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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | A scenario-based reliability analysis approach for component-based software 显示文摘 | Yacoub S Cukic B Ammar H H | 2004 | IEEE Transactions on Reliability2004，53，4： | 1 |
| 3 | A Scenario-Based Reliability Analysis Approach for Component-Basod Software显示文摘 | Yacoub S Cukic 1 Ammar H | 2004 | IEEE Transactions on Reliability2004，53，4： | 1 |
| 4 | Crystallinity of nano C-LiFePO4 prepared by the polyol process显示文摘 | Azib T Ammar S Nowak S | 2012 | Journal of Power Sources2012，217，： | 1 |
| 5 | Electrochemical oxidation of 1,3,5-trimethoxybenzene in aqueous solutions at gold oxide and lead dioxide electrodes显示文摘 | Hamza M Ammar S Abdelhedi R | | 0，，： | 1 |
| 6 | Applying fuzzy-set theory to Perfor-mance evaluation显示文摘 | Wright R | 2000 | Socio-Economic Planning Sciences2000，，12： | 1 |
| 7 | Effect of the server capacity distribution on the optimal control of a bulk service queueing system显示文摘 | Lotfi T Ammar S | 2003 | Chaos Solitons and Fractals2003，18，5： | 1 |
| 8 | Comparison of feature extractors for real-time object detection on android smartphone 显示文摘 | KHAIRULMUZZAMMIL S NURUL A AMMAR A | 2013 | Journal of Theoretical and Applied Information Technology2013，47，1： | 1 |
| 9 | Using of tara flour as partialsubstitute of wheat flour in bread making 显示文摘 | AMMAR M S HEGAZY A E BEDEIR S H | 2009 | World Journal of Dairy &Food Sciences2009，4，2： | 1 |
| 10 | Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of( Rhaponticum acaule DC) growing wild in Tunisia显示文摘 | Boussaada O Ammar S Saidana D | 2008 | Microbiol Res2008，163，1： | 1 |
| 11 | Electrochemical degradation of 4-chloroguaiacol for wastewater treatment using PbO2 anodes显示文摘 | SAMET Y CHAABANE ELAOUD S AMMAR S ABDELHEDI R | 2006 | Journal of Hazardous Materials2006，138，3： | 1 |
| 12 | Assessment of metals speciation in sewage sludge and stabilized sludge from different wastewater tretment plants,Greater Cairo,Egypt显示文摘 | Lasheen M R Ammar N S | 2009 | Journal of Hazardous Materials2009，164，23： | 1 |
| 13 | Applied Catalysis B: Environmental显示文摘 | Flox C Ammar S Arias C | 2006 | 67 (1-2): 93-1042006，67，12： | 1 |
| 14 | Echocardiographic characteristics of electrocardiographically unrecognizedmyocardial infarctions in a community population显示文摘 | Ammar KA Samee S Makwana R | 2005 | Am J Cardiol2005，96，8： | 1 |
| 15 | Electrochemical degradation of 4-chloroguaiacol for wastewater treatment using PbO: anodes 显示文摘 | SAMET Y CHAABANE ELAOUD S AMMAR S | 2006 | Journal of Hazardous Materials2006，138，3： | 1 |
| 16 | Root cell characteristics of two wheat species differing in their sensitivity to NaCl in response to salt stress显示文摘 | Jbir N Ammar S Ayadi A 2003 | 2003 | Journal of Trace and Microprobe Techniques2003，21，4： | 1 |
| 17 | Insect Vector Interactions with Persistently Transmitted Viruses显示文摘 | Hoqenhout S A Ammar E D Whitfield A E | 2008 | Annual Review of Phytopathology2008，，46： | 1 |
| 18 | Comparison of three SN methods to correct for microbial contamination when assessing in situ protein degradability of fresh forages显示文摘 | Kamoun M Ammar H Th6wis A Beckers Y France J L6pez S | 2014 | Journal of Animal Science2014，92，11： | 1 |
| 19 | Layered nickel hydroxide salts: synthesis, characterization and magnetic behaviour in relation to the basal spacing 显示文摘 | Taibi M Ammar S Jouini N | 2002 | Journal of Materials Chemistry2002，12，11： | 1 |
| 20 | A methodology for architecture-level reliability risk analysis 显示文摘 | YACOUB S M AMMAR H H | 2002 | IEEE Transactions on Software Engineering2002，28，6： | 1 |
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