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| 1 | Effects of tachyplesin on the morphology and ultrastructure of human gastric carcinoma cell line BGC-823显示文摘AIM To investigate the morphological andultrastructural changes in the human gastriccarcinoma cell line BGC-823 after being treatedwith tachyplesin.METHODS Tachyplesin was isolated from acidextracts of Chinese horseshoe crab(Tachypleustridentatus)hemocytes.BGC-823 cells and thecells treated with 2.0mg/L tachyplesin wereexamined respectively under light microscope,scanning and transmission electron microscope.RESULTS BGC-823 cells had undergone therestorational alteration in morphology andultrastructure after tachyplesin treatment.Thechanges were as follows:the shape of cells wasunanimous,the volume enlarged and cellsturned to be flat and spread,the nucleo-cytoplasmic ratio lessened and nuclear shapebecame rather regular,the number of nucleolusreduced and its volume lessened,heter-chromatin decreased while euchromatinincreased in nucleus.In the cytoplasm,mitochondria grew in number with consistentstructure relatively,Golgi complex turned to betypical and well-developed,rough endoplasmicreticulum increased and polyribosomedecreased.The microvilli at cellular surfacewere rare and the filopodia reduced whilelamellipodia increased at the cell edge.CONCLUSION Tachyplesin could alter themalignant morphological and ultrastructuralcharacteristics of human gastric carcinoma cellseffectively and have a certain inducing differen-tiation effect on human gastric carcinoma cells. | Li QF Ou Yang GL Li CY Hong SG | 2000 | World Journal of Gastroenterology2000，6，5： | 19 |
| 2 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 3 | Expression of perforin and granzyme B mRNA in judgement of immunosuppressive effect in rat liver transplantation显示文摘AIM To explore the expression of perform andgranzyme B genes mRNA to judge the effect ofimmunosuppression in acute rejection of livertransplantation.METHODS The expression of perform andgranzyme B genes mRNA was examined byreverse transcriptase-polymerase chain reaction(RT--PCR) in hamster to rat liver grafts under theimmunosuppression of cyclosporine or/andsplenectomy. Histological findings were studiedcomparatively.RESULTS Cyclosporine could obviouslydecrease the cellular infiltration, and completelyrepress the expression of mRNA for perform andgranzyme B, but could not change severehepatocyte necrosis and hemorrhage.SPlenectomy could significantly lightenhepatocyte necrosis, and completely eliminatehemorrhage, but not atfect the cellularinfiltration and the expression of perform andgranzyme B genes mRNA. Cyclosporine orsplenectomy alone could not prolong theSurvival time, however, their combination couldcompletely repress the rejection of liver grafts.The survival time of animals were significantlyprolonged (37.1 days ). The architecture ofhepatic lobules was preserved. There was slightcellular infiltration in the portal tracts and noexpression of perform and granzyme B genesmRNA could be seen in three weeks aftertransplantation.CONCLUSION Perform and granzyme B genesare valuable in judging the effect ofimmunosuppression in liver transplantation. | Zhang SG Wu MC Tan JW Chen H Yang JM Qian QJ | 1999 | World Journal of Gastroenterology1999，5，3： | 15 |
