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| 1 | Framingham研究中年轻成人缺血性脑卒中发病的时间趋势显示文摘中年脑卒中对残疾造成的相关生活质量损失影响极大。在这个年龄段,缺血性脑卒中发病率可能会增加。该研究调查了按照中年和老年发病的脑卒中进行分层的社区样本中,缺血性脑卒中发病率和脑卒中危险因素变化的长期趋势。Framingham研究自1948年开始对脑卒中事件进行监测,研究人员对年龄35.<55和>55岁的患者开始进行随访观察,使用Cox模型检查经年龄和性别调整后的10年缺血性脑卒中发病率。在4个时期内进行线性趋势检验,并控制各期之间的时间距离。 | 刘莉(译) 叶鹏(审校) Aparicio HJ Himali JJ Satizabal CL Pase MP Romero JR Kase CS Beiser A S Seshadri S | 2019 | 中华高血压杂志2019，27，8： | 2 |
| 2 | Translational pancreatic cancer research:a comparative study on patient-derived xenograft models显示文摘AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude mice.METHODS This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical characteristics.CONCLUSION In our experience, the faster development andgreatest number of viable xenografts could make the subcutaneous model the best option for experimentation in pancreatic cancer. | Mercedes Rubio-Manzanares Dorado Luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas Juan Manuel Praena-Fernández Juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz | 2018 | World Journal of Gastroenterology2018，24，7： | 2 |
| 3 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 4 | 载脂蛋白E及脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病、死亡风险的关系显示文摘膳食脂肪对心血管健康和死亡率的作用仍然存在争议。由于载脂蛋白E(apolipoprotein E,APOE)是脂质运输和代谢的核心,研究者通过检测APOE—ε4基因型,评估了血浆脂肪酸与脑卒中、冠状动脉粥样硬化性心脏病(冠心病)、死亡风险之间的关系。 | 刘青 叶鹏 Satizabal CL Samieri C Davis-Plourde KL Voetsch B Aparicio HJ Pase MP Romero JR Helmer C Vasan RS Kase CS Debette S Beiser AS Seshadr Sudhai | 2018 | 中华高血压杂志2018，26，11： | 2 |
| 5 | Leptin and Ob-Rb receptor isoform in the human digestive tract during fetal development显示文摘 | Aparicio T Kermorgant S Darmoul D | 2005 | J Clin Endocrinol Metab2005，90，11： | 1 |
| 6 | Bottlenecks for plantrecruitment in woodland remnants: An ornithochorous shrub ina Mediterranean ‘relictual’ landscape 显示文摘 | González-Varoa J P Norab S Aparicio A | 2012 | Perspect Plant Ecol2012，14，11： | 1 |
| 7 | Measurement of The Degraded Depth iu Cementitious Materials by Automatic Digital image Processing 显示文摘 | Segura I Molero M Aparicio S | 2010 | Measurement science and technology2010，，21： | 1 |
| 8 | Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes显示文摘 | Aparicio S Chapman J Stupka E | 2002 | Science2002，297，： | 1 |
| 9 | The coat protein of prunus necrotic ringspot virus specifically binds to and regulates the conformation of its genomics RNA显示文摘 | Aparicio F Vilar M Perez - Paya'E Palla's V | 2003 | Virology2003，313，： | 1 |
| 10 | Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa 显示文摘 | Aparicio T Guilmeau S Goiot H | 2004 | Gastroenterology2004，126，： | 1 |
| 11 | Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement显示文摘 | Kermorgant S Aparicio T Dessirier V | | 0，，： | 1 |
| 12 | Review of the clinical experience with 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumors显示文摘 | APARICIO A WEBER J S | 2002 | Curr Opin Investig Drugs2002，3，： | 1 |
| 13 | Influence of saline stress on root hydraulic conductance and PIP expression in Arabidopsis显示文摘 | Martínez-Ballesta M C Aparicio F Pallás V | 2003 | Plant Physiology2003，160，： | 1 |
| 14 | Synthesis of hybrid silica Sol - Gel coatings containing Zn particles on carbon steel and Al/Zn coated carbon steel显示文摘 | PEPE A APARICIO M CERE S | 2005 | Materials Letters2005，59，： | 1 |
| 15 | Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes显示文摘 | Aparicio S Morrison A Gould A | 1995 | Proc Natl Acad Sci USA1995，92，5： | 1 |
| 16 | Real time implementation of a control system for exposure time ofCCD 显示文摘 | BORROMEO S APARICIO J L | 2005 | SPIE2005，5671，： | 1 |
| 17 | Review of the clinical experience with 5-azacytidine and 5-aza-2′-deoxycytidine in solid tumors显示文摘 | APARICIO A WEBER J S | 2002 | Curr Opin Investig Drugs2002，3，： | 1 |
| 18 | Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction Evidence for PI3 kinase and PKC involve- ment显示文摘 | Kermorgant S Aparicio T Dessirier V | 2001 | Carcinogenesis2001，22，7： | 1 |
| 19 | Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: Analysis of genes flanking the polyketide synthase显示文摘 | Molnr I Aparicio J F Haydock S F | 1996 | Gene1996，169，1： | 1 |
| 20 | Leptin counteracts sodium butyrate-induced apoptosis in human colon cancer HT-29 cells via NF-kappa B signaling显示文摘 | Rouet-Benzineb P Aparicio T Guilmeau S | 2004 | J Biol Chem2004，279，16： | 1 |
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