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| 1 | Therapeutic drug monitoring in patients with inflammatory bowel disease显示文摘Thiopurine analogs and anti-tumor necrosis factor(TNF)agents have dramatically changed the therapeutics of inflammatory bowel diseases(IBD),improving short and long-term outcomes.Unfortunately some patients do not respond to therapy and others lose response over time.The pharmacokinetic properties of these drugs are complex,with high inter-patient variability.Thiopurine analogs are metabolized through a series of pathways,which vary according to the patients’pharmacogenetic profile.This profile largely determines the ratios of metabolites,which are in turn associated with likelihoods of clinical efficacy and/or toxicity.Understanding these mechanisms allows for manipulation of drug dose,aiming to reduce the development of toxicity while improving the efficacy of treatment.The efficacy of anti-TNF drugs is influenced by many pharmacodynamic variables.Several factors may alter drug clearance,including the concomitant use of immunomodulators(thiopurine analogs and methotrexate),systemic inflammation,the presence of anti-drug antibodies,and body mass.The treatment of IBD has evolved with the understanding of the pharmacologic profiles of immunomodulating and TNF-inhibiting medications,with good evidence for improvement in patient outcomesobserved when measuring metabolic pathway indices.The role of routine measurement of metabolite/drug levels and antibodies warrants further prospective studies as we enter the era of personalized IBD care. | Andres J Yarur Maria T Abreu Amar R Deshpande David H Kerman Daniel A Sussman | 2014 | World Journal of Gastroenterology2014，20，13： | 2 |
| 2 | Older age is the strongest predictor of postoperative atrial fibrillation 显示文摘 | Amar D Zhang H Leung DH et ai | 2002 | Anesthesiology2002，96，2： | 1 |
| 3 | Scaling behaviour in the growth of companies显示文摘 | Stanley M H R Amaral L A N Buldyrev S V Havlin S Leschhorn H Maass P Salinger M A Stanley H E | 1996 | Nature1996，379，： | 1 |
| 4 | Ultrasound assisted microwave digestion 显示文摘 | CHEMAT S LAGHA A AMAR H A | 2004 | Ultrasonics Sonochemistry2004，11，： | 1 |
| 5 | A model for the growth dynamics of economic organizations显示文摘 | Amaral L A N Gopikrishnan P Plerou V Stanley H E | 2001 | Physica A2001，299，： | 1 |
| 6 | Resveratrol attenuates cisplatin-induced nephrotoxicity in rats显示文摘 | do AMARAL C L FRANCESCATO H D C COIMBRA T M | 2008 | Archives of Toxicology2008，82，6： | 1 |
| 7 | Econophysics:can physicists contribute to the science of economics显示文摘 | Stanley H E Amaral L A N Canning D | 1999 | Physica A1999，269，1： | 1 |
| 8 | 显示文摘 | Strathmann H Kock K Amar P | 1975 | Desalina tion1975，16，2： | 1 |
| 9 | The incidence and outcome of ventricular arrhythmias after noncardiac thoracic surgery显示文摘 | Amar D Zhang H Roistacher N | 2002 | Anesth Analg2002，95，3： | 1 |
| 10 | Formation mechanism of asymmetric membranes显示文摘 | Strathmann H Kock K Amar P Baker R W | 1975 | Desalination1975，16，2： | 1 |
| 11 | Fluorescence in situ hybridization:a highly efficient technique of molecular diagnosis and predication for disease course in patients with myeloid leukemias显示文摘 | AMARE P S BAISANE C SAIKIA T NAIR R GAWADE H ADVANI S | 2001 | Cancer Genet Cytogenet2001，131，2： | 1 |
| 12 | The incidence and outcome of ven- tficular arrhythmias after noncardiae thoracic surgery 显示文摘 | Amar D Zhang H Roistacher N | 2002 | Anesth Analg2002，95，3： | 1 |
| 13 | QTL for phytosterol and sinapate ester content in Brassica napus L,collocate with the two etude acid genes显示文摘 | AMAR S ECKE W B Becker H C | 2008 | Theor Appl Genet2008，116，： | 1 |
| 14 | Novel alka-line protease from Alkaliphilic bacteria grown onchicken feathcr显示文摘 | Amare G Rajni H K Berhanu A G | 2003 | Enzyme and Microbial Technolo-gy2003，32，： | 1 |
| 15 | Batch sorption dynamics and equilibrium for the removal of lead ions from aqueous phase u- sing activated carbon developed from coffee resi- due activated with zinc chloride 显示文摘 | Boudrahem F Aissani - Benissad F Ait - Amar H | 2009 | Journal of Environmental Management2009，90，10： | 1 |
| 16 | Several common variants modulate heart rate,PR interval and QRS duration显示文摘 | Holm H Gudbjartsson D F Amar D O | 2010 | Nature Genetics2010，42，2： | 1 |
| 17 | Ascending aorta dissecting aneurysm in a teenager with isolated systemic hypertension显示文摘 | Manso P H Amaral F T Vicente W V | 2007 | Int J Cardiol2007，118，3： | 1 |
| 18 | The formation mechanism of phase inversion membranes显示文摘 | Strathmann H Kock K Amar P | 1975 | Desalination1975，16，： | 1 |
| 19 | Leukocytosis and increasrd risk of atrial fibrillation after general thoracic surgery显示文摘 | Amar D Goen Ka A Zhang H | 2006 | Annthorac Surg2006，82，3： | 1 |
| 20 | Competing autonomic mechanisms precede the onset of postoperative atrial fibrillation显示文摘 | Amar D Zhang H Miodownik S | 2003 | J Am Coll Cardiol2003，42，7： | 1 |
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