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	题名	作者	年代	出处	被引量
1	Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation.	MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener	2006	World Journal of Gastroenterology2006，12，35：	3
2	The feasibility of integrating ME-TVC+MEE with azzour south power plant:Economic evaluation显示文摘	F N Alasfour A O Bin Amer	2006	Desalination2006，，197：	1
3	Simultaneous measurement of lateral and normal forces with an optical-beam-deflection atomic force microscope显示文摘	Meyer G Amer N M	1990	Appl Phys Lett1990，57，20：	1
4	Punctate inner choroidopathy 显示文摘	Amer R Lois N	2011	Surv Oph- thaimol2011，56，1：	1
5	Availability of barley straw application on oil spill clean up 显示文摘	HUSSEIEN M AMER A A EL-MAGHRABY A TAHA N A	2009	International Journal of Environmental Science and Technology2009，6，1：	1
6	Nonlinear response of composite steel-concrete bridges 显示文摘	Wegmaller A W Amer H N	1977	Composite and Structures1977，7，2：	1
7	Novel optical approach to atomic force microscopy 显示文摘	Meyer G Amer N M	1988	Appl Phys Lett1988，53，12：	1
8	Fluoride removal from brackish water by electrodialysis显示文摘	Z Amer B Bariou N Mameri	2001	Desalination2001，133，：	1
9	Punctate inner choroidopathy 显示文摘	Amer R Lois N	2011	Surv Oph- thalmo12011，56，1：	1
10	Communication paradigms for sensor net- works 显示文摘	Niculescu D Americ N	2005	IEEE Communications Magazine2005，43，3：	1
11	Availability of barley straw application on oil spill clean up 显示文摘	HUSSEIN M AMER A A EL-MAGHRABY A TAHA N A	2009	International Journal of Environmental Science and Technology2009，6，：	1
12	Thermal analysis of METVC + MEE desalination systems 显示文摘	ALAFOUR F N DARWISH M A BIN AMER A O	2005	Desalination2005，174，39：	1
13	Thermal analysis of ME - TVC + MEE desalination systems 显示文摘	ALASFOUR F N DARISH M A BIN AMER A O	2005	Desalination2005，174，：	1
14	Vascular effects of apelin in vivo in man显示文摘	Japp A G Cruden N L Amer D A		0，，11：	1
15	Communication paradigms for sensor networks 显示文摘	Niculescu D Americ N L	2005	IEEE Communications Magazine2005，43，3：	1
16	Concurrent multipath transfer during path failure显示文摘	NATARAJAN E EKIZ N AMER P D	2009	Computer Communication2009，32，：	1
17	Development of a SYBR Green I based real-time RT-PCR assay for detection and quantification of bovine eoronavirus显示文摘	Amer H M Almajhdi F N	2011	Mol Cell Probes2011，25，23：	1
18	Fluoride removal from brackish water by electrodialysis显示文摘	Amer Z Bariou B Mameri N		0，，03：	1
19	Efficiency of barley bran and oat bran in ameliorating blood lipid profile and the adverse histological changes in hypercholesterolemic male rats显示文摘	Rabey H E Al-seeni M N Amer H M	2013	Biomed Research International2013，，26：	1
20	Communication paradigms for sensor networks显示文摘	Niculescu D Americ N L	2005	IEEE Communications Magazine2005，43，3：	1

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