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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Increased tumorigenesis associated with loss of the tumor suppressor gene Cadml显示文摘 | van der Weyden L Arends MJ Rust AG | 2012 | Mol Cancer2012，11，： | 1 |
| 3 | Neointimalhyperplasia in early arteriovenous fistula failure 显示文摘 | ROY CHAUDHUHY P AREND L ZHANG J | 2007 | Am J KidneyDis2007，50，5： | 1 |
| 4 | Altrenogest treatment associated with a farrowing induction protocol to avoid early parturition in sows显示文摘 | Gaggini T S Perin J Arend L S | 2013 | Reproduction in Domestic Animals2013，48，3： | 1 |
| 5 | Advanced me thods in meta-analysis: multivariate approach and meta-regression显示文摘 | Van Houwelingen H C Arends L R Stijnen T | 2002 | Stat Med2002，21，4： | 1 |
| 6 | Low chloride stimulation of PGE2 release and COX-2 expression in a mouse macula densa cell line 显示文摘 | Yang Tianxin Park JM Arend L | 2000 | J Biol Chem2000，275，37： | 1 |
| 7 | Altrenogest treatment asso-ciated with a farrowing induction protocol to avoid early parturi-tionin sows显示文摘 | Gaggini T S Perin J Arend L S | 2013 | Reprod DomAnim2013，48，3： | 1 |
| 8 | Endovenous therapies of lower extremity varicosities : a meta-analysis 显示文摘 | van den Bos R Arends L Kockaert M | 2009 | J Vasc Surg2009，49，1： | 1 |
| 9 | Lightness and brightness over spatial illumination gradients 显示文摘 | Arend L E Goldstein R | 1990 | Journal of the Optical Society of America a-Optics Image Science and Vision1990，10，7： | 1 |
| 10 | A GIS-based support tool for sustain- able spatial planning in metropolitan areas显示文摘 | Gerrit J C Arend L | 2007 | Landscape and Urban Planning2007，80，2： | 1 |
| 11 | Seasonal and spatial distribution of extracellular enzymatic activities and microbial incorporation of dissolved organic substrates in marine sediments显示文摘 | Arend L Reil M | 1987 | Applied and Environmental Microbiology1987，53，8： | 1 |
| 12 | Myeloproliferative neo- plasms in Budd - Chiari syndrome and portal vein thrombosis : a meta - analysis 显示文摘 | Smalberg J H Arends L R Valla D C | 2012 | Blood2012，120，25： | 1 |
| 13 | Endovenous therapies of lower extremity varicosities: A meta-analysis 显示文摘 | Van den Bos R Arends L Kockaert M | 2009 | J Vasc Surg2009，49，1： | 1 |
| 14 | Treatment of C4d-positive acute humoral rejection with plasmapherasis and rabbit polyelonal antithymocyte globulin 显示文摘 | Shah A Nadasdy T Arend L | 2004 | Transplantation2004，77，9： | 1 |
| 15 | Detecting N-nitrosamines in drinking water at nanogram-per-liter levels using ammonia positive chemical ionization 显示文摘 | Charrois J W A Arend M W Froese K L | 2004 | Environmental Science Technology2004，38，18： | 1 |
| 16 | Altrenogest treat- ment associated with a farrowing induction protocol to avoid early parturition in sows 显示文摘 | Gaggini T S Perin J Arend L S | 2013 | Reprod Domestic Animal2013，48，3： | 1 |
| 17 | Detecting N-nitrosamines in drinking water at nanogram per liter levels using ammonia positive chemical ionization 显示文摘 | Charrois J W A Arend M W Froese K L | 2004 | Environmental Science & Technology2004，38，18： | 1 |
| 18 | Polymorphism in the IGF-Ⅰ gene:clinicalrelevance for short children born small for gestation age(SGA) 显示文摘 | Arends N Johnston L Hokken KA | 2002 | J Clin Endoceinol Metab2002，87，6： | 1 |
| 19 | Impact of moisture and UV degradation on Beauveria bassiana (Balsamo) Vuillemin conidial viability in turfgrass 显示文摘 | THOMPSON S R BRANDENBURG R L ARENDS J J | 2006 | Biological Control2006，39，3： | 1 |
| 20 | Neointimal Hyper plasia in early arteriovenous fiotula显示文摘 | Roy Chaudhry P Arend L Zhang J | 2007 | Am J Kidney Dis2007，50，： | 1 |
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