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| 1 | Immunoexpression of cyclooxygenase-2 in primary gastric carcinomas and lymph node metastases显示文摘AIM: To evaluate immunoexpression of cyclooxygenase-2 (COX-2) in primary gastric carcinomas and respective lymph node metastases. METHODS: Immunohistochemistry to analyze COX-2 expression was performed on tissue microarray slices obtained from 36 specimens of gastrectomy and satellite lymph nodes from patients with gastric carcinoma. RESULTS: Immunostaining was seen in most cases, and COX-2 expression was higher in lymph node me-tastases than in corresponding primary gastric tumors of intestinal, diffuse and mixed carcinomas, with a statistically signif icant difference in the diffuse histotype (P = 0.0108). CONCLUSION: COX-2 immunoexpression occurs frequently in primary gastric carcinomas, but higher expression of this enzyme is observed in lymph node metastases of the diffuse histotype. | Paulo RC Almeida Francisco VA Ferreira Cássio C Santos Francisco D Rocha-Filho Raul RP Feitosa Esther AA Falco Belise K Cavada Roberto CP Lima-Júnior Ronaldo A Ribeiro | 2012 | World Journal of Gastroenterology2012，18，8： | 14 |
| 2 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 3 | Purification of metallurgical grade silicon by acid leaching显示文摘 | SANTOS I C GONCALVES A P SANTOS C S ALMEIDA M AFONSO M H CRUZ M J | 1990 | Hydrometallurgy1990，23，： | 1 |
| 4 | Improving hierarchical cluster analysis: a new method with outlier detection and automatic clustering显示文摘 | ALMEIDA J A S BARBOSA L M S PAIS A A C C | 2007 | Chemometrics and Intelligent Labora- tory Systems2007，87，2： | 1 |
| 5 | Near-surface circulation and kinetic energy in the tropical Indian Ocean derived from Lagrangian drifters显示文摘 | SHENOI S S C SAJI P K ALMEIDA A M | 1999 | Journal of Marine Research1999，57，6： | 1 |
| 6 | Ultrasound-assisted single-drop microextraction for the determination of cadmium in vegetable oils using high-resolution continuum source electrothermal atomic absorption spectrometry显示文摘 | ALMEIDA J S ANUNCIACAO T A BRANDAO G C | 2015 | Spectrochimica Acta Part B: Atomic Spectroscopy2015，107，： | 1 |
| 7 | Transcriptional regulation of the murine Connexin40 promoter by cardiac factors Nkx2-5,GATA4 and Tbx5显示文摘 | Linhares V L Almeida N A Menezes D C | 2004 | Cardiovasc Res2004，64，3： | 1 |
| 8 | Determination of chemical ox- ygen demand employed manganese as an environmentally friendly oxidizing reagent by a flow injection method based on microwave digestion and speeiation coupled to ICP -OES 显示文摘 | Almeida C A Savio M Gonzdlez P | 2013 | M ieroehemieal Journal: Devoted to the Application of Mieroteehniques in all Branches of Science2013，106，10： | 1 |
| 9 | Estrogen receptor-[alpha] signaling in osteoblast progenitors stimulates cortical bone accrual显示文摘 | Almeida Maria Iyer Srividhya Martin-Millan Marta Bartell Shoshana M Han Li Ambrogini Elena Onal Melda Xiong Jinhu Weinstein Robert S Jilka Robert L O’Brien Charles A Manolagas Stavros C | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 10 | Biochemi- cal response in farmed mussel Perna perna transplanted to con- taminated sites on Santa Catarina Island, SC, Brazeil 显示文摘 | BAINY A C D ALMEIDA E A MULLER I C | 2000 | Ma- rine Environmental Research2000，50，12345： | 1 |
| 11 | Study of the quality of life in people with traumatic spinal cord injury显示文摘 | VALL J BRAGA V A DE ALMEIDA P C | 2006 | Arquivos de Neuro-Psiquiatria2006，64，2： | 1 |
| 12 | Study on high performance roller compacted concrete显示文摘 | BETTENCOURT RIBEIRO A C DE ALMEIDA I R | 2000 | Materials and Structures2000，33，6： | 1 |
| 13 | Effect of soil moisture and fertilization on Perola pineapple in Coastal Tableland areas of Brazil 显示文摘 | Souza L F D de Almeida O A Caldas R C | 2002 | Tropical Agriculture2002，79，2： | 1 |
| 14 | Source apportionment of fine and coarse particulate matter in a suburban area at the Western European Coast 显示文摘 | Almeida S M PioC A Freitas M C | 2005 | Atmospheric Environment2005，39，17： | 1 |
| 15 | Physical Characterization and Compression Tests of One Leaf Stone Masonry Walls 显示文摘 | Almeida C Guedes J P Ar~de A | 2012 | Construction and Building Materials2012，30，： | 1 |
| 16 | From micro to Nano-crystalline transition in the diamond formation on porous Pure titanium显示文摘 | Braga N A Cairo C A A Almeida E C | 2008 | Diam Relat Mater2008，17，： | 1 |
| 17 | Stochastic Cellular Automata Modeling of Urban Land Use Dynamics: Empirical Development and Estimation 显示文摘 | Almeida C M Batty M Monteiro A M V | 2003 | Computers Environment and Urban Systems2003，27，5： | 1 |
| 18 | Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice显示文摘 | Weinstein R S O'Brien C A Almeida M | 2011 | Endocrinology2011，152，9： | 1 |
| 19 | Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality显示文摘 | Almeida C Cardoso MF Sousa M Viana P Gon(c)alves A Silva J | 2005 | Hum Reprod2005，20，5： | 1 |
| 20 | Genetic diversity of a Brazilian Creole cattle based on fourteen microsatellite loci显示文摘 | Steigleder C S Almeida E A Weimer T A | 2004 | Arch Zootec2004，53，： | 1 |
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