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| 1 | Small artery structure and hypertension: adaptive changes and target organ damage显示文摘 | Ashley S Izzard Damiano Rizzoni Enrico Agabiti-Rosei Anthony M Heagerty | 2005 | Journal of Hypertension2005，，2： | 5 |
| 2 | Awake Systolic Blood Pressure Variability Correlates With Target-Organ Damage in Hypertensive Subjects显示文摘 | Alfonso Tatasciore Giulia Renda Marco Zimarino Manola Soccio Grzegorz Bilo Gianfranco Parati Giuseppe Schillaci Raffaele De Caterina | 2007 | Hypertension2007，，2： | 3 |
| 3 | Oxidative stress-mediated effects of angiotensin Ⅱ in the cardiovascular system显示文摘Angiotensin Ⅱ(Ang Ⅱ), an endogenous peptide hormone, plays critical roles in the pathophysiological modulation of cardiovascular functions. Ang Ⅱ is the principle effector of the renin-angiotensin system for maintaining homeostasis in the cardiovascular system, as well as a potent stimulator of NAD(P)H oxidase, which is the major source and primary trigger for reactive oxygen species(ROS) generation in various tissues. Recent accumulating evidence has demonstrated the importance of oxidative stress in Ang Ⅱ-induced heart diseases. Here, we review the recent progress in the study on oxidative stress-mediated effects of Ang Ⅱ in the cardiovascular system. In particular, the involvement of Ang Ⅱ-induced ROS generation in arrhythmias, cell death/heart failure, ischemia/reperfusion injury, cardiac hypertrophy and hypertension are discussed. Ca2+/calmodulin-dependent protein kinase Ⅱ is an important molecule linking Ang Ⅱ, ROS and cardiovascular pathological conditions. | Hairuo Wen Judith K Gwathmey Lai-Hua Xie | 2012 | World Journal of Hypertension2012，2，4： | 3 |
| 4 | Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study显示文摘 | Eamon Dolan Lutgarde Thijs Yan Li Neil Atkins Patricia McCormack Sean McClory Eoin O’Brien Jan A. Staessen Alice V. Stanton | 2006 | Hypertension2006，，3： | 3 |
| 5 | Mechanisms for Inducible Control of Angiotensinogen Gene Transcription显示文摘 | Allan R. Brasier Junyi Li | 1996 | Hypertension1996，，3： | 3 |
| 6 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 7 | Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role显示文摘 | Senthil Kumar Venugopal Sridevi Devaraj Ishwarlal Jialal | 2005 | Current Opinion in Nephrology and Hypertension2005，，1： | 3 |
| 8 | Dominant negative mutant of c-Jun inhibits cardiomyocyte hypertrophy induced by endothelin 1 and phenylephrine显示文摘 | Omura T Yoshiyama M Yoshida K | 2002 | Hypertension2002，39，1： | 3 |
| 9 | Prognostic Value of Serum LP-PLA2 and hs-CRP in Unstable Atherosclerotic Plaques显示文摘 | Yimeng Du Fengtao Wei Zhaoqiang Dong Junni Liu Weidong Jiang Qinghua Lu | 2011 | Clinical and Experimental Hypertension2011，，2： | 3 |
| 10 | Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations显示文摘 | Roland Asmar Annie Rudnichi Jacques Blacher Gérard M London Michel E Safar | 2001 | American Journal of Hypertension2001，，2： | 3 |
| 11 | Outcomes of middle cerebral artery occlusion in hypertensive and normotensive rats显示文摘 | Coyle P | 1984 | Hypertension1984，6，2： | 2 |
| 12 | Relationship between splanchnic vasodilation and postprandial hypotension in patients with primary autonomic failure显示文摘 | Jaspal S. Kooner Sarah Raimbach Laura Watson Roger Bannister Stanley Peart Christopher J. Mathias | 1989 | Journal of Hypertension1989，，： | 2 |
| 13 | Cerebral circulation in chronic arterial hypertension显示文摘 | Baumbach GL Heistad DD | 1988 | Hypertension1988，12，2： | 2 |
| 14 | Reduced levels of N-terminal-proatrial natriuretic peptide in hypertensive patients with metabolic syndrome and their relationship with left ventricular mass显示文摘 | Speranza Rubattu Sebastiano Sciarretta Giuseppino Massimo Ciavarella Vanessa Venturelli Paola De Paolis Giuliano Tocci Luciano De Biase Andrea Ferrucci Massimo Volpe | 2007 | Journal of Hypertension2007，，4： | 2 |
| 15 | Hyperuricemia and Incidence of Hypertension Among Men Without Metabolic Syndrome显示文摘 | Eswar Krishnan C Kent Kwoh H Ralph Schumacher Lewis Kuller | 2007 | Hypertension2007，，2： | 2 |
| 16 | Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats 显示文摘 | Huang BS Leenen FHH | 1999 | hypertension1999，34，1： | 2 |
| 17 | Role of oxidative stress in cardiovascular diseases显示文摘 | Naranjan S. Dhalla Rana M. Temsah Thomas Netticadan | 2000 | Journal of Hypertension2000，，6： | 2 |
| 18 | The Beneficial Effect of Regular Endurance Exercise Training on Blood Pressure and Quality of Life in Patients with Hypertension显示文摘 | Jen‐Chen Tsai Hung‐Yu Yang Wei‐Hsin Wang Ming‐Hsiung Hsieh Pei‐Ti Chen Ching‐Chiu Kao Pai‐Feng Kao Chia‐Hui Wang Paul Chan | 2004 | Clinical and Experimental Hypertension2004，，3： | 2 |
| 19 | The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke显示文摘 | Christa Th?ne-Reineke Christian Neumann Pawel Namsolleck Kristin Schmerbach Maxim Krikov Jan H Schefe Kristin Lucht Heide H?rtnagl Michael Godes Susanne Müller Kay Rumschüssel Heiko Funke-Kaiser Arno Villringer U Muscha Steckelings Thomas Unger | 2008 | Journal of Hypertension2008，，12： | 2 |
| 20 | Hypertension induced by chronic renal adrenergic stimulation is angiotensin dependent 显示文摘 | Reinhart AG Lohmeier TE Hord CE | 1995 | Hypertension1995，25，5： | 2 |
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