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7篇 您的检索式：作者名="ALUN B"

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		题名	作者	年代	出处	被引量
	1	Large-scale dispersant leaching and effectiveness ex- periments with oils on calm water 显示文摘	Alun Lewis A B Ken Trudel Randy C Belore	2010	Marine Pollution Bulletin2010，60，2：	1
	2	Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incident coronary heart disease: the PRIME study显示文摘	GERALD LUC A B DOMINIQUE ARVEIER C ALUN EVANS D	2003	Atherosclerosis2003，170，1：	1
	3	Large-scale dispersant leaching and effectivenessexperiments with oils on calm water 显示文摘	LEWIS ALUN KEN TRUDEL B BEL0RE RANDY C	2010	Marine Pollu-tion Bulletin2010，60，：	1
	4	Circulating soluble adhesion molecules ICAM-1 and VCAM-1 and incient coronary heart disease:the PRIME study显示文摘	Gerald LUC A B Dominique Arveier C Alun Evans D	2003	Atherosclerosis2003，170，1：	1
	5	A System for the Dynamic Characterization of Microstructures 显示文摘	James S B Alun J H David W	1997	Journal of Microelectromechanical Systems1997，6，4：	1
	6	Stability of aqueous α-Al2O3 suspensions withpoly(methacrylic acid) polyelectrolyte 显示文摘	JOSEPH C ILHAN A A ALUN B	1988	Am Ceram Soc1988，71，4：	1
	7	Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes显示文摘Acute myeloid leukaemia(AML)patients harbouring certain chromosome abnormalities have particularly adverse prognosis.For these patients,targeted therapies have not yet made a significant clinical impact.To understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres(in UK and Finland)at the proteomic,phosphoproteomic and drug response phenotypic levels.These data were complemented with transcriptomics analysis for 39 cases.Data integration highlighted a phosphoproteomics signature that define two biologically distinct groups of KMT2A rearranged leukaemia,which we term MLLGA and MLLGB.MLLGA presented increased DOT1L phosphorylation,HOXA gene expression,CDK1 activity and phosphorylation of proteins involved in RNA metabolism,replication and DNA damage when compared to MLLGB and no KMT2A rearranged samples.MLLGA was particularly sensitive to 15 compounds including genotoxic drugs and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrogenase(IMPDH)relative to other cases.Intermediate-risk KMT2A-MLLT3 cases were mainly represented in a third group closer to MLLGA than to MLLGB.The expression of IMPDH2 and multiple nucleolar proteins was higher in MLLGA and correlated with the response to IMPDH inhibition in KMT2A rearranged leukaemia,suggesting a role of the nucleolar activity in sensitivity to treatment.In summary,our multilayer molecular profiling of AML with poor prognosis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics signature that defines two biologically and phenotypically distinct groups of KMT2A rearranged leukaemia.These data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLGA phosphoproteomics signature identified in this study.	Pedro Casado Ana Rio-Machin Juho JMiettinen Findlay Bewicke-Copley Kevin Rouault-Pierre Szilvia Krizsan Alun Parsons Vinothini Rajeeve Farideh Miraki-Moud David CTaussig Csaba Bödör John Gribben Caroline Heckman Jude Fitzgibbon Pedro R.Cutillas	2023	Signal Transduction and Targeted Therapy2023，8，3：	0

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