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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Hopf bifurcation for maps : a frequency - domain approach 显示文摘 | D'Amico M B Moiola J L Paolini E E | 2002 | IEEE Trans Circuits and Systems2002，49，： | 1 |
| 3 | Biochemicaloutcome after radical prostatectomy,external beam radiation therapy,or interstitial radiation the rapy for clinically localized prostate cancer显示文摘 | D'Amico A V Whittington R Malkowicz S B | 1998 | JAMA1998，280，11： | 1 |
| 4 | Efficacy of vocal function exercises as a method of improving voice production显示文摘 | Stemple JC Lee L D'Amico B | 1994 | J Voice1994，8，3： | 1 |
| 5 | Form finding and structural analysis of actively bent timber grid shells 显示文摘 | D' AMICO B KERMANI A ZHANG H | 2014 | Engineering Structures2014，81，24： | 1 |
| 6 | Optimisation of cross-section of actively bent grid shells with strength and geometric compatibility constraints 显示文摘 | D' AMICO B KERMANI A ZHANG H | 2015 | Computers & Structures2015，154，： | 1 |
| 7 | NCCN clinical practice guidelines in oncology: prostate cancer显示文摘 | Mohler J Bahnson R R Boston B Busby J E D' Amico A Eastham J A | 2010 | J Natl Compr Canc Netw2010，8，： | 1 |
| 8 | A Multivariate Statistical Analysis on the Consumers of Organic Products显示文摘 | Chinnici G Amico M D Pecorino B | 2002 | British Food Journal2002，104，345： | 1 |
| 9 | Biochemical outcome after radical prostatectomy,external beam radiation therapy,or interstitial radiation therapy for clinically localized prostate cancer显示文摘 | D'Amico V A Whittington R Malkowicz B S | 1998 | Jama1998，280，： | 1 |
| 10 | Causes of death in men with prevalent diabetes and newly diagnosed high- versus fa- vorable-risk prostate cancer显示文摘 | D' amico A V Braccioforte M H Moran B J | 2010 | Int J Radiat Oncol Biol Phys2010，77，5： | 1 |
| 11 | Bean homologs of the mammalian glucose regulated proteins:induction by tunicamycin and interaction with newly synthesized storage proteins in the endoplasmic reticulum显示文摘 | D'Amico L Valsasina B Daminati M G | 1992 | Plant J1992，2，： | 1 |
| 12 | Serum protein expression predicts recurrence in pa- tients with early-stage lung cancer after resection 显示文摘 | D' AMICO T A BROOKS K R JOSHI M B M | 2006 | The Annals of Thoracic Surgery2006，81，6： | 1 |
| 13 | Internet addiction disorder An Italian study显示文摘 | FERRARO G CACI B D'AMICO A | 2007 | Cyberpsychol Behav2007，10，2： | 1 |
| 14 | Gambino, Mount Etna 1993-2005 : Anatomy of an Evolving Eruptive Cycle显示文摘 | Allard P Behncke B D'Amico S | 2006 | Earth Sci Rev2006，78，： | 1 |
| 15 | Biological function and clinical relevance of chro- mogranin A and derived peptides显示文摘 | D'AMICO M A GHINASSI B IZZICUPO P | 2014 | Endocr Con- nect2014，29，： | 1 |
| 16 | The impact of pulmonary hy- pertension on morbidity and mortality following major lung resec- tion 显示文摘 | Wei B D'Amico T Samad Z | 2013 | European journal of cardio - thoracic surgery : official jour- nal of the European Association for Cardio-tboracic Surgery2013，，： | 1 |
| 17 | Light chain deposition disease with renal involvement: clinical characteristics and prognostic factors显示文摘 | Claudio Pozzi Marco D’Amico Giovanni B Fogazzi Simona Curioni Franco Ferrario Sonia Pasquali Giacomo Quattrocchio Cristiana Rollino Siro Segagni Francesco Locatelli | 2003 | American Journal of Kidney Diseases2003，，6： | 1 |
| 18 | Pretreatment PSA velocity and risk of death from prostate cancer following external beam radiation therapy显示文摘 | D'Amico AV Renshaw AA Sussman B | 2005 | JAMA2005，294，4： | 1 |
| 19 | The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-respon- sive element-binding protein-dependent pathways 显示文摘 | D'Amico M Hulit J Amanatullah DF Zafonte BT Albanese C Bouzahzah B | 2000 | Biol Chem2000，275，32： | 1 |
| 20 | Molecular characterization of extended spectrum β-lactamases produced by nosocomial isolates of Enterobacteriaceae from an Italian nationwide survey显示文摘 | PERILLI M AMICO E D SEGATORE B | 2002 | J Clin Microbiol2002，40，2： | 1 |
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