|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ocular drug delivery systems:An overview显示文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed. | Ashaben Patel Kishore Cholkar Vibhuti Agrahari Ashim K Mitra | 2013 | World Journal of Pharmacology2013，2，2： | 18 |
| 2 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 3 | Molecular evidence and functional expression ofmultidrug resistanceassoeiated protein (MRP) in rabbit corneal epithelial cells显示文摘 | Pradeep K K Dananjay P Ashim K M | 2007 | Exp Eye Res2007，84，1： | 1 |
| 4 | Effect of hydroxypropyl beta cyclodextrin complexation on aqueous solubility, stability, and corneal permeation of acyl ester prodrugs of gancicl ovir显示文摘 | Giridhar S Tirucherai Ashim K | 2003 | AAPS Pharm Sci Tech2003，4，3： | 1 |
| 5 | Energy efficient zone division multihop hierarchical clustering algorithm for load balancing in wireless sensor network显示文摘 | ASHIM K G ANUPAM K B DR M A K | 2011 | International Journal of Advanced Computer Science and Application2011，2，12： | 1 |
| 6 | C or relat ion between n eur om aging and out come in perivenpricu lar leukomalacia: diagn os tic crit eria显示文摘 | H ashim ot o K H asegaw a H Kida Y e t al | 2001 | Pediat r Int2001，43，3： | 1 |
| 7 | Alcoholic turmeric extract simultaneously activating murine lymphocytes and inducing apoptosis of Ehlrich ascitic carcinoma cells显示文摘 | ASHIM K C HADIDA Y | 2005 | International Immunopharmacology2005，5，10： | 1 |
| 8 | Stability and bifurcation of a prey-predator model with time delay显示文摘 | KAR T K ASHIM B | 2009 | C R Biologies2009，332，： | 1 |
| 9 | Regional landscape change as a consequence of plantation forestry expansion:an example in the Nelson region,New Zealand显示文摘 | Nag ashim a K Sands R W hyte A G D | 2002 | Forest Ecology and Management2002，163，： | 1 |
| 10 | Error Estimates for approximate kinetic parameters used in food literature显示文摘 | Ashim K Datta | 1993 | Journal of Food Engineering1993，18，： | 1 |
| 11 | Acidity and activity of fluorinated mordenites 显示文摘 | Ashim K Ghosh Ronald A Kydd | 1987 | Journal of Catalysis1987，103，2： | 1 |
| 12 | Stability analysis and optimal control of an SIR epidemic model with vaccination 显示文摘 | Kar T K Ashim Batabyal | 2011 | BioSys- tems2011，104，： | 1 |
| 13 | Microbial degradation of soil fungns fusarium solani 显示文摘 | Chakraborty S K Ashim C Anjan B | 1995 | J Agric Food Chem1995，43，11： | 1 |
| 14 | Quality and safety driven optimal operation of deep-fat frying of potato chip显示文摘 | Ana Arias-Mendez Alexander Warning Ashim K Datta | 2013 | Journal of Food Engineering2013，119，1： | 1 |
| 15 | Stability and bifurcation of a prey-predator model with time delay显示文摘 | Kar T K Batabyal Ashim | 2009 | C R Biologies2009，，332： | 1 |
| 16 | Ocular pharmacokinetics of cephalosporins using microdialysis显示文摘 | SREERAJ M ASHIM K | 2001 | J Ocul Pharmocol Ther2001，17，5： | 1 |
| 17 | Transport and related properties of breads baked using various heating modes显示文摘 | Gulum Sumnu Ashim K Datta Serpil Sahin S | 2006 | Journal of Food Engineering2006，28，： | 1 |
| 18 | Saw dust and neem bark as low cost natural biosorbent for adsorptive removal of Zn(Ⅱ) and Cd(Ⅱ) ions from aqueous solutions 显示文摘 | Tarun K N Pankaj C Ashim K B | 2009 | Chemical En- gineering Journal2009，148，1： | 1 |
| 19 | Fibre Bragg gratings in structural health monitoring-present status and applications 显示文摘 | Mousumi M Tarun K G Ashim K C l | 2008 | Sensors and Actuators A2008，，147： | 1 |
| 20 | Effects of phospho1ipid chain length concertration, charge,and vesicle size onpulmonary insulin absorption显示文摘 | Yuping L Ashim K M | 1996 | Pharm Res1996，16，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员