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| 1 | 影响肠道细菌发酵因素的体外研究显示文摘目的 : 体外研究不同因素对肠道细菌发酵产生短链脂肪酸的影响 ,为膳食改善肠道功能提供依据。方法 : 在体外进行细菌培养 ,用稳定性同位素标记的葡萄糖作底物 ,用气相色谱 -同位素比值质谱法测定短链脂肪酸。用荧光染色法计数细菌数量。结果 : 结果显示细菌数量高 ,短链脂肪酸产生多 ,p H=7时产生的短链脂肪酸最多 ;添加酪蛋白可增加短链脂肪酸的产生及细菌数量 ;13 C-葡萄糖不但被发酵产生短链脂肪酸 ,而且也被用于细菌增殖。结论 : 人体肠道细菌发酵产生短链脂肪酸的能力受细菌数量、p H及底物不同的影响 ,此为通过选择不同膳食 (含益生原的食物如小麦、洋葱、香蕉、大蒜、韭菜、土豆等 )以调节结肠的功能提供了依据。 | 孙晓红 Heiner AM Elzinga H Vonk RJ | 2003 | 营养学报2003，25，3： | 7 |
| 2 | The receptor for the cytotoxic ligand TRAIL显示文摘 | Pan H Rourke K chinnaiyan AM | | 0，，： | 5 |
| 3 | Autoantibody profiles in autoimmune hepatitis and chronic hepatitis C identifies similarities in patients with severe disease显示文摘AIM To determine how the auto-antibodies(Abs) profiles overlap in chronic hepatitis C infection(CHC) and autoimmune hepatitis(AIH) and correlate to liver disease.METHODS Levels of antinuclear Ab, smooth muscle antibody(SMA) and liver/kidney microsomal-1(LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays. RESULTS We found that AIH patients had more severe liver disease as determined by elevation of total Ig G, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies(auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total Ig G. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1+ Ab CHC cases showed best overlap with AIH. CONCLUSION Auto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other. | Kawa Amin Aram H Rasool Ali Hattem Taha AM Al-Karboly Taher E Taher Jonas Bystrom | 2017 | World Journal of Gastroenterology2017，23，8： | 5 |
| 4 | 母亲妊娠期焦虑抑郁对孩子应激性心率及血压的影响显示文摘心理障碍,包括焦虑和抑郁在妊娠期间十分常见。该研究目的在于确定母亲的这些心理障碍是否会对后代的心血管反应产生影响。方法:对231名孕妇的心理状态进行评定,在其后代(n=216)7~9岁时进行视频压力反应测试。测定静息时、观看压力视频时和恢复期的心率及血压水平。 | 刘莉 叶鹏 Fan F Zou Y Tian H Zhang Y Zhang J Ma X Meng Y Yue Y Liu K Dart AM | 2015 | 中华高血压杂志2015，23，6： | 5 |
| 5 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 6 | 缺血期补充硝酸甘油对离体大鼠心脏心肌缺血再灌注损伤的作用显示文摘目的:观察离体大鼠心脏缺血期补充一氧化氮(NO)供体对缺血再灌注损伤的影响。 方法:将26只离体大鼠心脏缺血30分,再灌注60分。分为两组,用药组(15只)及对照组(11 只)。用药组于缺血期给予4.4×10- 3 mm ol/L硝酸甘油(nitroglycerin,NTG,一种NO供体),碳酸氢盐缓冲液灌注。对照组仅给予碳酸氢盐缓冲液灌注。全部心脏均测定NO释放量、肌酸激酶漏出量及(或)心脏功能。 结果:用药组大鼠心脏,使用NTG表现为两种效应。其中部分大鼠心脏(非心室颤动组,n= 7),NTG增加肌酸激酶漏出量,减弱再灌注期心脏功能的恢复,伴随缺血期NO释放量的增加。对另一部分大鼠心脏(心室颤动组,n= 8),NTG减少肌酸激酶的释放,但心脏于再灌注期持续心室颤动,缺血期NO释放量无明显增加。 结论:缺血期给予同一剂量NTG对心肌缺血再灌注损伤产生双重效应,既可增加心肌损伤,又可减轻心肌损伤。 | 刘海波 Takayuki T su ji Fum io Y am amoto Tosh ia Fujisato Hidekazu H irai Fu jio Miyaw aki | 1999 | 中国循环杂志1999，14，4： | 3 |
| 7 | 用气相色谱-同位素比值质谱法测定体外肠道细菌发酵产生的短链脂肪酸显示文摘目的 :了解肠道细菌发酵产生短链脂肪酸的情况 ,为乳糖不耐症状的发生提供依据。方法 :在体外进行细菌培养 ,用稳定性同位素标记的葡萄糖作底物 ,用气相色谱 -同位素比值质谱法测定短链脂肪酸。结果 :细菌纯培养显示不同菌株产生的短链脂肪酸不同。人体粪便培养表明不同人体产生的短链脂肪酸的种类相同 ,而各种类数量不同。结论 :所测定的人体肠道发酵产生短链脂肪酸的能力不同 。 | 孙晓红 Heiner AM Elzinga H Vonk RJ | 2002 | 贵阳医学院学报2002，27，2： | 3 |
