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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | 欧洲儿童急性胃肠炎处理循证指南(2014年版)显示文摘1991年世界卫生组织(WHO)制订了第一版儿童急性腹泻病指南,2005年WHO和联合国儿童基金会(UNICEF)制订了第二版,我国专家在参照WHO指南的基础上,结合我国国情分别于1993年、2009年制订了中国儿童急性腹泻病的专家共识;WH0指南和我国共识对中国儿童急性腹泻病的规范诊治发挥了重要的作用,收到了良好的效果。时至今日,欧洲儿科胃肠病学、肝病学和营养协会及欧洲儿科感染病协会对2008年儿童急性胃肠炎循证指南进行更新,即“2014年版”。指南中腹泻病原、低渗口服补液盐溶液使用、营养管理和常规对症治疗与我国现行共识基本一致。另首次对儿童脱水评估和疾病严重程度评分进行量化并提出通过鼻胃管补液,这是我们可以借鉴的。重度脱水休克的治疗强调了可重复3次20ml/kg0.9%氯化钠溶液,与我国危重专业观点相一致。静脉补充液体成分与我国现行共识存在差异,与指南执笔者之一意大利学者AndreaLoVecehio进行交流,其认同我国现用液体组成。细菌感染所致腹泻使用抗生素的指征与我国现行共识相同,但在抗生素选择上存在差异,建议根据我国药典和药敏结果选择合适抗生素。由于我国社会经济、文化和医学发展等与欧洲存在差异,因此指南中的观点、方法等应结合中国特点进行应用。 | Alfredo Guarino Shai Ashkenazi Dominique Gendrel Andrea Lo Vecchio Raanan Shamir Hania Szajewska 方铁夫 耿岚岚 龚四堂 | 2015 | 中华儿科杂志2015，53，7： | 30 |
| 3 | Minimizing treatment complexity of combat-related soft tissue injuries using a dedicated tension relief system and negative pressure therapy augmented by high-dose in situ antibiotic therapy and oxygen delivery: a retrospective study显示文摘Background:Following combat-related,extensive soft tissue injury from gunshot wounds or blasts,prolonged duration from injury to full wound closure is associated with infection,increased morbidity and mortality,failure to mobilize,poor functional outcome and increased cost.The purpose of this study was to evaluate a novel treatment enabling early primary closure of combat wounds.Methods:This was a retrospective study of 10 soldiers and civilians with extensive combat-related soft tissue limb injuries(5 gunshot wounds,5 blasts)treated using the TopClosure^(■)Tension Relief System(TRS)with simultaneous administration of regulated oxygen-enriched and irrigation negative pressure-assisted wound therapy(ROINPT)via the Vcareα^(■)device.Results:Nine patients were treated during the acute phase of injury and one was treated following removal of a flap due to deep infection 20 years after injury and flap reconstruction.Two patients had upper limb injury and the rest lower limb injury.With the aid of the TRS and/or ROINPT,immediate primary closure during reconstruction was achieved in 6 patients and delayed primary closure in three.Only one patient required a skin graft to close a small area of the wound after most of the wound had been closed by delayed primary closure.Wound closure was achieved within 0–37 days(median:12.5 days,interquartile range:2.75–19.75)from injury.Conclusions:The TRS is a novel device for effective,early skin stretching and secure wound closure through the application of stress relaxation and mechanical creep,achieving primary closure of large defects using a simplified surgical technique and reducing the need for closure using skin grafts and flaps and the use of tissue expanders.Delivering supplemental oxygen to the wound by ROINPT reverses the reduced oxygen levels inherent in conventional negative pressure-assisted wound therapy,mitigating anaerobic contamination and reducing infection.Irrigation may accelerate the evacuation of infectious material from the wound and provide a novel method for antibiotic administration.The combination of TRS and ROINPT devices allow for early primary closure with improved functionality of combat-related limb injuries. | Moris Topaz Itamar Ashkenazi Oren Barzel Seema Biswas Dan Atar Nurit Shadmi Itzhak Siev-Ner | 2021 | Burns & Trauma2021，9，1： | 7 |
| 4 | Death receptors:signaling and modulation显示文摘 | Ashkenazi A Dixit VM | | 0，，： | 3 |
| 5 | Tumor necrosis factor: an apoptosis JuNKie显示文摘 | Varfolomeev E E Ashkenazi A | 2004 | Cell2004，116，4： | 1 |
| 6 | Death receptor signal transducers : nodes of coordination in immune signaling net-works 显示文摘 | Wilson NS Dixit V Ashkenazi A | 2009 | Nat Immunol2009，10，： | 1 |
| 7 | Resumption ofoocyte meiosis in mammals:on models,meiosis activa-ting sterols,steroids and EGF-like factors显示文摘 | Tsafriri A Cao X Ashkenazi H | 2005 | MolCell Endocrinol2005，234，： | 1 |
| 8 | Morphology and clinical outcomes of embryos after in vitro fertilization are superior to those after intracytoplasmic sperm injection显示文摘 | Hava IB Ashkenazi J Shelef M | 1997 | Fertil Steril1997，10，4： | 1 |
| 9 | Apo2L/TRAIL and its death and decoy recptors显示文摘 | LeBlanc HN Ashkenazi A | 2003 | Cell Death Differ2003，10，： | 1 |
| 10 | Eradication of propionibactcrium acnes by its endogenie poq hyrins after illumination with high intensity- blue light显示文摘 | Ashkenazi H Malik Z Harth Y | 2003 | FFMSI Mmunol Med Microbio12003，35，3： | 1 |
| 11 | 'Zionism and Violence in Albert Einstein's Political Outlook' 显示文摘 | Ashkenazi O | 2012 | Journal of Jewish Studies2012，63，2： | 1 |
| 12 | Death receptors: signaling and modulation 显示文摘 | Ashkenazi A Dixit VM | 1998 | Science1998，281，6： | 1 |
| 13 | Apoptosis control by death and decoy receptor显示文摘 | VISHVA M Dixit | 1999 | Current Opinion in Cell Biology1999，，11： | 1 |
| 14 | Effect of educational intervention on antibiotic prescription practices for upper respiratory infections in children:a multi- centre study 显示文摘 | Razon Y Ashkenazi S Cohen A | 2005 | J Antimicrob Chemother2005，56，5： | 1 |
| 15 | Hypertrophic spinal pachymeningitis:report of two cases and review of the literature显示文摘 | Ashkenazi E Constantini S Pappo O | 1991 | Neurosurgery1991，28，5： | 1 |
| 16 | Safety and antitumor activity of recombinant soluble Apo2 ligand 显示文摘 | Ashkenazi A Pal RC Fong S | 1999 | J Ciin Invest1999，104，： | 1 |
| 17 | Development of mircosatellite markers in potato and their use in phylogenetic and fingerprinting analyses显示文摘 | ASHKENAZI V CHANI E LAVI U | 2001 | Genome2001，44，： | 1 |
| 18 | Death receptors:signaling and modulation 显示文摘 | Ashkenazi A Dixit VM | 1998 | Science1998，281，5381： | 1 |
| 19 | Ligand-based targeting of apoptosis in cancer:the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)显示文摘 | Ashkenazi A Holland P Eckhardt SG | | 0，，： | 1 |
| 20 | New insights into apoptosis signaling byApo2L/TRAIL显示文摘 | Gonzalvez F Ashkenazi A | 2010 | Oncogene2010，29，34： | 1 |
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