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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Transactions on Power Systems2004，19，1： | 1 |
| 3 | A newmethodology for the coordinated design of robustdecentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEETransactions on Power Systems2004，19，1： | 1 |
| 4 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 5 | Optimisation of medium composition for clavulanic acid production by Streptomyces clavuligerus显示文摘 | Ester R G Alvaro B N Alberto C B J | 2001 | Biotechnology Letters2001，23，： | 1 |
| 6 | Parenchymal abnormalities associated with developmental venous anomalies显示文摘 | Diego San Millán Ruíz Jacqueline Delavelle Hasan Yilmaz Philippe Gailloud Enrico Piovan Alberto Bertramello Francesca Pizzini Daniel A Rüfenacht | 2007 | Neuroradiology2007，，12： | 1 |
| 7 | A New Methodology for the Coordinated Design of Robust Decentralized Power System Damping Controllers 显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | Power Systemsd IEEE Transactions on2004，19，1： | 1 |
| 8 | Optimisation of me- dium composition for clavulanic acid production by Strep- tomyces clavuligerus 显示文摘 | Ester R G Alvaro B N Alberto C B J | 2001 | Biotechnology Letters2001，23，2： | 1 |
| 9 | A new methodology for the coordinated design of robust decentralized power system damping controllers显示文摘 | Ramos R A Alberto L F C Bretas N G | 2004 | IEEE Trans on Power Systems2004，19，1： | 1 |
| 10 | Optimisation of medimn composition for clavulanic acid production by streptomyoes clavuligems显示文摘 | Ester R G Alvaro B N Alberto C et ai | 2001 | Bioteehnology Letters2001，23，2： | 1 |
| 11 | Optimisation of Medium Composition for Clavulanic Acid Production by Streptomyces Clavuligerus显示文摘 | ESTER R G ALVARO B N ALBERTO C B J | 2001 | Biotechnology Letters2001，23，： | 1 |
| 12 | A method of the correlation dimension for on-line condition monitoring of large rotating machinery显示文摘 | Alberto R N Montesino Etero M E | 2005 | Mechanical System and Signal Processing2005，19，： | 1 |
| 13 | Updates on pathogen inactivation of plamsa using Theraflex methylene blue system显示文摘 | Julio del R'o-Garma Alberto Alvarez-Larra'n Clara Mart'nez | 2008 | British Journal of Haematology2008，38，3： | 1 |
| 14 | Optimisation of medium composition for clavulanic acid production by Streptomyces clavu-ligerus显示文摘 | Ester R G Alvaro B N Alberto C B J | | 0，，： | 1 |
| 15 | A method for the cor-relation dimension estimation for on-linecondition monitoring oflarge rotating machinery显示文摘 | ALBERTO R N MATIA-ELENA M O | 2005 | Mechanical Systems and SignalProcessing2005，19，： | 1 |
| 16 | Synthesis and properties of boranocarbonate : A convenient in situ CO source for the aqueous preparation of + 显示文摘 | Alberto R Ortner K Wheatley N | 2001 | Chem Soc Chem Commun2001，123，13： | 1 |
| 17 | CD40 -1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke显示文摘 | Alberto del Rí o-Espí nola Israel Ferná ndez-Cadenas Marta Rubiera Manuel Quintana Sophie Domingues-Montanari Maite Mendió roz Jessica Ferná ndez-Morales Dolors Giralt Carlos A Molina José á lvarez-Sabí n Joan Montaner | 2010 | Pharmacogenomics2010，，： | 1 |
| 18 | Synthesis and properties of boranocarbonate:A convenient in situ CO source for the aqueous preparation of+显示文摘 | Alberto R Ortner K Wheatley N | 2001 | Chem Soc Chem Commun2001，123，13： | 1 |
| 19 | Synthesis and properties of boranocarbonate: a convenient in situ CO source for the aqueous preparation of ^+ 显示文摘 | Alberto R Ortner K Wheatley N | 2001 | J Am Chem Soc2001，123，13： | 1 |
| 20 | A method for the correlation dimension estimation for on-line condition monitoring of large rotating machinery 显示文摘 | ALBERTO R N MARIA-ELENA M O | 2005 | Mechanical Systems and Signal Processing2005，19，5： | 1 |
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