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| 1 | Measurement of circulating levels of VEGF-A,-C,and -D and their receptors,VEGFR-1 and -2 in gastric adenocarcinoma显示文摘AIM: To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A,-C,and -D,and their receptors,VEGFR-1 and -2 in gastric adenocarcinomas. METHODS: The serum levels of VEGF family members were measured in 76 control subjects and 76 patients with gastric adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements were correlated with clinco-pathological features and survival rates. RESULTS: The serum levels of VEGF-A and its receptor,VEGFR-1,were signifi cantly higher in patients with gastric cancer than in healthy donors (t = 2.3,P = 0.02 and t = 4.2,P < 0.0001,respectively). In contrast,the serum levels of VEGF-D were signif icantly higher in control subjects than in patients (t = 2.9,P = 0.004). There was no significant difference in serum levels of VEGF-C and VEGFR-2 between patients and controls. VEGF-C was associated with advanced tumor stage and presence of metastasis. VEGFR-1 was associated with metastasis,advanced overall stage,tumor differentiation and survival. VEGFR-2 levels were associated with poor tumor differentiation. There was no significant prognostic value for any of the VEGF family members or their receptors except for VEGFR-1 where high levels were associated with a poor overall survival. CONCLUSION: Serum VEGF levels vary significantly in the same cohort of patients with variable clinico-pathological features and prognostic values. The simultaneous measurement of VEGF receptors levels in sera may overcome the limitations of a single biomarker assay. | Mansour S Al-Moundhri A Al-Shukaili M Al-Nabhani B Al-Bahrani IA Burney A Rizivi SS Ganguly | 2008 | World Journal of Gastroenterology2008，14，24： | 32 |
| 2 | Pilot prospective randomized placebo - controlled triial of bilevel positive airway pressure in acute asthmatic attack显示文摘 | Soroksky A Stav D Shpirer IA | 2003 | Chest2003，123，： | 1 |
| 3 | Percutaneous coil occlusion of patent ductus arteriosus显示文摘 | Rothman A Lucas VW Sklansky MS Cocalis MW Kashani IA | 1997 | J Pediatr1997，130，3： | 1 |
| 4 | The efficacy and safety of argon plasma coagulation therapy in Barrett's esophagus 显示文摘 | Grade A J Susan IA Medlin SM | 1999 | Gastrointest Endosc1999，50，： | 1 |
| 5 | Closed reduction of the traumatically dislocation hip:a new technique显示文摘 | McMurtry IA Ouaie A | 2001 | Injury2001，32，： | 1 |
| 6 | What is the role of NSAIDS in- pre-emptive analgesia显示文摘 | Ochroch EA Mardini IA Gottsehalk A | 2003 | Drugs2003，63，24： | 1 |
| 7 | Pretreatment thrombocytosis as a prognostic factor in metastatic breast cancer显示文摘 | Stravodimou A Voutsadakis IA | 2013 | Int J Breast Cancer2013，2013，28： | 1 |
| 8 | Stiffness of systemic arteries in appropriate and small - for - gestational-age newborn infants 显示文摘 | Mor IA Uchida N Inomo A | 2012 | Pediatrics2012，118，3： | 1 |
| 9 | Gut modulator effects of Conyza bonariensis explain its traditional use in constipation and diarrhea显示文摘 | BUKHARI IA SHAH A J KHAN RA | 2013 | Eur Rev Med Pharmacol Sci2013，17，4： | 1 |
| 10 | Increased matenal plasma leptin in early pregnancy and risk of gestational diabetes mellitus 显示文摘 | Qiu c Will iams M A Vadachkor ia S | 2004 | Obstet Gynecol2004，103，3： | 1 |
| 11 | What is the role of NSAIDs inpre-emptive analgesia显示文摘 | Mardini IA Gottschalk A | 2003 | Drugs2003，63，24： | 1 |
| 12 | Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel 显示文摘 | Levite M Fleidervish IA Schwarz A | 1999 | J Autoimmun1999，13，1： | 1 |
| 13 | A prospective randomized controlled trial of tumour chemosensitivity assay directed chemotherapy versus physicians choice in patients with recurrent platinum-resistant ovarian cancer显示文摘 | Cree IA Kurbacher CM Lamont A | 2007 | Anticancer Drugs2007，18，9： | 1 |
| 14 | Inductively coupled plasma mass spectrometry for direct multi-el- ement analysis of diluted human blood and serum显示文摘 | Barany E Bergdahl IA Schtitz A | 1997 | J Anal At Spectrom1997，12，9： | 1 |
| 15 | Histone deacetylase 1 regulates retinal neurogene- sis in zebrafish by suppressing Wnt and Notch signaling path- ways 显示文摘 | Yamaguctd M Tonou-Fujimori N Komori A Maeda R Nojima Y IA H | 2005 | Development2005，132，13： | 1 |
| 16 | Is there any relationship between coronary artery disease and postprandial triglyceride levels显示文摘 | Atar IA Atar I Aydinalp A | 2011 | Anadolu Kardiyol Derg2011，11，3： | 1 |
| 17 | Home versus ambulatory and office blood pressure in predicting target organ damage in hypertension:a systematic review and meta-analysis显示文摘 | Bliziotis IA Destounis A Stergiou GS | | 0，，07： | 1 |
| 18 | A novel subclass of thalidomide analogue with anti-solid tumor activity in which caspase-dependent apaptesis is associated with altered expression of bcl-2 family proteins显示文摘 | Marriott JB Clarke IA Czajka A | 2003 | Cancer Res2003，63，2： | 1 |
| 19 | Hepatic artery thrombosis after liver transplantation: temporal accuracy of diagnosis with duplex US and the syndrome of impending thrombosis 显示文摘 | Nolten A Sproat IA | 1996 | Radiology1996，198，2： | 1 |
| 20 | Association of urinary bis- phenol A concentration with medical disorders and laboratory abnor- malities in adults显示文摘 | Lang IA Galloway TS Scarlett A | 2008 | JAMA2008，300，： | 1 |
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