| 4 | N-甲基-D-天门冬氨酸-R1不同mRNA构型在斜视性弱视猫视皮层的表达显示文摘目的 了解在视觉发育可塑期 ,NMDA- R1受体基因的 m RNA构型与斜视性弱视猫视皮层神经元细胞水平表达减少有关的。 方法 同胞正常猫和斜视性弱视猫各两对 (共 4只 )。采用一系列地高辛核酸分子探针做猫脑片原位杂交 ,检测 NMDA- R1不同 m RNA构型在视皮层的表达情况。 结果 与正常猫相比 ,NMDA- R1m RNA“Pan”探针和 R1- a,R1- b,R1- 1构型探针在斜视性弱视猫视皮层的表达显著减少 ,主要在第 层。 R1- 3构型的表达在斜视性弱视猫视皮层比正常猫增加 ,主要在第 - 层。 R1- 2和 R1- 4构型的表达在正常猫和斜视猫视皮层的差异不显著。 结论 斜视性弱视猫视皮层 NMDA- R1m RNA特异构型的转录抑制导致受体蛋白水平表达的改变。 | 阴正勤 邓泽明 陈莉 Grewther SG | 2000 | 中华眼底病杂志2000，16，2： | 13 |
| 5 | Intraductalpapillarymucinousneoplasmofthebileductwithgastricand duodenalfistulas显示文摘Intraductal papillary mucinous neoplasm (IPMN) of the bile duct is still rare and not yet understood despite of its increased incidence and similar clinicopathologic characteristics compared with IPMN of the pancreas. The fistula formation into other organs can occur in IPMN, especially the pancreatic type. To our knowl-edge, only two cases of IPMN of the bile duct with a choledochoduodenal fistula were reported and we have recently experienced a case of IPMN of the bile duct penetrating into two neighboring organs of the stom-ach and duodenum presenting with abdominal pain and jaundice. Endoscopy showed thick mucin extruding from two openings of the fistulas. Endoscopic suction of thick mucin using direct peroral cholangioscopy with ultra-slim endoscope through choledochoduodenal fis-tula was very difficult and ineffective because of very thick mucin and next endoscopic suction through the stent after prior insertion of biliary metal stent into cho-ledochogastric fistula also failed. Pathologic specimen obtained from the proximal portion of the choledocho-gastric fistula near left intrahepatic bile duct through the metal stent showed a low grade adenoma. The pa-tient declined the surgical treatment due to her old age and her abdominal pain with jaundice was improved af-ter percutaneous transhepatic biliary drainage with the irrigation of N-acetylcysteine three times daily for 10 d. | Hong MY Yu DW Hong SG | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，7： | 7 |
| 6 | 如何处理疑似IgA过敏性输血反应显示文摘 | Sandler SG 洪小珍 | 2006 | 国际输血及血液学杂志2006，29，3： | 7 |
| 7 | Chimeric dopamine-norepinephrine transporters delineste structural domains influencing selectivity for catecholamine and 1-methyl-4-phenylpyridinium 显示文摘 | Buck KJ Amara SG | 1994 | Proc Natl Acad Sci USA1994，91，12： | 6 |
| 8 | 朊蛋白病诊断标志分子14-3-3Zeta基因亚克隆及其表达显示文摘目的 为了制备朊蛋白病特异性实验诊断的标志物及为探讨 14- 3 - 3在神经细胞功能调节中的作用创造条件。方法 根据 14- 3- 3Zeta亚型基因序列设计引物 ,扩增DNA片段 ,经酶切纯化后连接到pCYB3表达载体 ,转化大肠杆菌BL2 1菌株 ,用培养基筛选 ,经管状凝胶电泳纯化融合蛋白。结果与结论 获取了 14- 3- 3/pCYB3阳性重组体 ,经IPTG诱导及免疫印迹 -增强化学发光 (Westernblot-ECL)鉴定 ,表达出 14- 3- 3/intein -CBD融合蛋白 ,分子量为 82 7kDa . | 沈继龙 SG CHEN | 2000 | 中国人兽共患病杂志2000，16，5： | 4 |
| 9 | Human immunodeficiency virus-related primary central nervous system lymphoma: factors influencing survival in 111 patients显示文摘BACKGROUND: The current study evaluated factors influencing survival in patients diagnosed with human immunodeficiency virus (HIV)-related primary central nervous system lymphoma (PCNSL), with a focus on the effects of therapeutic radiotherapy (RT) and highly active antiretroviral therapy (HAART). METHODS: A retrospective chart review of patients with a diagnosis of HIV-related PCNSL at one of five university hospitals between 1987 and 1998 was performed. Clinical details including antiretroviral agent use, brain imaging scan results, RT use, and survival outcomes were recorded. RESULTS: One hundred eleven patients with HIV-related PCNSL were identified. The annual incidence decreased significantly between 1992 and 1995 and between 1996 and 1998 (P=0.04). | Newell ME Hoy JF Cooper SG DeGraaff B Grulich AE Bryant M Millar JL Brew BJ Quinn DI | 2004 | 中国神经肿瘤杂志2004，2，2： | 4 |
