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| 1 | Hypoglycemic and antioxidant activities of Caesalpinia ferrea Martius leaf extract in streptozotocininduced diabetic rats显示文摘Objective: To evaluate the antidiabetic and antioxidant ef ects of aqueous ethanolic extract of Caesalpinia ferrea(C. ferrea) leaf in normal and streptozotocin(STZ) induced diabetic rats.Methods: Male Sprague-Dawley rats divided into 6 groups of 6 rats each were assigned into diabetic and non-diabetic groups. Diabetes was induced in rats by single intraperitoneal administration of STZ(65 mg/kg body weight). C. ferrea extract at the doses of 250 and 500 mg/kg body weight was orally administered to both diabetic and non-diabetic animals for a period of 30 days. After completion of experimental duration serum, liver and pancreas were used for evaluating biochemical and histopathological changes.Results: Oral administration of C. ferrea leaf extract significantly reduced elevated serum glucose, α-amylase, liver function levels and signii cantly increased serum insulin, total protein and body weight as well as improved lipid proi le due to diabetes. Furthermore, the treatment resulted in a marked increase in glutathione peroxidase, superoxide dismutase, catalase and reduced glutathione, and diminished levels of lipid peroxidation in liver and pancreas of diabetic rats. Histopathological studies demonstrated the reduction in the pancreas and liver damage and coni rmed the biochemical i ndings.Conclusions: From the present study, it can be concluded that the C. ferrea leaf extract ef ectively improved hyperglycaemia while inhibiting the progression of oxidative stress in STZ-induced diabetic rats. Hence, it can be used in the management of diabetes mellitus. | Sherien Kamal Hassan Nermin Mohammed El-Sammad Amria Mamdouh Mousa Maha Hashim Mohammed Abd el Razik Hussein Farrag Amani Nassir Eldin Hashim Victoria Werner Ulrike Lindequist Mahmoud Abd El-Moein Nawwar | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，6： | 3 |
| 2 | Production of yoghurt from sheep' s milk which had been concentrated by reverse osmosis and stored frozen 2 Compositional, microbiological, sensory and physical characteristics of yoghurt显示文摘 | LEANDROS P V AMRIA C K CHRISTOPHOROS P P | 1996 | Food Research International1996，，29： | 1 |
| 3 | Administrationofresveratrol:Whatformulationsolutionstobioavailabilitylimitations显示文摘 | AMRIA CHAUMEILJC SFARS etal | 2012 | JControlRelease2012，158，2： | 1 |
| 4 | The mouse and human Flil genes are similarly regulated by Ets factors in T cells 显示文摘 | Svenson JL Chike-Harris K Amria MY | 2010 | Genes Immun2010，11，2： | 1 |
| 5 | Tissue microarrayanalysis of the prognostic value of E-cadherin,Ki67? p53,p27, survivin and MSH2 expression in upper urinary tracttransitional cell carcinoma显示文摘 | Fromont G Roupret M Amria N | 2005 | Eur UroU2005，48，5： | 1 |
| 6 | Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma显示文摘 | Goldstein O Q Hajiaghamohseni L M Amria S | 2008 | Cancer Immunol Immunother2008，57，10： | 1 |
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