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| 1 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 2 | First experience and preliminary clinical reults with the cervical disc replacement discover显示文摘 | Greiner-Perth R Allam Y Silbermarm J | 2009 | Z Orthop Unfall2009，147，5： | 1 |
| 3 | A new technique for the treatment of lumbar far lateral disc herniation:technical note and preliminary results显示文摘 | Greiner PR Bohm H Allam Y | 2003 | Eur Spine J2003，12，3： | 1 |
| 4 | Reoperation rate after instrumented posterior lumbar interbody fusion: a report on 1680 cases显示文摘 | Greiner-Perth R Boehm H Allam Y | 2004 | Spine2004，29，22： | 1 |
| 5 | Analysis of reoperations after surgical treatment of degenerative cervical spine disorders:a report on 900 cases显示文摘 | Greiner-Perth R Allam Y Ei-Saghir H | | 0，，01： | 1 |
| 6 | Ewing's sarcoma of the head and neck: a retrospective analysis of 24 cases显示文摘 | Allam A E1-Husseiny G Khafaga Y | 1999 | Sarcoma1999，3，1： | 1 |
| 7 | Analysis of reoperations after surgical treatment of degenerative cervical spine disorders:a report on 900 cases显示文摘 | Greiner-Perth R Allam Y E1-Saghir H | | 0，，01： | 1 |
| 8 | Neoadjuvant chemotherapy plus conventional radiotherapy or accelerated hyperfractionation in stage Ⅲ and Ⅳ nasopharyngeal carcinoma-a phase Ⅱ study显示文摘 | El-Weshi A Khafaga Y Allam A | 2001 | Acta Oncol2001，40，5： | 1 |
| 9 | Neoadjuvant chemotherapy plus conventional radiotherapy or accelerated hyperfractionation in stage III and IV nasopharyngeal carcinoma - a phase II study显示文摘 | EL-WESHI A KHAFAGA Y ALLAM A | 2001 | Acta Oncol2001，40，5： | 1 |
| 10 | Computer tomography assess- ment of pedicle screw placement in lumbar and sacral spine: compar- ison between free-hand and O-ann based navigation techniques显示文摘 | Silbermann J Riese F Allam Y | 2011 | Eur Spine J2011，20，： | 1 |
| 11 | First experience and preliminary dinical results with the cervical disc replacement Discover显示文摘 | Greiner-Perth R Allam Y Silbermann J | 2009 | Z Orthop Urrfall2009，147，5： | 1 |
| 12 | Ewing's sarcoma of the head and neck: a retro- spective analysis of 24 cases显示文摘 | ALLAM A EL-HUSSEINY G KHAFAGA Y | 1999 | Sarcoma1999，3，： | 1 |
| 13 | IL-23-producing CD68+macrophage-like cells predominate within an IL-17-polarized infiltrate in chronic periodontitis lesions显示文摘 | Allam JP Duan Y Heinemann F | 2011 | J Clin Periodontol2011，38，10： | 1 |
| 14 | A new technique for the treatment of lumbar far lateral disc herniation:technical note and preliminary results显示文摘 | Greiner-Perth R Bohm H Allam Y | 2003 | Eur Spine J2003，12，3： | 1 |
| 15 | Reoperation rate after instrumented posterior lumbar interbody fusion:a report on 1680 cases显示文摘 | Greiner-Perth R Boehm H Allam Y | 2004 | Spine2004，29，22： | 1 |
| 16 | Neoadjuvant chemotherapy plus conventional radiotherapy or accelerated hyperfractionation in stage Ⅲ and Ⅳ nasopharyngeal carcinoma--a phase Ⅱ study显示文摘 | El-Weshi A Khafaga Y Allam A | | 0，，： | 1 |
| 17 | Reoperation rate after instrumented posterior lumbar interbody fusion:a report on 168 cases显示文摘 | Greiner-Perth R Boehm H Allam Y | 2004 | Spine2004，29，22： | 1 |
| 18 | Comparison between Oxford Cobbmeter and digital Cobbmeter for measurement of Cobb angle in adolescent idiopathic scoliosis 显示文摘 | ALLAM Y EL-FIKY T FARGHALLY MY | 2016 | Eur Spine J2016，25，2： | 1 |
| 19 | Reoperation rate after instrumented posterior lumbar interbody fusion:a report on 1680 cases显示文摘 | Greiner-Perth R Boehm H Allam Y | 2004 | Spine2004，29，22： | 1 |
| 20 | Micro-perforated plates for vehicle applications显示文摘 | Guo Y Allam S Abom M | 2008 | Mwl Flow Acoustics2008，，： | 1 |
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