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| 1 | Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation显示文摘AIM: To identify signaling pathways and genes that initiate and commit hepatic stellate cells (HSCs) to transdifferentiation. METHODS: Primary HSCs were isolated from male Sprague-Dawley rats and cultured on plastic for 0-10 d. Gene expression was assessed daily (quiescent to day 10 culture-activation) by real time polymerase chain reaction and data clustered using AMADA software. The significance of JAK/STAT signaling to HSC transdifferentiation was determined by treating cells with a JAK2 inhibitor. RESULTS: Genetic cluster analyses, based on expression of these 21 genes, showed similar expression profiles on days 1-3, days 5 and 6, and days 7-10, while freshly isolated cells (day Q) and day 4 cells were genotypically distinct from any of the other days. Additionally, gene expression clustering revealed strong upregulation of interleukin-6, JAK2 and STAT3 mRNA in the early stages of activation. Inhibition of the JAK/STAT signaling pathway impeded the morphological transdifferentiation of HSCs which correlated with decreased mRNA expression of several profibrotic genes including collagens, α-SMA, PDGFR and TGFβR. CONCLUSION: These data demonstrate unique clustered genetic profiles during the daily progression of HSC transdifferentiation and that JAK/STAT signaling may be critical in the early stages of transdifferentiation. | Ashley M Lakner Cathy C Moore Alyssa A Gulledge Laura W Schrum | 2010 | World Journal of Gastroenterology2010，16，40： | 23 |
| 2 | 2009年南极冰穹A的双色天光背景统计和分析显示文摘天光背景是天文台址的一个重要指标。利用2009年位于南极冰穹A的CSTAR望远镜两个波段的观测数据,对南极冰穹A的天光背景进行了统计和分析。结果表明约74%的g波段天光背景的ADU值小于每像素100/s;90.5%的r波段的天光背景的ADU值小于每像素100/s。在不考虑大气消光的情况下,定标后的结果为2009年冰穹A的观测数据中天光背景亮度的中值:g波段为19.9 mag/arcsec2,r波段为20.1 mag/arcsec2。 | 宗伟凯 付建宁 牛家树 Ashley Michael C B 宫雪非 Lawrence J S 刘强 Luong-Van Daniel Pennypacker C R Storey John W V 王灵芝 王力帆 杨惠根 袁祥岩 York Donald G 朱镇熹 | 2014 | 天文研究与技术2014，11，1： | 2 |
| 3 | IL-17-producing human peripheral regulatory T cells retain suppressive function显示文摘 | Beriou G Costantino C M Ashley C W | 2009 | Blood2009，113，18： | 1 |
| 4 | Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation显示文摘 | AJ Stanley D Ashley HR Dalton C Mowat DR Gaya E Thompson U Warshow M Groome A Cahill G Benson O Blatchford W Murray | 2009 | The Lancet2009，，9657： | 1 |
| 5 | A review of the opti- cal properties of biological tissues 显示文摘 | WAIF C SCOTT A P ASHLEY J W | 1990 | IEEE J Quant Elee1990，26，12： | 1 |
| 6 | Determination of Nicotine and Other Minor Alkaloids in International Cigarettes by Solid-Phase Microextraction and Gas Chromatography/Mass Spectrometry显示文摘 | Wu W Ashley D L Watson C H | 2002 | Analytical Chemistry2002，74，19： | 1 |
| 7 | Planning for multipurpose greenways in Concord,North Carolina显示文摘 | Xiang W N Young J | 2004 | Landscape and Urban Planning2004，68，： | 1 |
| 8 | Regional variations in small intestinal submucosa evoke differences in inflammation with subsequent impact on tissue regeneration in the rat bladder augmentation model显示文摘 | Ashley R A Roth C C Palmer B W | 2010 | BJU Int2010，105，10： | 1 |
| 9 | Satellite cell activation on fibers: modeling events in vivo-an invited review显示文摘 | JUDY E A ASHLEY C W | 2004 | Can J Physiol Pharmacol2004，82，： | 1 |
| 10 | 2-Phenylindole显示文摘 | Shriner R L Ashley W C Welch E | 1955 | Organic Syntheses1955，3，： | 1 |
| 11 | Arbuscular mycorrhizas in southeastern Australian processing tomato farm soils显示文摘 | Timothy R C Ashley W M | 2011 | Plant Soil2011，340，： | 1 |
| 12 | Advertising and aggregate consumption: An analysis of causality显示文摘 | Ashley R Granger C W J Schmalensee R | 1980 | Econometrica1980，48，5： | 1 |
| 13 | Targeted disruption of the α1,3-galactosytransferase gene in cloned pigs显示文摘 | Todd D V Jeremy B Shu-Hung Chen Carol J P Suyapa B Jeff A M Peter M J Kenneth J M Ashley E Lamborn Jamie L Cowell-Lucero Kevin D W Alan C Irina A P David L A | 2002 | Nat Biotechnology2002，20，3： | 1 |
| 14 | IL-17produ-cing human peripheral regulatory T cells retain suppressive function显示文摘 | Beriou G Costantino C M Ashley C W | 2009 | Blood2009，113，18： | 1 |
| 15 | Nutrient supply and the growth of the seminal root system in barley 显示文摘 | DREW M C SAKER L R ASHLEY T W | 1973 | Journal of Experimental Botany1973，24，： | 1 |
| 16 | Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations显示文摘 | Reeves C D Murli S Ashley G W | 2001 | Biochemistry2001，40，15： | 1 |
| 17 | Small intestine gastro-intestinal stromal tumors 显示文摘 | Grover S Ashley S W Raut C P | 2012 | Curr Opin Gastroenterol2012，28，2： | 1 |
| 18 | Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry显示文摘 | WU W ASHLEY D L WATSON C H | 2003 | Analytical Chemistry2003，75，18： | 1 |
| 19 | Small intestine gastrointestinal stromal tumors显示文摘 | Grover S Ashley S W Raut C P | 2012 | Curr Opin Gastroenterol2012，28，2： | 1 |
| 20 | Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry显示文摘 | Wu W Ashley D L Watson C H | 2003 | Anal Chem2003，75，18： | 1 |
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