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| 1 | Computed tomography-guided percutaneous core needle biopsy in pancreatic tumor diagnosis显示文摘AIM: To evaluate the techniques, results, and complications related to computed tomography(CT)-guided percutaneous core needle biopsies of solid pancreatic lesions.METHODS: CT-guided percutaneous biopsies of solid pancreatic lesions performed at a cancer reference center between January 2012 and September 2013 were retrospectively analyzed. Biopsy material was collected with a 16-20 G Tru-Core needle(10-15 cm; Angiotech, Vancouver, CA) using a coaxial system and automatic biopsy gun. When direct access to the lesion was not possible, indirect(transgastric or transhepatic) access or hydrodissection and/or pneumodissection maneuvers were used. Characteristics of the patients, lesions, procedures, and histologic results were recorded using a standardized form. RESULTS: A total of 103 procedures included in the study were performed on patients with a mean age of 64.8 year(range: 39-94 year). The mean size of the pancreatic lesions was 45.5 mm(range: 15-195 mm). Most(75/103, 72.8%) procedures were performed via direct access, though hydrodissection and/or pneumodissection were used in 22.2%(23/103) of cases and indirect transhepatic or transgastric access was used in 4.8%(5/103) of cases. Histologic analysis was performed on all biopsies, and diagnoses were conclusive in 98.1%(101/103) of cases, confirming3.9%(4/103) of tumors were benign and 94.2%(97/103) were malignant; results were atypical in 1.9%(2/103) of cases, requiring a repeat biopsy to diagnose a neuroendocrine tumor, and surgical resection to confirm a primary adenocarcinoma. Only mild/moderate complications were observed in 9/103 patients(8.7%),and they were more commonly associated with biopsies of lesions located in the head/uncinate process(n =8), than of those located in the body/tail(n = 1) of the pancreas, but this difference was not significant.CONCLUSION: CT-guided biopsy of a pancreatic lesion is a safe procedure with a high success rate, and is an excellent option for minimally invasive diagnosis. | Chiang J Tyng Maria Fernanda A Almeida Paula NV Barbosa Almir GV Bitencourt José Augusto AG Berg Macello S Maciel Felipe JF Coimbra Luiz Henrique O Schiavon Maria Dirlei Begnami Marcos D Guimares Charles E Zurstrassen Rubens Chojniak | 2015 | World Journal of Gastroenterology2015，21，12： | 14 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Angiotensin-(1 7): cardioprolective effect in myocardial ischemia/reperfusion 显示文摘 | FERREIRA A J SANLOS R A ALMEIDA A P | 2001 | Hypertension2001，38，： | 1 |
| 4 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 5 | Preparation of conducting polyanilines doped with Keggin - type polyoxometalates and their application as counter electrode in dye - sensitized solar cells显示文摘 | ALMEIDA L GONCALVES A BENEDETTI J MIRANDA P PASSONI L NOGUEIRA A | 2010 | J Mater Sci2010，45，18： | 1 |
| 6 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 7 | Oc- currence of Cryptosporidium parvum and Giardia duodenalis in healthy adult domestic ruminants 显示文摘 | Castro-Hermida J A Almeida A Gonzlez-Warleta M | 2007 | earasitol Res2007，101，5： | 1 |
| 8 | Participation of doubly fed induction wind generators in system frequency regulation显示文摘 | DE ALMEIDA R G LOPES J A P | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 9 | Participation of Doubly Fed Induction Wind Generations in System Frequency Regulation 显示文摘 | ALMEIDA R G LOPES J A | 2007 | IEEE Transactions on Power System2007，22，3： | 1 |
| 10 | Ultrasound-assisted single-drop microextraction for the determination of cadmium in vegetable oils using high-resolution continuum source electrothermal atomic absorption spectrometry显示文摘 | ALMEIDA J S ANUNCIACAO T A BRANDAO G C | 2015 | Spectrochimica Acta Part B: Atomic Spectroscopy2015，107，： | 1 |
| 11 | Micro- and nano-crystalline CVD diamond coated tools in the turning of EI)M graphite 显示文摘 | ALMEIDA F A SACRAMENTO J OLIVEIRA F J | 2008 | Surface and Coatings Technology2008，203，： | 1 |
| 12 | Study of the quality of life in people with traumatic spinal cord injury显示文摘 | VALL J BRAGA V A DE ALMEIDA P C | 2006 | Arquivos de Neuro-Psiquiatria2006，64，2： | 1 |
| 13 | Angiotensin-(1 - 7 ) : cardioprotective effect in myocardial ischemic/reperfusion显示文摘 | FERREIRA A J SANTOS R A ALMEIDA A P | 2001 | Hypertension2001，38，3： | 1 |
| 14 | Mito-chondrial respiratory chain and free radical generationin stroke 显示文摘 | Moro M A Almeida A Bola os J P Lizasoain I | 2005 | Free Radic Biol Med2005，39，： | 1 |
| 15 | Integrationof electric vehicles in the electric power system显示文摘 | Lopes J A P Soares F J Almeida P M R | 2011 | Proceedings of the IEEE2011，99，1： | 1 |
| 16 | Optimum generation control in wind park when carry out system operator request显示文摘 | R G de Almeida E D Castonuovo J A Pecas Lopes | | 0，，02： | 1 |
| 17 | Physical Characterization and Compression Tests of One Leaf Stone Masonry Walls 显示文摘 | Almeida C Guedes J P Ar~de A | 2012 | Construction and Building Materials2012，30，： | 1 |
| 18 | Studyofmolecular epidemiology of candidiasis in Portugal by PCR fingerprinting of Candida clinical isolates显示文摘 | Correia A Sampalo P Almeida J | 2004 | Clin Microbiol2004，42，12： | 1 |
| 19 | Summary cache: a scalable wide-area Web cache sharing protocol显示文摘 | FAN L CAO P ALMEIDA J BRODER A Z | 2000 | IEEE-ACM Trans on Networking2000，8，3： | 1 |
| 20 | Oxi-dative stress biomarkers in the freshwater characidfish,Brycon cephalus,exposed to organophosphorusinsecticide Folisuper 600(methyl parathion)显示文摘 | Monteiro D A Almeida J A Rantin FT | 2006 | Comparative Biochemistry and Physiology Part C2006，143，2： | 1 |
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