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| 1 | Therapeutic and prophylactic thalidomide in TNBS-induced colitis: Synergistic effects on TNF-α, IL-12 and VEGF production显示文摘AIM: To evaluated the therapeutic and prophylactic effect of thalidomide on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Thalidomide has been reported to downregulate the expression of tumor necrosis factor a (TNF-α), IL-12, and vascular endothelial growth factor (VEGF), hallmarks of intestinal inflammation in Crohn's disease (CD). METHODS: Male Wistar rats were divided in five groups of ten animals each. Four groups received a rectal infusion of TNBS in ethanol. The first group was sacrificed 7 d after colitis induction. The second and third groups received either thalidomide or placebo by gavage and were sacrificed at 14 d. The fourth group received thalidomide 6 h before TNBS administration, and was sacrificed 7 d after induction. The fifth group acted as the control group and colitis was not induced. Histological inflammatory scores of the colon were performed and lamina propria CD4+ T cells, macrophages, and VEGF+ cells were detected by immunohistochemistry. TNF-a and IL-12 were quantified in the supernatant of organ cultures by ELISA. RESULTS: Significant reduction in the inflammatory score and in the percentage of VEGF+ cells was observed in the group treated with thalidomide compared with animals not treated with thalidomide. Both TNF-αand IL-12 levels were significantly reduced among TNBS induced colitis animals treated with thalidomide compared with animals that did not receive thalidomide. TNF-αlevels were also significantly reduced among the animals receiving thalidomide prophylaxis compared with untreated animals with TNBS-induced colitis. Intestinal levels of TNF-αand IL-12 were significantly correlated with the inflammatory score and the number of VEGF+ cells. CONCLUSION: Thalidomide significantly attenuates TNBS-induced colitis by inhibiting the intestinal production of TNF-α, IL-12, and VEGF. This effect may support the use of thalidomide as an alternate approach in selected patients with CD. | Ana Teresa Carvalho Heitor Souza Antonio Jose Carneiro Morgana Castelo-Branco Kalil Madi Alberto Schanaider Flavia Silva Fernando Antonio Pereira Júnior Márcia G Pereira Cláudio Tortori Ilana Dines Jane Carvalho Eduardo Rocha Celeste Elia | 2007 | World Journal of Gastroenterology2007，13，15： | 6 |
| 2 | Management of Hemor- rhage in Trauma 显示文摘 | Herbert S Alberto G Christoph J | 2013 | J Cardiothorac Vasc Anesth2013，27，4： | 1 |
| 3 | Hydrolysis of sugar cane bagasse using nitric acid: a kinetic assessment 显示文摘 | Rodriguez - Chong A Alberto Ramirez J Garrote G | 2004 | Journal of food engineering2004，61，2： | 1 |
| 4 | Liquid phase hydrogenation of cinnamaldehyde on Cu-based catalysts 显示文摘 | Alberto J M Diego A G Andres F T | 2003 | Applied Catalysis A : General2003，249，： | 1 |
| 5 | The FTT-CAN protocol: why and how 显示文摘 | Almeida L Pedreiras P Alberto J G | 2002 | IEEE Transactions on Industrial Electronics2002，49，6： | 1 |
| 6 | Interfacial Properties of Zirconium Dioxide and Magnetite in Water显示文摘 | Regazzoni Alberto E Blesa Miguel A Maroto Alberto J G | 1983 | Journal of Colloid and Inte(ace Science1983，91，2： | 1 |
| 7 | Optimisation of medium composition for clavulanic acid production by Streptomyces clavuligerus显示文摘 | Ester R G Alvaro B N Alberto C B J | 2001 | Biotechnology Letters2001，23，： | 1 |
| 8 | Optimisation of me- dium composition for clavulanic acid production by Strep- tomyces clavuligerus 显示文摘 | Ester R G Alvaro B N Alberto C B J | 2001 | Biotechnology Letters2001，23，2： | 1 |
| 9 | Optimisation of Medium Composition for Clavulanic Acid Production by Streptomyces Clavuligerus显示文摘 | ESTER R G ALVARO B N ALBERTO C B J | 2001 | Biotechnology Letters2001，23，： | 1 |
| 10 | Optimisation of medium composition for clavulanic acid production by Streptomyces clavu-ligerus显示文摘 | Ester R G Alvaro B N Alberto C B J | | 0，，： | 1 |
| 11 | A Hybrid Genetical Gorithm for Optimal Reactive Power Planning Based Upon Successive Linear Programming显示文摘 | Alberto J U Juan F G Sorrentino E | 1999 | IEEE Trans on Power Systems1999，14，4： | 1 |
| 12 | Microencapsulation of cinnamon leaf (Cinnamomum zeylanicum) andgarlic {Allium sativum) oils in y9-cyclodextrin显示文摘 | FERNANDO J HERLINDA S ALBERTO G | 2008 | Journal of Inclusionphenomena and Macrocyclic Chemistry2008，60，3： | 1 |
| 13 | A fast and cost-effective approach to develop and map EST -SSR markers: oak as a case study 显示文摘 | Durand J Bodenes C Chancerel E Frigerio J M Vendramin G Sebastiani F Buonamici A Gailing 0 Koelewijn H P Villani F Mattioni C Cherubini M Goicoechea P G Herran A Ikaran Z Cabane C Ueno S Alberto F Dumoulin P Y Guichoux E Daruvar A Kremer A Plomion C | 2010 | BMCGenomics2010，11，： | 1 |
| 14 | Progress in chemical-looping combustion and reforming technologies显示文摘 | Adanez J Alberto A Francisco G L | 2012 | Progress in Energy and Combustion Science2012，38，： | 1 |
| 15 | Structural damage detection using the transformation matrix 显示文摘 | Alberto E J Jesus S J Roberto G | 2005 | Computers and Structures2005，83，45： | 1 |
| 16 | Recovery of Functional Impairment after Acute Illness and Mortality: One-Year Follow-Up Study显示文摘 | Baztán Juan J Gálvez César P Socorro Alberto | 2009 | Gerontology2009，，3： | 1 |
| 17 | Re tricarbonyl complexes with ligands containing P, N, N and P, N, O donor atom sets : Synthesis and structural characterization 显示文摘 | Correia J D G Domingos A Santos I Alberto R Ortner K | 2001 | Inorg Chem2001，40，： | 1 |
| 18 | ^226Ra bioavailability to plants at the Urgeirica uranium mill tailing site显示文摘 | Madruga M J Brogueira A Alberto G | 2001 | Journal of Environmental Radioactivity2001，54，： | 1 |
| 19 | 226Ra bioavailability to plants at the urgeirica uranium mill tailings site显示文摘 | Madrugaa M J Brogueiraa A Alberto G | | 0，，01： | 1 |
| 20 | Optimal coordination of directional overcurrent relays in interconnected power systems显示文摘 | Alberto J Urdaneta Ramon Nadira Luis G Perez Jimenez | 1988 | IEEE Transactions on Power Delivery1988，3，3： | 1 |
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