|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | Exchange diffusion of Cu^2+,Ni^2+,Pb^2+ and Zn^2+ into analcime synthesized from perlite显示文摘 | Sudapom T Kunwadee R Alan Dyer | 2004 | Microporous and Mesoporous Materials2004，75，3： | 1 |
| 3 | The Information Systems Research Cycle 显示文摘 | Alan R Hevner Salvatore T Marcb | 2003 | IEEE Computer2003，36，11： | 1 |
| 4 | Self-oriented regular arrays of carbon nanotubes and their field emission properties显示文摘 | FAN S S CHAPLINE M G FRANKIN N R TOMBLER T W ALAN C M DAI H J | 1999 | Science1999，283，： | 1 |
| 5 | Betalain,acid ascorbic,phenolic contents and antioxidant properties of purple,red,yellow and white cactus pears显示文摘 | SUMAYA M M T CRUZ J S MADRIGAL S E GARCíA P CARIO C J CRUZ C R VALADEZ V MARTINEZ C C L ALANíS G E | 2011 | International Journal of Molecular Sciences2011，12，10： | 1 |
| 6 | ACC/ AHA 2005 practice guidelines for the management of patients with peripheral arterial disease ( lower extremity, renal, mesenteric, and abdominal aortic ) 显示文摘 | Alan T Ziv J Norman R | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 7 | ACC/AHA 2005 practice guidelines for the management of patients with peripheral arte rial disease (lower extremity, renal, mesenteric and abdominal aortic) 显示文摘 | Alan T Ziv J Norman R | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 8 | Effect of change of fecal bile acid excretion achieved by operative procedures on 1,2-dimethylhydrazine-induced colon cancer in rats显示文摘 | Krisztina Morvay Károly Szentléleki Géza T?r?k Alan Pintér Mátyás B?rzs?nyi Reinhard Nawroth | 1989 | Diseases of the Colon & Rectum1989，，10： | 1 |
| 9 | The development of a standard method for determining oxidation induction times of hydrocarbon liquids by PDSC 显示文摘 | Pamela L S Gerald H P Alan T R | 1994 | Thermochimica Acta1994，，243： | 1 |
| 10 | Loco-motive Assignment and Freight Train Scheduling UsingGenetic Algorithms显示文摘 | GODWIN T GOP ALAN R’NARENDRAN T T | 2006 | International Transactions in Op-erational Research2006，13，4： | 1 |
| 11 | Public transportation access 显示文摘 | ALAN T MURRAY R DAVIS R J | 1998 | Transportation Research Part D1998，3，5： | 1 |
| 12 | ACC/AHA 2005guidelines for the management of patients with per-ipheral arterial disease 显示文摘 | Alan T Ziv J Norman R | 2006 | Journal of the American College of Cardiology2006，47，6： | 1 |
| 13 | ACC/AHA 2005 Practice Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity,Renal,Mesenteric,and Abdominal Aortic)显示文摘 | Alan T Ziv J Norman R | 2006 | J Am Coll Cardiol2006，47，： | 1 |
| 14 | ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult Available显示文摘 | Alan T Iiv J Norman R | 2006 | Journal of the American College of Cardiology2006，47，6： | 1 |
| 15 | Sacral tuberculosis: a case report and review of the literature显示文摘 | John C Wellons Ali R Zomorodi Alan T Villaviciencio Christopher W Woods William T Lawson James D Eastwood | 2004 | Surgical Neurology2004，，2： | 1 |
| 16 | Mannose-bind- ing lectin and innate immunity 显示文摘 | Eddielp W K Kazue T Alan Ezekowitz R | 2009 | Immunol Rev2009，230，： | 1 |
| 17 | The expression of SOCS is altered in rheumatoid arthritis显示文摘 | Isomaki P Alan?r? T Isohanni P | 2007 | Rheumatology (Oxford)2007，46，10： | 1 |
| 18 | The REMATCH trial: rationale, design, and end points显示文摘 | Eric A Rose Alan J Moskowitz Milton Packer Josephine A Sollano Deborah L Williams Anita R Tierney Daniel F Heitjan Paul Meier Deborah Davis Ascheim Ronald G Levitan Alan D Weinberg Lynne Warner Stevenson Peter A Shapiro Ronald M Lazar John T Watson Daniel | 1999 | The Annals of Thoracic Surgery1999，，3： | 1 |
| 19 | Landfill liner interface strengths from torsional-ring-shear tests显示文摘 | T D Stark Alan R Poeppel | 1994 | Journal of Geotechnical Engineering1994，，3： | 1 |
| 20 | Ion exchange of Cu^2+,Ni^2+,Pb^2+ and Zn^2+ in analcime (ANA) synthesized from thai perlite显示文摘 | SUDAPORN T KUNWADEE R ALAN D | 2005 | Microporous Mater2005，79，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员