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| 1 | Mesenchymal stem cell therapy in patients with small bowel transplantation:Single center experience显示文摘AIM:To study the effects of mesenchymal stem cell(MSC) therapy on the prevention of acute rejection and graft vs host disease following small bowel transplantation.METHODS: In our transplantation center, 6 isolated intestinal transplants have been performed with MSC therapy since 2009. The primary reasons for transplants were short gut syndrome caused by surgical intestine resection for superior mesenteric artery thrombosis(n = 4), Crohn's disease(n = 1) and intestinal aganglionosis(n = 1). Two of the patients were children. At the time of reperfusion, the first dose of MSCs cultured from the patient's bone marrow was passedinto the transplanted intestinal artery at a dose of 1000000 cells/kg. The second and third doses of MSCs were given directly into the mesenteric artery through the arterial anastomosis using an angiography catheter on day 15 and 30 post-transplant.RESULTS: The median follow-up for these patients was 10.6 mo(min: 2 mo-max: 30 mo). Three of the patients developed severe acute rejection. One of these patients did not respond to bolus steroid therapy. Although the other two patients did respond to antirejection treatment, they developed severe fungal and bacterial infections. All of these patients died in the 2nd and 3rd months post-transplant due to sepsis. The remaining patients who did not have acute rejection had good quality of life with no complications observed during the follow-up period. In addition, their intestinal grafts were functioning properly in the 13th, 25th and 30th month post-transplant. The patients who survived did not encounter any problems related to MSC transplantation.CONCLUSION: Although this is a small case series and not a randomized study, it is our opinion that small bowel transplantation is an effective treatment for intestinal failure, and MSC therapy may help to prevent acute rejection and graft vs host disease following intestinal transplantation. | Sait Murat Do?an Sel?uk K?l?n? Eyüp Kebap?? Cem Tu?men Mustafa ?lmez Cezmi Karaca Alp Gürkan Ma?allah Baran Yusuf Kurtulmu? | 2014 | World Journal of Gastroenterology2014，20，25： | 3 |
| 2 | An incremental genetic algorithm for classification and sensitivity analysis of its parameters显示文摘 | GOZDE B DERYA B ALP K | 2011 | System with Appli- cation2011，38，3： | 1 |
| 3 | Fluorescence emission studies of 4-(2-furylmethylene)-2-phenyl -5-oxazolone embedded in polymer thin film and detection of Fe^3+ ion 显示文摘 | Ozturk G Alp S Ertekin K | 2007 | Dyes and Pigments2007，72，2： | 1 |
| 4 | Risk factors for nosoco-mial infection and mortality in bum patients: 10 years ofexperience at a university hospital 显示文摘 | Alp E Coruh A Gunay G K | 2012 | Journal of BumCare & Research2012，33，3： | 1 |
| 5 | Comparison of organic solvents used for the determination of mustard gas hydrolysis products in urine samples using gas chromatography-mass spectrometry 显示文摘 | Levent K Orkun Alp | 2004 | Rapid Commun Mass Spectrom2004，18，： | 1 |
| 6 | Utility of a commercial quantitative hepatitis C virus core antigen assay in a diagnostic laboratory setting显示文摘 | Ergunay K Sener B Alp A | 2011 | Diaqn Microbiology Infect Dis2011，70，4： | 1 |
| 7 | Outsourcing logistics:designing transportation contracts between a manufacturer and a transporter显示文摘 | ALP O ERKIP N K GULLU R | 2003 | Transportation Sci2003，37，1： | 1 |
| 8 | Generalized Regression Neural Network in Modelling River Sediment Yield 显示文摘 | CIGIZOGLU H K ALP M | 2006 | Advances in Engineering Software2006，37，2： | 1 |
| 9 | Effects of Dietary Supplementation with Organic Acids and Zinc Bacitracin on Ileal Microflora, pH and Performance in Broilers显示文摘 | ALP M M KOCABAGLI R KAHRAMAN K | 1999 | J of Veterinary and Animal Sciences1999，23，： | 1 |
| 10 | Outsourcing logistics:De- signing transportation contracts between a manufacturer and a trans- porter显示文摘 | Osman Alp Nesim K Erkip9Refik G ii 11 ii | 2003 | Transportation Science2003，37，1： | 1 |
| 11 | Doxycycline plus streptomycin versus ciprofloxacin plus rifampicin in spinal brucellosis 显示文摘 | ALP E KOC R K DURAK A C | 2006 | BMC Infect Dis2006，6，1： | 1 |
| 12 | Generalized regression neural network in modelling river sediment yield显示文摘 | Cigizoglu H K Alp M | 2006 | Advances in Engineering Software2006，37，2： | 1 |
| 13 | Mechanical and microstructural characterization of 6061 aluminum alloy strips severely deformed by dissimilar channel angular pressing 显示文摘 | Evren T Alp A K Hakan C G | 2011 | Materials Characterization2011，62，： | 1 |
| 14 | Utility of a commercial quan- titative hepatitis C virus core antigen assay in a diagnostic laboratory setting显示文摘 | Ergunay K Sener B Alp A e t a/ | 2011 | Diagn Mierobiol Infect Dis2011，70，4： | 1 |
| 15 | Outsourcing Logistics: Designing Transportation Contracts between a Manufacturer and a Transporter 显示文摘 | Osman Alp Nesim K Erkip Re k Gullu | 2003 | Transportation Science2003，37，1： | 1 |
| 16 | Outsourcing logistics: Designing transportation contracts between a manufacturer and a transporter显示文摘 | Alp O Erkip N K Gullu R | 2003 | Transportation Science2003，37，1： | 1 |
| 17 | Outsourcing logistics: designing transportation contracts between a manufacturer and a trans- porter 显示文摘 | Alp O Erkip N K G 11 R | | Transportation Science0，37，1： | 1 |
| 18 | Toxicity evalu- ation and source apportionment of polycyclic aromatic hydrocarbons (PAHs) at three stations in Istanbul, Turkey显示文摘 | Hanedar A Alp K Kaynak B | 2014 | SciTotal Environ2014，，： | 1 |
| 19 | Toxicity evaluation and source apportionment of polycyclic aromatic hydrocarbons(PAHs)at three stations in Istanbul,Turkey显示文摘 | Hanedar A Alp K Kaynak B | 2014 | Science of the Total Environment2014，，： | 1 |
| 20 | Outsourcing logistics: Designing transportation contracts between a manufacturer and a transporter显示文摘 | Alp O Erkip N K Gullu R | 2003 | Transportation Science2003，37，1： | 1 |
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