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| 1 | Treatment of hepatitis C virus genotype 4 with peginterferon alfa-2a: Impact of bilharziasis and fibrosis stage显示文摘AIM: To evaluate pegylated interferon alpha2a (PegIFN- α2a) in Egyptian patients with HCV genotype 4, and the impact of pretreatment viral load, co-existent bilharziasis and histological liver changes on response rate. METHODS: A total of 73 na?ve patients (61 with history of bilharziasis) with compensated chronic HCV genotype 4 were enrolled into: group A (38 patients) who received 180 mg PegIFN-alpha2a subcutaneously once weekly for a year and group B (35 patients) received IFN alpha-2a 3 MU 3 times weekly. Ribavirin was added to each regimen at a dose of 1200 mg. Patients were followed for 72 wk and sustained response was assessed. RESULTS: Significant improvement in both end of treatment response (ETR) (P < 0.002) and sustained response (SR) (P < 0.05) was noted with pegylated interferon, where ETR was achieved in 29 (76.3%) and 14 patients (40%) in both groups respectively, and 25 patients in group A (65.8%) and 9 (25.7%) in group B could retain negative viraemia by the end of follow up period. Sustained virological response (SVR) showed a significant negative correlation with age and positive correlation with pretreatment inflammation in patients receiving PegIFN. Viral clearance after 3 mo of therapy was associated with high incidence of ETR and SR (P < 0.001), but without significant difference between both forms of interferon. Significant improvement in response was achieved in patients with high grade fibrosis (grade 3 and 4) with PegIFN-α2a, where SR was seen in 5 out of 13 patients in group A, but none in group B. There was no significant difference in response betweenbilharzial and non-bilharzial patients in both groups. In terms of safety and tolerability, neutropenia was the predominant side effect; both drugs were comparable. CONCLUSION: PegIFN-α2a combined with ribavirin results in improvement in sustained response in HCV genotype 4, irrespective of history of bilharzial infestation. | MF Derbala SR Al Kaabi NZ El Dweik F Pasic MT Butt R Yakoob A Al-Marri AM Amer N Morad A Bener | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | Pupillography as an objective indicator of fatigue显示文摘 | Morad Y Lemberg H Yofe N | 2000 | Curr Eye Res2000，21，1： | 1 |
| 3 | Calcium chan-nel dysfunction in inferior colliculus neurons of the ge-netically epilepsy-prone rat显示文摘 | N’gouemo P Faingold CL Morad M | 2009 | Neuropharmacology2009，56，3： | 1 |
| 4 | Genetic algorithms in integrated process planning and scheduling显示文摘 | MORAD N ZALZALA A M S | | 0，，02： | 1 |
| 5 | Development, characterization and theapplication of hybrid materials in eoagulation/floccuta- tion of wastewater:a review显示文摘 | Lee K Morad N Teng T | 2012 | Chemical Engineering Journal2012，203，5： | 1 |
| 6 | Flocculation activity of novel ferric chloride-polyacrylamide (FeCl3-Pam) hybrid polymer显示文摘 | Lee K Teng T Morad N | 2011 | Desalination2011，266，13： | 1 |
| 7 | Diagenesisand Formation - Water Chemistry of Triassic Reservoir Sandstones from Southern -Tunisia 显示文摘 | MORAD S’BEN ISMAIL H N DE ROS L F | 1994 | Sedimentology1994，41，6： | 1 |
| 8 | Treatment of terasil Red R dye wastewater using H2OJpyridine/Cu ( lI ) system 显示文摘 | Lim C L Morad N Teng T T | 2009 | Journal of Hazar- dous Materials2009，168，1： | 1 |
| 9 | Genetic algorithms in integrated process planning and scheduling显示文摘 | Morad N Zalzala A | | 0，，02： | 1 |
| 10 | Development, Characterization and the Application of Hybrid Ma- terials in Coagulation/Flocculation of Wastewater:a Review 显示文摘 | Lee K E Morad N Teng T T | 2012 | Chemical Engineering Journal2012，203，5： | 1 |
| 11 | Development, Characterization and the Application of Hybrid Materials inCoagulation/Flocculation of Wastewater: A Review 显示文摘 | Lee K E Morad N Teng T T | 2012 | Chemical Engineering Journal2012，203，1： | 1 |
| 12 | Development, characterization and the application of hybrid materials in coagulation/flocculation of wastewater: A review显示文摘 | Lee K E Morad N Teng T T | 2012 | Chem Eng J2012，203，： | 1 |
| 13 | Magnetic nanoparticle(Fe3O4)impregnated onto tea waste for the removal of nickel(II)from aqueous solution显示文摘 | PANNEERSELVAM P MORAD N TAN KA | 2011 | Journal of Hazardous Materials2011，186，1： | 1 |
| 14 | Comparative study on the effectiveness of hydrophobically modified cationic polyac- rylamide groups in the flocculation of kaolin显示文摘 | Lee KE Morad N Poh BT | 2011 | Desalina- tion2011，，270： | 1 |
| 15 | Flocculation of kaolin in water using novel calcium chloride-polyacrylamide (CaC12-PAM) hybrid polymer显示文摘 | Lee K E Teng T T Morad N | 2010 | Sep Purif Technol2010，75，： | 1 |
| 16 | Flocculation activity of novel ferric chloride-polyacrylamide (FeC13-PAM) hybrid polymer显示文摘 | Lee K E Teng T T Morad N | 2011 | Desalination2011，266，： | 1 |
| 17 | Synthesis and characterization of hydrophobically modified cationic acrylamide copolymer 显示文摘 | Lee K E Poh B T Morad N | 2008 | International Journal of Poly- mer Analysis and Characterization2008，13，2： | 1 |
| 18 | Magnetic nanoparticle(Fe3O4)impregnated onto tea waste for the removal of nickel(11)from aqueous solution显示文摘 | Panneerselvam P Morad N Tan K A | 2011 | Hazard Mater2011，，186： | 1 |
| 19 | Molecular dynamics simulation for self-diffusion coefficients of ginger bioactive com- pounds in subcritical water with and without ethanol 显示文摘 | ANISA N I MORAD N A LWAI Y | 2016 | Fluid Phase Equilibr2016，407，： | 1 |
| 20 | Process modelling of combined degumming and bleaching in Palm Oil Refining using artificial neural net work显示文摘 | Morad N A Zin R M Yusof K M | | 0，，01： | 1 |
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