| 10 | 经颅直流电刺激对痛觉过敏的逆转显示文摘神经性疼痛的出现来自周围和中枢神经损伤,并且包含明显的临床症状和经常使人呈现衰弱的状态。以往的研究表明,经颅直流电刺激(tDCS)在其他疼痛试验模型中能够影响疼痛的传输,此研究旨在探究 tDCS 在神经性疼痛(NP)模型中对疼痛和细胞因子影响。 | 陆晶晶 顾旭东 Cioato SG Medeiros LF Marques Filho PR | 2016 | 中国康复2016，31，5： | 4 |
| 11 | 脊髓背角内参与机械性痛觉超敏的神经环路由损伤性质决定显示文摘脊髓背角是诱发和维持机械性痛觉超敏反应的主要部位,但参与该痛觉信号传递的神经环路至今仍不清楚。本研究发现,脊髓背角参与机械性痛觉超敏的神经环路因损伤性质而异。脊髓背角Ⅱ层的钙结合蛋白(CR)神经元传递由炎性损伤诱导的机械性痛觉超敏反应,而Ⅱ/Ⅲ层边缘的蛋白激酶Cγ(PKCγ)神经元传递由神经损伤诱导的机械性痛觉超敏反应。胆囊收缩素(CCK)神经元位于脊髓背角深层(Ⅲ-Ⅳ层),对上述两种类型损伤诱导的机械性痛觉超敏均至关重要。有趣的是,Maf阳性的CCK神经元由瞬时囊泡谷氨酸转运体3 (tVGLUT3)神经元组成,主要传递动态痛觉超敏反应。基于病因研究脊髓背角传递机械性痛觉超敏信号的神经环路具有重要的理论与临床意义。 | 郁梅(译) 唐宗湘(校) Peirs C Williams SG Zhao X | 2021 | 中国疼痛医学杂志2021，27，6： | 4 |
| 12 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 13 | 失眠在创伤后应激障碍与高血压关系中的作用显示文摘创伤后应激障碍(posttraumatic stress disorder,PTSD)与高血压发病相关。PTSD还与失眠症相关,尽管对两者关系知之甚少,但它会增加高血压患病风险。失眠是否会增加PTSD相关的高血压风险目前仍是未知的。方法:研究者检索了1109名女性退伍军人队列研究(women veterans cohort study)参与者[平均年龄为(43.8±10.9)岁;52%为女性,81%为白人]的问卷调查和电子健康记录数据,评估其PTSD症状严重程度、近期失眠症状与高血压的横断面关系。 | 周卫(译) 袁源(审校) Gaffey AE Redeker NS Rosman L Mullington MJ Brandt CA Haskell SG Burg MM | 2020 | 中华高血压杂志2020，28，9： | 3 |
| 14 | 低浓度胰岛素样生长因子Ⅱ可以预报正常体重2型糖尿病患者的体重增加显示文摘 | Heald AH Karvestedt L Anderson SG 菅鑫妍 | 2006 | 中国处方药2006，5，6： | 3 |
| 15 | 老年及老年前期的听性脑干反应显示文摘 | 郭养淳 Harn.,SG | 1990 | 中华耳鼻咽喉科杂志1990，25，1： | 3 |
| 16 | Singularity Detection and Processing with Wavelets显示文摘 | Mallat SG Hwang WL | | 0，，： | 3 |
| 17 | 曲安奈德辅助玻璃体切割术的应用显示文摘目的研究曲安奈德(TA)辅助玻璃体切割手术在临床的应用价值.方法28例(29只眼)于2004年1月~2004年12月行玻璃体切割术,术中注入已过滤的TA悬浮液0.1ml (40mg/ml),以帮助辨认玻璃体后皮质、视网膜前增殖膜、黄斑前膜、内界膜,9例硅油填充,7例C3F8(15%)填充.手术后17例随访6个月以上,11例随访3至4个月.结果所有的病例,经TA注入后,可明显的改善玻璃体后皮质、视网膜前膜、内界膜的辨认情况.糖尿病视网膜病变术后视力提高占61.5%,伴PVR的视网膜脱离术后视力提高占61.3%,黄斑裂孔4例中3例术后视力提高,4例黄斑前膜术后视力均有提高.所有28例均没有出现高眼压.8例伴PVR的视网膜脱离中6例(占75%)视网膜复位,4例黄斑裂孔均关闭,2例糖尿病黄斑水肿手术后明显减轻.结论经过滤的TA可作为玻璃体切割手术中较好的辅助工具,TA悬浮液是呈白色胶样,可粘附于玻璃体皮质、视网膜前膜或内界膜,帮助分辨玻璃体后皮质、视网膜前膜、内界膜,提高手术效率.没有发现与TA有关的副作用. | 何建忠 许春丽 Ong SG | 2005 | 中国实用眼科杂志2005，23，11： | 3 |
| 18 | Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocyte-derived dendritic cells显示文摘 | Zhang,W Ge,W Li,CH You,SG Liao,LM Han,Q Deng,WM Zhao,RCH | 2005 | 中国生物学文摘2005，19，3： | 3 |
| 19 | Comparative screening for thyroid disorders in old age in areas of iodine deficiency, long‐term iodine prophylaxis and abundant iodine intake显示文摘 | IstvánSzabolcs JanPodoba JoachimFeldkamp OrsolyaDohán IldikóFarkas MihálynéSajgó Krisztina I.Takáts MiklósGóth LászlóKovács KatalinKressinszky PeterHnilica GézaSzilágyi | 2003 | Clinical Endocrinology2003，，1： | 2 |
| 20 | Production of C - reactive protein and risk of coronary events in stable and unstable angina: european concerted action on thrombosis and disabilities angina pectoris study group显示文摘 | Haverkate F Thompson SG Pyke SD | 1997 | Lancet1997，349，9050： | 2 |
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