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| 1 | 术中应用荧光素钠有利于胶质母细胞瘤浸润边缘的手术切除(英文)显示文摘Objective Extent of resection is an important prognostic factor in patients undergoing surgery for glioblastoma( GBM).Recent evidence suggests that intravenously administered fluorescein sodium associates with tumor tissue,facilitating safe maximal resection of GBM. In this study,the authors evaluate the safety and utility of intraoperative fluorescein guidance for the prediction of histopathological alteration both in the contrast-enhancing( CE) regions,where this relationship has been established,and into the nonCE( NCE),diffusely infiltrated margins. Methods Thirty-two patients received fluorescein sodium( 3 mg/kg) intravenously prior to resection. Fluorescence was intraoperatively visualized using a Zeiss Pentero surgical microscope equipped with a YELLOW 560 filter.Stereotactically localized biopsy specimens were acquired from CE and NCE regions based on preoperative MRI in conjunction with neuronavigation. The fluorescence intensity of these specimens was subjectively classified in real time with subsequent quantitative image analysis,histopathological evaluation of localized biopsy specimens,and radiological volumetric assessment of the extent of resection.Results Bright fluorescence was observed in all GBMs and localized to the CE regions and portions of the NCE margins of the tumors,thus serving as a visual guide during resection. Gross-total resection( GTR) was achieved in 84% of the patients with an average resected volume of 95%,and this rate was higher among patients for whom GTR was the surgical goal( GTR achieved in 93. 1% of patients,average resected volume of 99. 7%). Intraoperative fluorescein staining correlated with histopathological alteration in both CE and NCE regions,with positive predictive values by subjective fluorescence evaluation greater than 96% in NCE regions. Conclusions Intraoperative administration of fluorescein provides an easily visualized marker for glioma pathology in both CE and NCE regions of GBM. These findingssupport the use of fluorescein as a microsurgical adjunct for guiding GBM resection to facilitate safe maximal removal. | Neira JA Ung TH Sims J Malone HR Chow DS Samanamud JL Zanazzi GJ Guo X Bowden SG Zhao B Sheth SA McKhann GM 2nd Sisti MB Canoll P D'Amico RS Bruce JN | 2016 | 中华神经外科疾病研究杂志2016，15，5： | 2 |
| 2 | Phase Ⅰ pharmacokinetic study of tea polyphenols following single - dose administration of epigallocatechin gallate and polyphenon E显示文摘 | Chow HHS Cai Y Alberts DS | 2001 | Cancer Epidemiol Biomark Prey2001，10，： | 1 |
| 3 | Liver fibrosis:an intravoxel incoherent motion (IVIM)study 显示文摘 | Chow AM Gao DS Fan SJ | 2012 | J Magn Reson Imaging2012，36，1： | 1 |
| 4 | Long- term results of robotic assisted laparoscopic sacrocolpopexy for the treatment of high grade vaginal vault prolapse 显示文摘 | Elliott DS Kramheck AE Chow GK | 2006 | J Urol2006，176，2： | 1 |
| 5 | Deep hypothermic circulatory arrest in adults undergoing aortic surgery:local experience显示文摘 | Chong SY Chow MY Kang DS | 2004 | Ann Acad Med Singapore2004，33，3： | 1 |
| 6 | Deep hypothermic circulatory arrest in adults undergoing aortic surgery:local experience显示文摘 | Chow MY gang DS | 2004 | Ann Acad Med Singapore2004，33，3： | 1 |
| 7 | Cremophor-free intravenous microemulsions for paclitaxel I: formulation, cytotoxicity and hemolysis 显示文摘 | Nornoo AO Osborne DW Chow DS | 2008 | lnt JPharm2008，349，12： | 1 |
| 8 | Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitrocamptothecin显示文摘 | Chow DS Gong L Wolfe MD | 2000 | Ann NY Acad Sci2000，922，： | 1 |
| 9 | Robotic-assisted laparoscopic saerocolpopexy for treatment of vaginal vault prolapse 显示文摘 | Di Marco DS Chow GK Gettman MT | 2004 | Urology2004，63，： | 1 |
| 10 | Long-term results of robotic assisted laparoscopic sacrocolpopexy for the treatment of high grade vaginal vault prolapse显示文摘 | Elliott DS Krambeck AE Chow GK | 2006 | J Urol2006，176，： | 1 |
| 11 | Liver fibrosis:an intravoxel incoherent motion(IVIM)study显示文摘 | Chow AM Gao DS Fan SJ | 2012 | J Magn Reson Imaging2012，36，1： | 1 |
| 12 | The effects of load can'iage and bracing on the balance of schoolgirls with adolescent idiopathic scolio- sis显示文摘 | Chow DH Leung DS Holmes AD | 2007 | Eur Spine J2007，16，9： | 1 |
| 13 | Exhaled air dispersion distances during noninvasive ventilation via different Respironics face masks显示文摘 | Hui DS Chow BK Ng ss | 2009 | Chest2009，136，4： | 1 |
| 14 | Formulation and stability of busulfan for intravenous administration in high-dose chemotherapy显示文摘 | Bhagwatwar HP Phadungpojna S Chow DS | 1996 | Cancer Chemother Pharmacol1996，37，： | 1 |
| 15 | Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 92nitro-camptothecin显示文摘 | Chow DS Gong L Wolfe MD | 2000 | Ann N Y Acad Sci2000，922，： | 1 |
| 16 | Liver fibrosis:an intravoxel incoherent motion (IVIM) study显示文摘 | Chow AM Gao DS Fan SJ | | 0，，： | 1 |
| 17 | Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitro-camptothecin显示文摘 | Gong L Wolfe MD | 2000 | Ann N Y Acad Sci2000，922，： | 1 |
| 18 | Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitrocamptothecin显示文摘 | CHOW DS GONG L WOLFE MD | 2000 | Ann N Y Acad Sci2000，922，： | 1 |
| 19 | Modified lactone/carboxylate salt equilibria in vivo by liposomal delivery of 9-nitro-camptothecin显示文摘 | Chow DS Gong L Wolfe MD | 2000 | Ann N Y Acad Sci2000，922，： | 1 |
| 20 | Insulin degludec/insulin aspart versus biphasic insulin aspart 30in Asian patients with type 2diabetes inadequately controlled on basal or pre-/self-mixed insulin:A 26-week,randomised,treat-to-target trial显示文摘 | Kaneko S Chow F Choi DS | 2015 | Diabetes Res Clin Pract2015，107，1： | 1 |
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