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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 3 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 4 | Association between EGF +61A/G polymorphism and gastric cancer in Caucasians显示文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men. | Ana Paula Araújo Bruno M Costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra Costa Rui M Reis Rui Medeiros | 2011 | World Journal of Gastroenterology2011，17，4： | 3 |
| 5 | Prevalence of musculoskeletal pain among teachers显示文摘 | Cardoso J P Ribeiro I Q B Araújo T M | 2009 | Revista Brasileira de Epidemiologia2009，，04： | 1 |
| 6 | Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment显示文摘 | Santos L H M L M Araújo A N Fachini A Pena A Delerue-Matos C Montenegro M C B S M | | 0，，： | 1 |
| 7 | Industrial application of AISI 4340 steels treated in cathodic cage plasma nitriding technique显示文摘 | RIBEIRO K J B de SOUSA R R M de ARAJO F O | 2008 | Materials Science and Engineering:2008，479，： | 1 |
| 8 | Anatomical description of the facet joint innervation and its implication inthe treatment of recurrent back pain显示文摘 | Masini M Paiva WS Araújo AS Jr | 2005 | J NeurosurgSci2005，49，4： | 1 |
| 9 | Screening analysis of natural gas with respect to methane content by near-infrared spectrometry显示文摘 | Hebertty V. Dantas Mayara F. Barbosa Elaine C.L. Nascimento Pablo N.T. Moreira Roberto K.H. Galv?o Mário C.U. Araújo | 2014 | Microchemical Journal2014，，： | 1 |
| 10 | Modified Microelectrodes and Multivariate Calibration for Flow Injection Amperometric Simultaneous Determination of Ascorbic Acid,Dopamine,Epinephrine and Dipyrone显示文摘 | Angnes L Araújo M C U | 2000 | Analyst2000，125，11： | 1 |
| 11 | Climate change threatens European conservation areas显示文摘 | Araújo M B Alagador D Cabeza M | 2011 | Ecology Letters2011，14，5： | 1 |
| 12 | Bio-Oss collagen in the buccal gap at immediate implants:a 6-month study in the dog显示文摘 | Araújo M G Linder E Lindhe J | 2011 | Clin Oral Implants Res2011，22，1： | 1 |
| 13 | Potassium-modified Mg(NH2)2/2Li H system for hydrogen storage显示文摘 | Wang J H Liu T Wu G T Li W Liu Y F Moysés Araújo C Scheicher R H Blomqvist A Ahuja R Xiong Z T Yang P Gao M X Pan H G Chen P | 2009 | Angewandte Chemie International Edition2009，48，： | 1 |
| 14 | Resistance of different fungal structures of Duddingtonia flagrans to the digestive process and predatory ability on larvae of Haemonchus contortus and Strongyloides papillo sus in goat feces显示文摘 | Artur K Campos J V Araújo M P | | 0，，： | 1 |
| 15 | A strategy for selecting calibration samples for multivariate modeling显示文摘 | FILHO H A D GALV(A)O R K H ARA(U)JO M C U | 2004 | Chemometrics and Intelligent Laboratory Systems2004，72，1： | 1 |
| 16 | The successive projections algorithm for variable selection in spectroscopic multicomponent analysis显示文摘 | ARA(U)JO M C U SALDANHA T C B GALV(A)O R K H | 2001 | Chemometrics and Intelligent Laboratory Systems2001，57，2： | 1 |
| 17 | Hypothalamic Inflammation and Obesity显示文摘 | Eliana P. Araújo Márcio A. Torsoni Lício A. Velloso | 2010 | Vitamins and Hormones2010，，： | 1 |
| 18 | Comparison of kineticstudy of CTMA+ removal of molecular sieveTi-MCM-41 synthesized with natural and commercialsilica显示文摘 | BRAGA FONTES M D S DE ARAúJO MELO D M DE CASTRO COSTA C | 2015 | Materials research2015，18，3： | 1 |
| 19 | Five (or so) challenges for species distribution modeling显示文摘 | Araújo M B Guisan A | | 0，，： | 1 |
| 20 | A green approach toward antibody purification:a sustainable biomimetic ligand for direct immobilization on (bio)polymeric supports显示文摘 | BARROSO T LOUREN O A ARA JO M | 2013 | Journal of Molecular Recognition2013，26，12： | 1 |
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