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20篇 您的检索式:作者名="ALBERTINI M C"
    题名 作者 年代 出处 被引量
1TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 2018神经损伤与功能重建2018,13,6:5
2Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse 显示文摘Combelles C M Albertini D F 2003Biology of Reproduction2003,68,3:1
3Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse显示文摘COMBELLES C M ALBERTINI D F 2003Biol Reprod2003,68,3:1
4Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy 显示文摘Teodori L Albertini M C Uguccioni F 2006Cytometry A2006,69,2:1
5Origins and manifestations of oocyte maturation competencies显示文摘Albertini D F Sanfins A Combelles C M 2003Reprod Biomed Online2003,6,4:1
6Melatonin reduces en- doplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia显示文摘Carloni S Albertini M C Galluzzi L et aI 2014J Pineal Res2014,57,2:1
7Mutations of the b-tubulin gene associated with different phenotypes of benzimidazole resistance in the cereal eyespot fungi Tapesia yallundae and Tapesia acutormis显示文摘Albertini C Gredt M Leroux P 1999Pestic Biochem Physiol1999,64,:1
8Study of the true tensile stress-straindiagram of plain concrete with real size aggregate: need for and designof a large Hopkinson bar bundle显示文摘Albertini C Montagnani M 1994Journal de Physique IV1994,,:1
9Mutations of the β-Tubulin Gene Associated with Different Phenotypes of Benzimidazole Resistance in the Cereal Eyespot Fungi Tapesia yallundae and Tapesia acuformis显示文摘ALBERTINI C GREDT M LEROUX P 1999Pest Bioc and Phys1999,64,:1
10Strain-rate effect of the tensile behavior of concrete at different relative humidity levels 显示文摘CADONI E LABIBES K ALBERTINI C BERRA M GIANGRASSO 2001Materials and Structures2001,34,1:1
11Microtubule patterning during meiotic maturation in mouse oocytes is determined by cell cycle-specific sorting and redistribution of Y-tubulin 显示文摘Combelles C M H Albertini D F 2001Dev Biol2001,239,2:1
12Cellular basis for paracrine regulation of ovarian follicle development显示文摘Albertini D F Combelles C M Benecchi E 2001Reproduction2001,121,:1
13Study of the true tensile stress-strain diagram of plain concrete with real size aggregate, need for and design of a large Hopkinson bar bundle 显示文摘Albertini C Montagnani M 1994Journal de Physique Ⅳ1994,,:1
14Surveillance of methicillin-resistant Staphylococcus aureus (MRSA) and Enterobacteriaceae producing extended-spectrum beta-lactamase (ESBLE) in Northern France: a five-year multicentre incidence study 显示文摘Albertini M T Benoit C Berardi L J Hosp0,,:1
15Mutations of the Prtubulin gene associated with different phenotypes of benzimidazole resistance in the cereal eyespot fungi Tapesia yallundae and Tapesia acuformis显示文摘Albertini C Gredt M Leroux P 1999Pestic Biochem Physiol1999,64,:1
16Melatonin as an apoptosis antagonist显示文摘RADOGNA F PATERNOSTER L ALBERTINI M C 2006Ann N Y Acad Sci2006,1090,12:1
17Mutations of the β-tubulin gene associated with different phenotypes of benzimidazole resistance in the cereal eyespot fungi Tapesia yallundae and Tapesia acuformis 显示文摘Albertini C Gredt M Leroux P 1999Pesticide Biochemistry and Physiology1999,64,1:1
18Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy 显示文摘TEODORI L ALBERTINI M C UGUCCIONI F 2006Cytometry A2006,69,2:1
19Cellu-lar basis for paracrine regulation of ovarian follicle de-velopment显示文摘Albertini D F Combelles C M Benecchi E 2001Reproduction2001,121,:1
20Static magnetic fields affect cell size, shape, orientation, and membrane surfaceof human glioblastoma cells, as demonstrated by electron, op- tic,and atomic force microscopy 显示文摘Teodori L Albertini M C Uguccioni F 2006Cytometry A2006,69,2:1
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