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| 1 | Diagnostic and therapeutic challenges of gastrointestinal angiodysplasias: A critical review and view points显示文摘Gastrointestinal angiodysplasias (GIADs), also called angioectasias, are the most frequent vascular lesions. Its precise prevalence is unknown since most of them are asymptomatic. However, the incidence may be increasing since GIADs affect individuals aged more than 60 years and population life expectancy is globally increasing worldwide. They are responsible of about 5% to 10% of all gastrointestinal bleeding (GIB) cases. Most GIADs are placed in small bowel, where are the cause of 50 to 60% of obscure GIB diagnosed with video capsule endoscopy. They may be the cause of fatal severe bleeding episodes;nevertheless, recurrent overt or occult bleeding episodes requiring repeated expensive treatments and disturbing patient’s quality-of-life are more frequently observed. Diagnosis and treatment of GIADs (particularly those placed in small bowel) are a great challenge due to insidious disease behavior, inaccessibility to affected sites and limitations of available diagnostic procedures. Hemorrhagic causality out of the actively bleeding lesions detected by diagnostic procedures may be difficult to establish. No treatment guidelines are currently available, so there is a high variability in the management of these patients. In this review, the epidemiology and pathophysiology of GIADs and the status in the diagnosis and treatment, with special emphasis on small bowel angiodysplasias based on multiple publications, are critically discussed. In addition, a classification of GIADs based on their endoscopic characteristics is proposed. Finally, some aspects that need to be clarified in future research studies are highlighted. | Diego García-Compeán ángel N Del Cueto-Aguilera Alan R Jiménez-Rodríguez José A González-González Héctor J Maldonado-Garza | 2019 | World Journal of Gastroenterology2019，25，21： | 5 |
| 2 | Dietary approaches following endoscopic retrograde cholangiopancreatography: A survey of selected endoscopists显示文摘AIM: To describe the dietary recommendations of experienced endoscopists for patients who have undergone endoscopic retrograde cholangiopancreatography (ERCP) and the factors that influence these recommendations. METHODS: Selected U.S. endoscopists with ERCP experience were surveyed by e-mail. A questionnaire with three hypothetical ERCP cases of patients at low, medium and high risk for development of post-ERCP pancreatitis (PEP) was shown. For each scenario, respondents were asked to recommend a post-procedure diet and time to first oral intake. Respondents were also asked about the effect of various clinical factors on their recommendations, including risk of PEP.RESULTS: 97/187 selected ASGE members (51.9%) responded. When risk of PEP was either low, medium or high, 53%, 88% and 96% recommended a diet of clear liquids/NPO respectively, and 2%, 5% and 18% recommended delaying first oral intake until the following day. About 88% of respondents gave the same type of diet to patients at high as those with moderate-risk of PEP (P = 0.04). However, 37% and 43% of respondents gave different types of diet to patients at low vs moderate-risk and low-risk vs high-risk of PEP respectively (P < 0.001). No statistically significant associations were found regarding the effect of other clinical factors or respondent demographics.CONCLUSION: Most experienced endoscopists limit diet to NPO/clear liquids after ERCP for patients at high or moderate risk of post-ERCP pancreatitis. About half allow a low-fat or regular diet in patients at low risk. | Lincoln EVVC Ferreira Mark D Topazian William S Harmsen Alan R Zinsmeister Todd H Baron | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，12： | 3 |
| 3 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 4 | Seismic fragility assessment of SMA-bar restrained multi-span continuous highway bridge isolated by different laminated rubber bearings in medium to strong seismic risk zones显示文摘 | Alan M S Bhuiyan M A R Billah A H M | 2012 | Bulletin of Earthquake Engineering2012，10，6： | 1 |
| 5 | 3D reconstruction of the carotid artery from two views using a single centerline显示文摘 | Kenneth R H Alan M W Peter B N | 2004 | International Congress Series2004，，： | 1 |
| 6 | A randomized phase Ⅱ trial comparing two different sequence combinations of autologous vaccine and human recombinant interferon γ and human recombinant interferon α2b therapy in patients with metastatic renal cell carcinoma:clinical outcome and analysis of immunological parameters显示文摘 | Thomas S John A H Alan R S | 2000 | J Urology2000，163，： | 1 |
| 7 | Habitat loss,fragmentation,and restoration显示文摘 | Gray R H Alan H | 1999 | Restoration Ecology1999，7，3： | 1 |
| 8 | Classifying Geographical History 显示文摘 | Baker Alan R H | 2007 | The Professional Geographer2007，，3： | 1 |
| 9 | A novel micromachined pump based on thick-film piezoelectric actuation 显示文摘 | MICHAEL K NICK H ALAN G R | 1998 | Sens Actuators A1998，70，： | 1 |
| 10 | Self-oriented regular arrays of carbon nanotubes and their field emission properties显示文摘 | FAN S S CHAPLINE M G FRANKIN N R TOMBLER T W ALAN C M DAI H J | 1999 | Science1999，283，： | 1 |
| 11 | In vivo tracking of platelets:Circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function显示文摘 | Marc R B Herbert B H | 1996 | Med Sci1996，93，11： | 1 |
| 12 | 显示文摘 | Song M Y Alan D S Park H R | 1999 | Journal of Power Sources1999，83，12： | 1 |
| 13 | Protective effect ofdecorin on acute ischaemia-reperfusion injury in the rat kidney显示文摘 | ALAN C KOCOGLU H ALTINTAS R | 2011 | Arch Med Sci2011，7，2： | 1 |
| 14 | An experimental adaptive nulling receiver utilizing the sample matrix inversion algorithm with channel equalization 显示文摘 | Johnson J R Alan J F Aumann H M | 1991 | IEEE Transaction on Microwave theory and techniques1991，39，5： | 1 |
| 15 | The development of a standard method for determining oxidation induction times of hydrocarbon liquids by PDSC 显示文摘 | Pamela L S Gerald H P Alan T R | 1994 | Thermochimica Acta1994，，243： | 1 |
| 16 | A novelmicromachined pump based on thick-film piezoelectricactuation显示文摘 | MICHAEL K NICK H ALAN G R E | 1998 | Sensors and Actuators A:Physical1998，70，1： | 1 |
| 17 | Bladder cancer risk and personal hair dye use显示文摘 | ANGELINE S A ALAN R S JOHN A H | 2004 | Int J Cancer2004，109，4： | 1 |
| 18 | Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups 显示文摘 | Alan R H Carol B Martin J C | 2001 | Mech Ageing Dev2001，122，： | 1 |
| 19 | Synthesis of novel supermicroporous silicates by ω-hydroxy alkyl ammonium halide bolaform surfactant templating显示文摘 | Stephen A B Alan R H | 2001 | Microporous and Mesoporous Material2001，4445，： | 1 |
| 20 | Camosine, a protective, anti-ageing peptide? 显示文摘 | Alan R H | 1998 | The International Journal of Biochemistry & Cell Biology 19981998，，： | 1 |
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