| 8 | Human urotensinⅡis a potent vasoconstrictory and agonist for the orphan receptor GPR14 显示文摘 | Ames R S Sarau H M Chambers J K | 1999 | Nature1999，401，6750： | 3 |
| 9 | 非甾体抗炎药应用中,环氧合酶2、不对称二甲基精氨酸与心血管危害的关系显示文摘已有大规模、安慰剂对照试验确定了非甾体类抗炎药(nonsteroidal anti—inflammatory drugs,NSAIDs)具有心血管危害性:这归因于环氧合酶2(cyclooxygenase,COX-2)的心脏保护产物受到抑制,尤其是前列环素(prostacyclin,PG12)。NSAID降低心脏保护作用的另一种机制可能是通过增强肾脏中甲基精氨酸的形成来限制一氧化氮在整个脉管系统中的作用。 | Ricciotti E Castro C Tang SY Briggs WTE West JA Malik D Rhoades SD Meng H Li X Lahens NF Sparks JA Karlson EW Weljie AM Griffin JL FitzGerald GA6 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 3 |
| 10 | Cytokines in alcoholic and nonalcoholic steatohepatitis显示文摘 | Tilg H Diehl AM | | 0，，： | 2 |
| 11 | 在确诊并已接受治疗的原发性高血压患者中,炎症、内皮功能障碍和交感神经激活与血压之间的关系显示文摘研究结果表明,炎症、内皮功能紊乱、交感神经系统慢性激活在高血压发病机制中起重要作用。目前临床上关于血压与炎症、内皮功能紊乱以及交感神经系统激活之间的关系还不明确。该研究评估在确诊并已接受治疗的原发性高血压患者中,炎症[高敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)]、内皮细胞功能紊乱(内皮素1)和交感神经慢性激活(血浆肾上腺素和去甲肾上腺素)的生物标记物水平是否与血压的测量值相关。研究者同时试图应用血压和上述标记物之间的关系诊断顽固性高血压,并探讨降压药物对上述生物标记物的影响。 | Tycinska AM Mroczko B Musial WJ Sawicki R Kaminski K Borowska H Sobkowicz B Szmitkowski M. 叶鹏 | 2011 | 中华高血压杂志2011，19，11： | 2 |
| 12 | Bradykinin-induced reduction in collagen gene expression involve prostacyclin显示文摘 | Gallagher AM Yu H Printz MP | 1998 | Hypertension1998，32，： | 1 |
| 13 | Evaluation of ^18F-fluorodeoxyglucose positron emission tomography and computed tomography with histopathologic correlation in the initial staging of head and neck cancer显示文摘 | Hannah A Scott AM Tochon-Danguy H | 2002 | Ann Surg2002，236，2： | 1 |
| 14 | Effects of bisphenol A on adult male mouse fertility显示文摘 | Al-Hiyasat AS Darmani H Elbetieha AM | 2002 | Eur J Oral Sci2002，110，： | 1 |
| 15 | Complete genomes phylogenetic relatedness and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes显示文摘 | Courouce AM Magnius LO | 1994 | Virology1994，198，2： | 1 |
| 16 | A functional module of yeast mediator that governs the dynamic range of heat-shock gene expression显示文摘 | Singh H Erkine AM Kremer SB | 2006 | Genetics2006，172，4： | 1 |
| 17 | Meconium aspiration produces airway hyperresponsiveness and eosinophilic inflammation in a mufine model显示文摘 | Khan AM Elidemir O Epstein CE Lally KP Xue H Blackbum M | 2002 | Am J Physiol Lung Cell Moll Physiol2002，283，4： | 1 |
| 18 | Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-α transgenic mice显示文摘 | H uber SA Feldman AM Sartini D | 2006 | Circ Res2006，99，10： | 1 |
| 19 | 16-MDCT in the detection of occult wrist fractures:a comparison with skeletal scintigraphy显示文摘 | Groves AM Cheow H Balall K | 2005 | AJR2005，184，5： | 1 |
| 20 | Angiogen-sis and angiogenic growth factors in middle ear chol-esteatoma显示文摘 | SUDHOFF H DAZERT S GONZALES AM | 2000 | Am J Otol2000，21，6： | 1 |
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