmental Sciences1997，10，2：	0

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