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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | Stress concentrations in a viscoelastic composite plate weak- ened by a triangular hole显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
| 3 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 4 | Antibody profile, interferon-gamma and nutritional status in cryptosporidial infection among school children显示文摘 | Allam A F Abou-Shousha S A Abou Shamaa L A | 2002 | Egypt Soc Parasitol2002，32，3： | 1 |
| 5 | Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility 显示文摘 | BADAWY A SHOKEIR A ALLAM A F | 2009 | Acta Obstet Gynecol Scand2009，88，2： | 1 |
| 6 | Invasive pulmonary aspergillosis:retrospective case record review显示文摘 | ALLAM M F SERRANO D E L CASTILLO A DIAZ-MOLINA C | 2004 | Rev Iberoam Micol2004，21，1： | 1 |
| 7 | Synthesis of some new benzothiazole derivatives as potential antimicrobial and antiparasotic agents显示文摘 | Mahran M A El-nassry S M F Allam S R | 2003 | Pharmazie2003，58，8： | 1 |
| 8 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | ALLAM M N M ZENKOUR A M EL-MEKAWY H F | 2007 | Composite Structures2007，79，1： | 1 |
| 9 | Pneumatization of the temporal bone 显示文摘 | ALLAM A F | 1969 | Ann Otol Rhinol Laryngol1969，，3： | 1 |
| 10 | Islanding detection method for DFIG wind turbines using artificial neural networks 显示文摘 | ABD-ELKADER A G ALLAM D F TAGELDIN E | 2014 | International Journal of Electrical Power & Energy Systems2014，，62： | 1 |
| 11 | Enhanced photoassisted water electrolysis using vertically oriented anodically fabricated Ti-Nb-Zr-O mixed oxide nanotube arrays显示文摘 | Allam N K Alamgir F EI-Sayed M A | 2010 | ACS Nano2010，4，10： | 1 |
| 12 | Synthesis of some new benzothiazole derivatives as potential antimicrobial and antiparasitic agents显示文摘 | Mahran M A Elnassry S M F Allam S R | 2003 | Pharmazie2003，58，8： | 1 |
| 13 | Application of FTIR Spec- troscopy in the Determination of Antioxidant Effi- ciency in Sunflower Oil显示文摘 | Hamed S F Allam M A | 2006 | Journal of Applied Sci- ences Research2006，2，1： | 1 |
| 14 | Evaluation of PCR As- say for Detection of Cow's Milk in Water Buffalo's Milk 显示文摘 | DARWISH S F ALLAM H A AMIN A S | 2009 | World Applied Sciences Journal2009，7，4： | 1 |
| 15 | Synthesis of some new benzothiazole derivatives as potential antimicrobial and antiparasitic agents显示文摘 | Mahran M A El-nassry S M F Allam S R | 2003 | Pharmazie2003，58，8： | 1 |
| 16 | Stress concentrations in a viscoelastic composite plate weakened by a triangular hole 显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
| 17 | Stess concentrations in a viscoelastic composite plate weakened by a triangular hole显示文摘 | Allam M N M Zenkour A M El-Mekawy H F | 2007 | Composite Structures2007，79，1： | 1 |
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